Pediatric Infection and Vaccine

The Korean Society of Pediatric Infectious Diseases (대한소아감염학회)
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Comparison of Group A, B and C Rotaviral Gastroenteritis among Children in Korea: Prevalence and Clinical Features

한국 소아에서의 로타 장염군의 비교: 유병율과 임상증상

  • Bae, Kil-Seong (Department of Pediatrics, The Catholic University of Korea, Bucheon St Mary's Hospital) ;
  • Bae, Woo Ri (Department of Pediatrics, The Catholic University of Korea, Bucheon St Mary's Hospital) ;
  • Kim, Ji Hoon (Department of Pediatrics, The Catholic University of Korea, Bucheon St Mary's Hospital) ;
  • Bin, Joong Hyun (Department of Pediatrics, The Catholic University of Korea, Bucheon St Mary's Hospital) ;
  • Kim, Hyun Hee (Department of Pediatrics, The Catholic University of Korea, Bucheon St Mary's Hospital) ;
  • Lee, Hee Jin (Clinical Medical Research Institute, The Catholic University of Korea, Bucheon St Mary's Hospital) ;
  • Lee, Wonbae (Department of Pediatrics, The Catholic University of Korea, Bucheon St Mary's Hospital)
  • 배길성 (가톨릭대학교 의과대학 소아과학교실) ;
  • 배우리 (가톨릭대학교 의과대학 소아과학교실) ;
  • 김지훈 (가톨릭대학교 의과대학 소아과학교실) ;
  • 빈중현 (가톨릭대학교 의과대학 소아과학교실) ;
  • 김현희 (가톨릭대학교 의과대학 소아과학교실) ;
  • 이희진 ;
  • 이원배 (가톨릭대학교 의과대학 소아과학교실)
  • Received : 2013.08.15
  • Accepted : 2014.06.09
  • Published : 2014.08.25
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Abstract

Purpose: The aim of this study is that the prevalence of rotavirus infection was evaluated by each group and clinical features of group A, B and C rotaviruses infections were described respectively to compare one with another. Methods: Between January 2010 and December 2010, we enrolled a group of children below 10 years of age admitted for management of acute diarrhea at the Catholic University of Korea Bucheon St. Mary's Hospital. A total of 310 stool samples documented to be free of common bacterial pathogens were collected from children with diarrhea. The presence of group A, B or C rotavirus is indicated by amplification of DNA segments of the expected lengths after the first and second PCRs Results: In a total of 310 stool specimens, 40 (12.9%) specimens were positive for rotaviruses. These included 23 (7.4%) positive for group A, 5 (1.6%) for group B and 12 (3.9%) for group C rotaviruses. Group B rotavirus infected patients had significantly less diarrheas per day (group A: P =0.01, group C: P =0.01) and shorter duration of vomiting days (group A: P =0.03, group C: P =0.03) than those with group A and C rotaviruses infection respectively. All the group B rotaviruses had been isolated in March and October. Group C rotavirus infections were prevalent during late summer and early winter and peaked in October. Conclusion: These findings indicate that group B and C rotaviruses are notable causes or the contributing causes of diarrhea among infants and children in Korea.

목적: 본 연구의 목표는 로타 바이러스 감염의 유병률을 로타 바이러스 A, B, C 군으로 나누어 평가하고 각 군의 임상 양상을 서로 상대적으로 비교함에 있다. 방법: 2010년 1월에서 2010년 12월 사이에, 부천 성모병원에 급성 장염으로 입원한 10세 미만 환아를 대상으로, 총 310개의 대변표본이 추출되었고, PCR을 통해 DNA 증폭과정을 거쳐, A, B, C 군의 로타 바이러스 군을 구분하였다. 결과: 총 310개의 대변표본에서 40개(12.9%)에서 로타 바이러스 양성이 확인되었으며, 이중 23개(7.4%)가 로타 바이러스 A군에 양성, 5개(1.6%)가 B군, 12개(3.9%)가 C군에 양성 소견을 보였다. B군은 A군과 C군에 비교하여 유의하게 경한 설사증상과 짧은 구토기간을 보였다(group A: P =0.01, group C: P =0.01) 모든 B군 로타 바이러스는 3월과 10월에 발견되었으며, C군은 늦은 여름과 초겨울에, 그 중에서 10월에 최고의 유병률을 보였다. 결론: 국내에서 로타 바이러스 장염은 주로 로타 바이러스 A군에 의하여 발생하였다. 그러나 일부에서는 로타 바이러스 C군과 B군이 원인으로 확인된바 향후 이에 대한 지속적인 연구가 필요할 것으로 사료된다.

Keywords

References

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