Pediatric Infection and Vaccine

The Korean Society of Pediatric Infectious Diseases (대한소아감염학회)
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Neonatal Meningoencephalitis caused by Herpes Simplex Virus Type 2

Herpes simplex virus type 2에 의한 신생아 수막뇌염

  • Kim, Dae Eun (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Pae, Ramee (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Bae, E Young (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Han, Ji Yoon (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Han, Seung Beom (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Jeong, Dae Chul (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Lee, In Goo (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Kang, Jin Han (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
  • 김대은 (가톨릭대학교 의과대학 소아과학교실) ;
  • 배라미 (가톨릭대학교 의과대학 소아과학교실) ;
  • 배이영 (가톨릭대학교 의과대학 소아과학교실) ;
  • 한지윤 (가톨릭대학교 의과대학 소아과학교실) ;
  • 한승범 (가톨릭대학교 의과대학 소아과학교실) ;
  • 정대철 (가톨릭대학교 의과대학 소아과학교실) ;
  • 이인구 (가톨릭대학교 의과대학 소아과학교실) ;
  • 강진한 (가톨릭대학교 의과대학 소아과학교실)
  • Received : 2014.01.16
  • Accepted : 2014.04.08
  • Published : 2014.08.25
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Abstract

Despite its rare occurrence, early diagnosis and appropriate treatment for neonatal herpes simplex virus infection are mandatory due to its high morbidity and mortality. In Korea, there has been no epidemiologic data on neonatal herpes simplex virus infection, and even case reports are rare. We observed a 16-day-old neonate who presented with fever and seizures. We diagnosed her with meningoencephalitis caused by herpes simplex virus type 2 based on the polymerase chain reaction test, and treated her with intravenous acyclovir and anticonvulsants. The seroprevalence of herpes simplex virus type 2 sharply increases in women in their 30s, and the average age for childbirth has increased to older than 30 years of age in Korea; we therefore expect that the incidence of neonatal herpes simplex virus type 2 infection will rise in Korea, and more attention should be directed to neonatal herpes simplex virus type 2 infection. We report this newborn patient's case along with a literature review.

신생아 HSV 감염은 주로 HSV type 2에 의해 발생하는 것으로 알려져 있으나, 국내에서는 신생아 HSV 감염의 역학 자료뿐만 아니라, HSV type 2가 증명된 신생아 수막뇌염 증례 보고조차 없었다. 저자들은 열과 경련을 주소로 내원한 생후 16일 신생아에서 PCR 검사를 통해 HSV type 2에 의한 수막뇌염을 진단하고 acyclovir 및 항경련제 치료를 시행하였다. 환자는 뇌 MRI 검사에서 뇌연화증이 있어 성장과 발달에 대해 추적 관찰 중이다. 우리나라 여성에서 30대에 HSV type 2 초감염이 가장 빈번히 발생하고 최근 평균 초산 연령이 증가하여 30대로 진입함에 따라 향후 HSV type 2에 의한 신생아 감염이 증가될 것으로 예상되어, HSV type2 감염은 열이 나는 신생아에서 반드시 고려해야 할 것이다.

Keywords

References

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