The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
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Protective Effects of Complex Diet of Korean red ginseng and fish oil on UV-induced Photoaging

홍삼과 어유(魚油) 복합식이에 의한 UV-유도 광노화 억제효과

  • Mun, Yeun-Ja (BK21-plus Team, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Jeon, Byoung-Kook (BK21-plus Team, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kim, Tae-Hyun (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Jin-Ho (BK21-plus Team, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Choi, Hyung-Wook (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lim, Kyu-Sang (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Woo, Won-Hong (Department of Anatomy, College of Oriental Medicine, Wonkwang University)
  • 문연자 (원광대학교 한의학전문대학원 한약자원개발학과 BK21팀) ;
  • 전병국 (원광대학교 한의학전문대학원 한약자원개발학과 BK21팀) ;
  • 김태현 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 이진호 (원광대학교 한의학전문대학원 한약자원개발학과 BK21팀) ;
  • 최형욱 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 임규상 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 우원홍 (원광대학교 한의과대학 해부학교실)
  • Received : 2014.06.26
  • Accepted : 2014.08.14
  • Published : 2014.08.25
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Abstract

Objective : UV irradiatiion causes skin-aging involving coarse wrinkles, thickning, dyspigmentation, and rough skin surface. This study was aimed to elucidate the anti-winkle activity of complex diet of Korean red ginseng (RG) and fish oil (FO) on UV-induced Photoaging. Methods : To investigated photo-protective effects of Korean red ginseng and fish oil on UV-induced damaged skins, SKH hairless female mice were randomly divided into six groups [control, UV, UV/RG, UV/FO, UV/RG/FO(low), UV/RG/FO(high)]and orally administered three times a week respectively. UV radiation was applied to the backs of the mice three times a week for 8 weeks. Expressions of matrix metalloproteinase (MMP)-3, MMP-13 and tissue inhibitor matrix metalloproteinase (TIMP)-1 in skin were measured by immunohistochemical staining. Results : In this study, UVB-induced epidermal hypertropy was diminished by RG group or FO group or complex group of RG and FO. Expression levels of MMP-3 and MMP-13 were reduced and expression level of TIMP-1 was increased by RG group or FO group or complex group of RG and FO. Especially MMP-3 and MMP-13 were markedly reduced by diet of FO and complex diet of RG and FO compared with untreated group. Conclusions : This results suggest that complex diet of RG and FO have a anti-wrinkle activity on UV-induced photo-aging and intrinsic aging.

Keywords

References

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