Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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A Case of Lung Carcinoma with Rhabdoid Phenotype Mimicking an Aspergilloma in Patient with Recurrent Hemoptysis

  • Kim, Moo Woong (Division of Tuberculosis and Pulmonology, Department of Internal Medicine, Kwangju Christian Hospital) ;
  • Rew, Soo Jung (Division of Tuberculosis and Pulmonology, Department of Internal Medicine, Kwangju Christian Hospital) ;
  • Eun, Seo Joon (Division of Tuberculosis and Pulmonology, Department of Internal Medicine, Kwangju Christian Hospital) ;
  • Lee, Ui Sin (Division of Tuberculosis and Pulmonology, Department of Internal Medicine, Kwangju Christian Hospital) ;
  • Park, Chan Woo (Division of Tuberculosis and Pulmonology, Department of Internal Medicine, Kwangju Christian Hospital) ;
  • Jeong, Jong Pil (Division of Tuberculosis and Pulmonology, Department of Internal Medicine, Kwangju Christian Hospital) ;
  • Ko, Young Choon (Division of Tuberculosis and Pulmonology, Department of Internal Medicine, Kwangju Christian Hospital)
  • Received : 2014.03.04
  • Accepted : 2014.04.28
  • Published : 2014.07.30
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Abstract

Malignant rhabdoid tumor was first discovered in the kidney, and rhabdoid tumor of the lung was first reported in 1995. These were included as the variants of large-cell carcinoma, according to the 1999 World Health Organization classification of lung tumors. The rhabdoid tumor of the lung exhibits aggressive biological behavior and has a poor prognosis, and only a few reports of this tumor exist. We report a case of lung carcinoma with a rhabdoid phenotype, initially misdiagnosed as an aspergilloma, in a 48-year-old man who presented with recurrent hemoptysis. The chest computed tomography scans showed a huge consolidative lesion with an air crescent sign in the left upper lung and no contrast-enhancing lesion. An aspergilloma was diagnosed by the radiologist. However, after surgical excision and pathological examination, rhabdoid carcinoma was diagnosed. A surgical resection helps to make it possible to pathologically distinguish a malignancy from an aspergilloma.

Keywords

References

  1. Beckwith JB, Palmer NF. Histopathology and prognosis of Wilms tumors: results from the First National Wilms' Tumor Study. Cancer 1978;41:1937-48. https://doi.org/10.1002/1097-0142(197805)41:5<1937::AID-CNCR2820410538>3.0.CO;2-U
  2. Colby TV, Koss MN, Travis WD. Tumors of the lower respiratory tract. Atlas of tumor pathology. Fascicle 13. Washington, DC: AFIP; 1995. p. 311.
  3. Travis WD, Colby TV, Corrin B, Shimosato Y, Brambilla E. Histological typing of the lung and pleural tumours. Berlin: Springer-Verlag; 1999. p. 40-2.
  4. Tamboli P, Toprani TH, Amin MB, Ro JS, Ordonez NG, Ayala AG, et al. Carcinoma of lung with rhabdoid features. Hum Pathol 2004;35:8-13. https://doi.org/10.1016/j.humpath.2003.07.019
  5. Parham DM, Weeks DA, Beckwith JB. The clinicopathologic spectrum of putative extrarenal rhabdoid tumors. An analysis of 42 cases studied with immunohistochemistry or electron microscopy. Am J Surg Pathol 1994;18:1010-29. https://doi.org/10.1097/00000478-199410000-00005
  6. Cavazza A, Colby TV, Tsokos M, Rush W, Travis WD. Lung tumors with a rhabdoid phenotype. Am J Clin Pathol 1996;105:182-8. https://doi.org/10.1093/ajcp/105.2.182
  7. Shimazaki H, Aida S, Sato M, Deguchi H, Ozeki Y, Tamai S. Lung carcinoma with rhabdoid cells: a clinicopathological study and survival analysis of 14 cases. Histopathology 2001;38:425-34. https://doi.org/10.1046/j.1365-2559.2001.01145.x
  8. Saini G, Kumar M, Julka PK, Puri T, Sharma M, Rath GK. Rhabdoid variant of lung cancer: clinicopathological details of a case and a review of literature. J Cancer Res Ther 2009;5:54-7. https://doi.org/10.4103/0973-1482.48773
  9. Travis WD, Brambilla E, Muller-Hermlink HK, Harris CC. World Health Organization classification of tumors: pathology and genetics of tumors of the lung, pleura, thymus and heart. Lyon: IARC Press; 2004. p. 45-50.
  10. Haas JE, Palmer NF, Weinberg AG, Beckwith JB. Ultrastructure of malignant rhabdoid tumor of the kidney. A distinctive renal tumor of children. Hum Pathol 1981;12:646-57. https://doi.org/10.1016/S0046-8177(81)80050-0
  11. Park Y, Kim TS, Yi CA, Cho EY, Kim H, Choi YS. Pulmonary cavitary mass containing a mural nodule: differential diagnosis between intracavitary aspergilloma and cavitating lung cancer on contrast-enhanced computed tomography. Clin Radiol 2007;62:227-32. https://doi.org/10.1016/j.crad.2006.11.001
  12. Wu CY, Hu HY, Pu CY, Huang N, Shen HC, Li CP, et al. Pulmonary tuberculosis increases the risk of lung cancer: a population- based cohort study. Cancer 2011;117:618-24. https://doi.org/10.1002/cncr.25616
  13. Hiroshima K, Shibuya K, Shimamura F, Toyozaki T, Haga Y, Ohwada H, et al. Pulmonary large cell carcinoma with rhabdoid phenotype. Ultrastruct Pathol 2003;27:55-9. https://doi.org/10.1080/01913120309949