Korean Journal of Fisheries and Aquatic Sciences (한국수산과학회지)

The Korean Society of Fisheries and Aquatic Science (한국수산과학회)
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The Effects of Anti-Obesity on Enzyme-treated Ecklonia cava Extracts

효소 처리한 감태(Ecklonia cava) 분획물의 항비만 효과

  • Kim, Seul-Young (Department of Food Science and Nutrition, Pukyong National University) ;
  • Yun, In-Jue (Ju Yeong NS Co., Ltd.) ;
  • Kwon, Chang-Ju (Ju Yeong NS Co., Ltd.) ;
  • Choi, Jung-Wook (Department of Food Science and Nutrition, Pukyong National University) ;
  • Kim, Young-Min (Department of Food Science and Nutrition, Pukyong National University) ;
  • Kang, Mi-Hye (Department of Food Science and Nutrition, Pukyong National University) ;
  • Lee, Min-Kyeong (Department of Food Science and Nutrition, Pukyong National University) ;
  • Nam, Taek-Jeong (Department of Food Science and Nutrition, Pukyong National University)
  • Received : 2014.07.25
  • Accepted : 2014.08.05
  • Published : 2014.08.31
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Abstract

Obesity is a worldwide problem that contributes to serious diseases, including diabetes, hypertension, and atherosclerosis. Recently, much research has examined functional natural materials and their anti-obesity activity. This study investigated the effect of enzyme-treated Ecklonia cava extracts on mice fed a high fat diet. To test the anti-obesity effects of a diet containing the enzyme-treated E. cava extracts (EEc), C57BL/6NTacSam mice were divided into six groups : normal diet (ND), high-fat diet (HFD), high-fat with Garcinia extract diet (GHD), and three high-fat with EEc diet (EHD250, EHD500, and EHD1000) groups. After 9 weeks, body weight was increased significantly in the HFD group compared to all of the EHD groups, and the weights of the liver, perirenal fat and epididymal fat paralleled the increase in body weight. The serum GOT, GPT, triglyceride, total cholesterol, and LDL-cholesterol levels were lower in the EHD1000 group than in the HFD group. The glucose and leptin concentrations were lowest in the EHD1000 group and C/EBP family expression was decreased in a dose-dependent manner. These results indicate that E. cava extracts not only have anti-oxidation functions but also anti-obesity effects.

Keywords

References

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