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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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TM4SF5-mediated protein-protein networks and tumorigenic roles

  • Lee, Jung Weon (Department of Pharmacy, Research Institute of Pharmaceutical Sciences, Tumor Microenvironment Global Core Research Center, Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University)
  • Received : 2014.07.11
  • Published : 2014.09.30
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Abstract

Transmembrane 4 L six family member 5 (TM4SF5), as a membrane glycoprotein with 4 transmembrane domains, is similar to the tetraspanins in terms of membrane topology and plays important roles in tumorigenesis and tumor metastasis. Especially, TM4SF5 appears to form a massive protein-protein complex consisting of diverse membrane proteins and/or receptors in addition to cytosolic signaling molecules to regulate their signaling activities during the pathological processes. TM4SF5 is shown to interact with integrins ${\alpha}2$, ${\alpha}5$, and ${\beta}1$, EGFR, IL6R, CD151, focal adhesion kinase (FAK), and c-Src. This review focuses on the significance of the interactions with regards to TM4SF5-positive tumorigenesis and metastasis.

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References

  1. Veenbergen, S. and van Spriel, A. B. (2011) Tetraspanins in the immune response against cancer. Immunol. Lett. 138, 129-136. https://doi.org/10.1016/j.imlet.2011.03.010
  2. Detchokul, S., Williams, E. D., Parker, M. W. and Frauman, A. G. (2013) Tetraspanins as regulators of the tumour microenvironment: implications for metastasis and therapeutic strategies. Br. J. Pharmacol. doi: 10.1111/bph.12260.
  3. Lee, S. A., Park, K. H. and Lee, J. W. (2011) Modulation of signaling between TM4SF5 and integrins in tumor microenvironment. Front. Biosci. 16, 1752-1758. https://doi.org/10.2741/3818
  4. Hemler, M. E. (2003) Tetraspanin proteins mediate cellular penetration, invasion, and fusion events and define a novel type of membrane microdomain. Annu. Rev. Cell Dev. Biol. 19, 397-422. https://doi.org/10.1146/annurev.cellbio.19.111301.153609
  5. Hemler, M. E. (2005) Tetraspanin functions and associated microdomains. Nat. Rev. Mol. Cell Biol. 6, 801-811. https://doi.org/10.1038/nrm1736
  6. Yanez-Mo, M., Barreiro, O., Gordon-Alonso, M., Sala-Valdes, M. and Sanchez-Madrid, F. (2009) Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes. Trends. Cell Biol. 19, 434-446. https://doi.org/10.1016/j.tcb.2009.06.004
  7. Lee, S. A., Lee, S. Y., Cho, I. H., Oh, M. A., Kang, E. S., Kim, Y. B., Seo, W. D., Choi, S., Nam, J. O., Tamamori-Adachi, M., Kitajima, S., Ye, S. K., Kim, S., Hwang, Y. J., Kim, I. S., Park, K. H. and Lee, J. W. (2008) Tetraspanin TM4SF5 mediates loss of contact inhibition through epithelial-mesenchymal transition in human hepatocarcinoma. J. Clin. Invest. 118, 1354-1366. https://doi.org/10.1172/JCI33768
  8. Muller-Pillasch, F., Wallrapp, C., Lacher, U., Friess, H., Buchler, M., Adler, G. and Gress, T. M. (1998) Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer. Gene 208, 25-30. https://doi.org/10.1016/S0378-1119(97)00633-1
  9. Berditchevski, F. and Odintsova, E. (2007) Tetraspanins as regulators of protein trafficking. Traffic 8, 89-96. https://doi.org/10.1111/j.1600-0854.2006.00515.x
  10. Charrin, S., le Naour, F., Silvie, O., Milhiet, P. E., Boucheix, C. and Rubinstein, E. (2009) Lateral organization of membrane proteins: tetraspanins spin their web. Biochem. J. 420, 133-154. https://doi.org/10.1042/BJ20082422
  11. Choi, S., Lee, S. A., Kwak, T. K., Kim, H. J., Lee, M. J., Ye, S. K., Kim, S. H., Kim, S. and Lee, J. W. (2009) Cooperation between integrin $\alpha{5}$ and tetraspan TM4SF5 regulates VEGF-mediated angiogenic activity. Blood 113, 1845-1855. https://doi.org/10.1182/blood-2008-05-160671
  12. Lee, S. A., Kim, Y. M., Kwak, T. K., Kim, H. J., Kim, S., Kim, S. H., Park, K. H., Cho, M. and Lee, J. W. (2009) The extracellular loop 2 of TM4SF5 inhibits integrin $\alpha{2}$ on hepatocytes under collagen type I environment. Carcinogenesis 30, 1872-1879. https://doi.org/10.1093/carcin/bgp234
  13. Lee, S. A., Ryu, H. W., Kim, Y. M., Choi, S., Lee, M. J., Kwak, T. K., Kim, H. J., Cho, M., Park, K. H. and Lee, J. W. (2009) Blockade of four-transmembrane L6 family member 5 (TM4SF5)-mediated tumorigenicity in hepatocytes by a synthetic chalcone derivative. Hepatology 49, 1316-1325. https://doi.org/10.1002/hep.22777
  14. Choi, Y. J., Kim, H. H., Kim, J. G., Kim, H. J., Kang, M., Lee, M. S., Ryu, J., Song, H. E., Nam, S. H., Lee, D., Kim, K. W. and Lee, J. W. (2014) TM4SF5 suppression disturbs integrin $\alpha{5}$-related signaling and muscle development in zebrafish. Biochem. J. 462, 89-101. https://doi.org/10.1042/BJ20140177
  15. Lee, S. Y., Kim, Y. T., Lee, M. S., Kim, Y. B., Chung, E., Kim, S. and Lee, J. W. (2006) Focal adhesion and actin organization by a cross-talk of TM4SF5 with integrin $\alpha{2}$ are regulated by serum treatment. Exp. Cell Res. 312, 2983-2999. https://doi.org/10.1016/j.yexcr.2006.06.001
  16. Lee, M. S., Kim, H. P., Kim, T. Y. and Lee, J. W. (2012) Gefitinib resistance of cancer cells correlated with TM4SF5-mediated epithelial-mesenchymal transition. Biochim. Biophys. Acta. 1823, 514-523. https://doi.org/10.1016/j.bbamcr.2011.11.017
  17. Kang, M., Choi, S., Jeong, S. J., Lee, S. A., Kwak, T. K., Kim, H., Jung, O., Lee, M. S., Ko, Y., Ryu, J., Choi, Y. J., Jeong, D., Lee, H. J., Ye, S. K., Kim, S. H. and Lee, J. W. (2012) Cross-talk between TGFb1 and EGFR signalling pathways induces TM4SF5 expression and epithelial-mesenchymal transition. Biochem. J. 443, 691-700. https://doi.org/10.1042/BJ20111584
  18. Kang, M., Jeong, S. J., Park, S. Y., Lee, H. J., Kim, H. J., Park, K. H., Ye, S. K., Kim, S. H. and Lee, J. W. (2012) Antagonistic regulation of transmembrane 4 L6 family member 5 attenuates fibrotic phenotypes in $CCl_4$-treated mice. FEBS. J. 279, 625-635. https://doi.org/10.1111/j.1742-4658.2011.08452.x
  19. Sangiovanni, A., Del Ninno, E., Fasani, P., De Fazio, C., Ronchi, G., Romeo, R., Morabito, A., De Franchis, R. and Colombo, M. (2004) Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance. Gastroenterology 126, 1005-1014. https://doi.org/10.1053/j.gastro.2003.12.049
  20. Severi, T., van Malenstein, H., Verslype, C. and van Pelt, J. F. (2010) Tumor initiation and progression in hepatocellular carcinoma: risk factors, classification, and therapeutic targets. Acta. Pharmacol. Sin. 31, 1409-1420. https://doi.org/10.1038/aps.2010.142
  21. Ghosh, A. K., Quaggin, S. E. and Vaughan, D. E. (2013) Molecular basis of organ fibrosis: potential therapeutic approaches. Exp. Biol. Med (Maywood). 238, 461-481. https://doi.org/10.1177/1535370213489441
  22. Meindl-Beinker, N. M., Matsuzaki, K. and Dooley, S. (2012) TGF-beta signaling in onset and progression of hepatocellular carcinoma. Dig. Dis. 30, 514-523. https://doi.org/10.1159/000341704
  23. Mantovani, A., Savino, B., Locati, M., Zammataro, L., Allavena, P. and Bonecchi, R. (2010) The chemokine system in cancer biology and therapy. Cytokine. Growth. Factor. Rev. 21, 27-39. https://doi.org/10.1016/j.cytogfr.2009.11.007
  24. Ryu, J., Kang, M., Lee, M. S., Kim, H. J., Nam, S. H., Song, H. E., Lee, D. and Lee, J. W. (2014) Cross-talk between the TM4SF5/FAK and the IL6/STAT3 pathways renders immune escape of human liver cancer cells. Mol. Cell Biol. 34, 2946-2960. https://doi.org/10.1128/MCB.00660-14
  25. Kang, M., Ryu, J., Lee, D., Lee, M. S., Kim, H. J., Nam, S. H., Song, H. E., Choi, J., Lee, G. H., Kim, T. Y., Lee, H., Kim, S. J., Ye, S. K., Kim, S. and Lee, J. W. (2014) Correlations between Transmembrane 4 L6 family member 5 (TM4SF5), CD151, and CD63 in liver fibrotic phenotypes and hepatic migration and invasive capacities. PLoS ONE 9, e102817. doi: 10.1371/journal.pone.0102817.
  26. Lietha, D., Cai, X., Ceccarelli, D. F., Li, Y., Schaller, M. D. and Eck, M. J. (2007) Structural basis for the autoinhibition of focal adhesion kinase. Cell 129, 1177-1187. https://doi.org/10.1016/j.cell.2007.05.041
  27. Jung, O., Choi, S., Jang, S. B., Lee, S. A., Lim, S. T., Choi, Y. J., Kim, H. J., Kim, D. H., Kwak, T. K., Kim, H., Kang, M., Lee, M. S., Park, S. Y., Ryu, J., Jeong, D., Cheong, H. K., Park, K. H., Lee, B. J., Schlaepfer, D. D. and Lee, J. W. (2012) Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells. J. Cell Sci. 125, 5960-5973. https://doi.org/10.1242/jcs.100586
  28. Jung, O., Choi, Y. J., Kwak, T. K., Kang, M., Lee, M. S., Ryu, J., Kim, H. J. and Lee, J. W. (2013) The COOH-terminus of TM4SF5 in hepatoma cell lines regulates c-Src to form invasive protrusions via EGFR Tyr845 phosphorylation. Biochim. Biophys. Acta. 1833, 629-642. https://doi.org/10.1016/j.bbamcr.2012.11.026

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