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Cancer Pain Control for Advanced Cancer Patients by Using Autonomic Nerve Pharmacopuncture

  • Kang, Hwi-Joong (East-West Cancer Center, Dunsan Korean Medical Hospital of Daejeon University) ;
  • Yoon, Jung-Won (East-West Cancer Center, Dunsan Korean Medical Hospital of Daejeon University) ;
  • Park, Ji-Hye (East-West Cancer Center, Dunsan Korean Medical Hospital of Daejeon University) ;
  • Cho, Chong-Kwan (East-West Cancer Center, Dunsan Korean Medical Hospital of Daejeon University) ;
  • Yoo, Hwa-Seung (East-West Cancer Center, Dunsan Korean Medical Hospital of Daejeon University)
  • Received : 2014.08.20
  • Accepted : 2014.08.29
  • Published : 2014.09.30

Abstract

Objectives: The purpose of this study is to report a case series of advanced cancer patients whose cancer pain was relieved by using autonomic nerve pharmacopuncture (ANP) treatment. ANP is a subcutaneous injection therapy of mountain ginseng pharmacopuncture (MGP) along the acupoints on the spine (Hua-Tuo-Jia-Ji-Xue; 0.5 cun lateral to the lower border of the spinous processes of vertebrae) to enhance the immune system and to balance autonomic nerve function. Methods: Patients with three different types of cancer (gastric cancer, lung cancer, colon cancer with distant metastases) with cancer pain were treated with ANP. 1 mL of MGP was injected into the bilateral Hua-Tuo-Jia-Ji-Xue on the T1-L5 sites (total 12-20 mL injection) of each patient's dorsum by using the principle of symptom differentiation. During ANP treatment, the visual analogue scale (VAS) for pain was used to assess their levels of cancer pain; also, the dosage and the frequency of analgesic use were measured. Results: The cancer pain levels of all three patients improved with treatment using ANP. The VAS scores of the three patients decreased as the treatment progressed. The dosage and the frequency of analgesics also gradually decreased during the treatment period. Significantly, no related adverse events were found. Conclusion: ANP has shown benefit in controlling cancer pain for the three different types of cancer investigated in this study and in reducing the dosage and the frequency of analgesics. ANP is expected to be beneficial for reducing cancer pain and, thus, to be a promising new treatment for cancer pain.

Keywords

References

  1. Marcus DA. Epidemiology of cancer pain. Curr Pain Headache Rep. 2011;15:231-4. https://doi.org/10.1007/s11916-011-0208-0
  2. Shaheen PE, Legrand SB, Walsh D, Estfan B, Davis MP, Lagman RL, et al. Errors in opioid prescribing: a prospective survey in cancer pain. J Pain Symptom Man. 2010;39(4):702-11. https://doi.org/10.1016/j.jpainsymman.2009.09.009
  3. Goudas LC, Bloch R, Gialeli-Goudas M, Lau J, Carr DB. The epidemiology of cancer pain. Cancer Invest. 2005;23(2):182-90. https://doi.org/10.1081/CNV-50482
  4. Lu W, Dean-Clower E, Doherty-Gilman A, Rosenthal DS. The value of acupuncture in cancer care. Hematol Oncol Clin North Am. 2008;22(4):631-48. https://doi.org/10.1016/j.hoc.2008.04.005
  5. O Regan D, Filshie J. Acupuncture and cancer. Auton Neurosci. 2010;157(1-2):96-100. https://doi.org/10.1016/j.autneu.2010.05.001
  6. Korean institute of herbal acupuncture. [Pharmacopuncturology]. 1sted. Seoul: ELSEVIER; 2008; p. 3-5, 229-29. Korean.
  7. Park BK, Cho JH, Son CG. Randomized clinical controlled trials with herbal acupuncture (pharmacopuncture) in Korea - a systematic review. J Korean Oriental Medicine. 2009;30(5):115-26.
  8. Yoo HS, Cho JH, Cho CK. [Effects of herbal acupuncture (soyeum) on cancer patients accompanied by pain]. J Pharmacopunct. 2003;6(1):16-7. Korean. https://doi.org/10.3831/KPI.2003.6.1.016
  9. Yoo HS, Kim JS. [The effect of sweet bee venom pharmacopuncture (SBVP) on cancer-related pain: a randomized controlled trial and double blinded - pilot study]. J Pharmacopunct. 2008;11(1):21-9. Korean. https://doi.org/10.3831/KPI.2008.11.1.021
  10. Lim SY, Lee SJ, Kwon KR. Anti-cancer and immune promoting effects of cultivated wild ginseng herbal acupuncture on hepatic metastatic model using colon26-L5 carcinoma cells. J Korean Acupunct Mox. 2006;23(1):121−34.
  11. Lee JH, Kwon KR, Cho CK, Han SS, Yoo HS. Advanced cancer cases treated with cultivated wild gin-seng pharmacopuncture. J Acupunct Meridian Stud. 2010;3(2):119−24. https://doi.org/10.1016/S2005-2901(10)60022-2
  12. Han JB, Im CR, Lee JW, Kim SS, Seong S. A case of inoperable klatskin tumor showing response to wild ginseng pharmacopuncture, Orient Pharm Exp Med. 2013;13(3):235-7. https://doi.org/10.1007/s13596-013-0130-6
  13. Heo TY, Wang YM. [Huatuojiajizhibaibing]. Beijing:Zzhongguoyiyaokejichubanshe; 2007. 25 p. Chinese.
  14. Clark D. 'Total pain', disciplinary power and the body in the work of cicely saunders. Soc Sci Med. 1999;49(6):727-36. https://doi.org/10.1016/S0277-9536(99)00098-2
  15. Kaptchuk TJ, Stason WB, Davis RB, Legedza ART, Schnyer RN, Kerr CE, et al. Sham device v inert pill:randomised controlled trial of two placebo treatments. BMJ. 2006;332:391–7. https://doi.org/10.1136/bmj.38726.603310.55
  16. Kwon YD, Pittler MH, Ernst E. Acupuncture for peripheral joint osteoarthritis: a systematic review and meta-analysis. Rheumatology (Oxford Journals). 2006;45(11):1331–7. https://doi.org/10.1093/rheumatology/kel207
  17. Furlan A.D, van Tulder MW, Cherkin DC, Tsukayama H, Lao L, Koes BW, et al. Acupuncture and dry-needling for low back pain. Cochrane Database Syst Rev. 2005;25(1):CD001351.
  18. White A, Foster NE, Cummings M, Barlas P. Acupuncture treatment for chronic knee pain: a systematic review. Rheumatology (Oxford Journals). 2007;46(3):384-90. https://doi.org/10.1093/rheumatology/kel413
  19. Manheimer E, Linde K, Lao L, Bouter LM, Berman BM. Meta-analysis: acupuncture for osteoarthritis of the knee. Ann Intern Med. 2007;146(12):868-77. https://doi.org/10.7326/0003-4819-146-12-200706190-00008
  20. Green S, Buchbinder R, Hetrick S. Acupuncture for shoulder pain. Cochrane Database Syst Rev. 2005;18(2):CD005319.
  21. Trinh K, Graham N, Gross A, Goldsmith CH, Wang E, Cameron ID, et al. Acupuncture for neck disorders. Cochrane Database Syst Rev. 2006;19(3):CD004870.
  22. Garcia MK, Driver L, Haddad R, Lee R, Palmer JL, Wei Q. et al. Acupuncture for treatment of uncontrolled pain in cancer patients: a pragmatic pilot study. Integr Cancer Ther. 2014;13(2):133-40. https://doi.org/10.1177/1534735413510558
  23. Wong RH, Lee TW, Sihoe AD, Wan IY, Ng CS, Chan SK, et al. Analgesic effect of electroacupuncture in postthoracotomy pain: a prospective randomized trial. Ann Thorac Surg. 2006;81(6):2031-6. https://doi.org/10.1016/j.athoracsur.2005.12.064
  24. Mehling WE, Jacobs B, Acree M, Wilson L, Bostrom A, West J, et al. Symptom management with massage and acupuncture in postoperative cancer patients: a randomized controlled trial. J Pain Symptom Manage. 2007;33(3):258-66. https://doi.org/10.1016/j.jpainsymman.2006.09.016
  25. Goldman N, Chen M, Fujita T, Xu Q, Peng W, Liu W, et al. Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. Nat Neurosci. 2010;13(7):883-8. https://doi.org/10.1038/nn.2562
  26. Zhu J, Jiang Y, Wu L, Xu G, Liu X. Suppression of local inflammation contributes to the neuroprotective effect of ginsenoside Rb1 in rats with cerebral ischemia. Neuroscience. 2012;202:342-51. https://doi.org/10.1016/j.neuroscience.2011.11.070

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