Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
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Mesenchymal stem cells transplantation for neuroprotection in preterm infants with severe intraventricular hemorrhage

  • Ahn, So Yoon (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Chang, Yun Sil (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Park, Won Soon (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • 투고 : 2014.03.16
  • 심사 : 2014.05.09
  • 발행 : 2014.06.10
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초록

Severe intraventricular hemorrhaging (IVH) in premature infants and subsequent posthemorrhagic hydrocephalus (PHH) causes significant mortality and life-long neurological complications, including seizures, cerebral palsy, and developmental retardation. However, there are currently no effective therapies for neonatal IVH. The pathogenesis of PHH has been mainly explained by inflammation within the subarachnoid spaces due to the hemolysis of extravasated blood after IVH. Obliterative arachnoiditis, induced by inflammatory responses, impairs cerebrospinal fluid (CSF) resorption and subsequently leads to the development of PHH with ensuing brain damage. Increasing evidence has demonstrated potent immunomodulating abilities of mesenchymal stem cells (MSCs) in various brain injury models. Recent reports of MSC transplantation in an IVH model of newborn rats demonstrated that intraventricular transplantation of MSCs downregulated the inflammatory cytokines in CSF and attenuated progressive PHH. In addition, MSC transplantation mitigated the brain damages that ensue after IVH and PHH, including reactive gliosis, cell death, delayed myelination, and impaired behavioral functions. These findings suggest that MSCs are promising therapeutic agents for neuroprotection in preterm infants with severe IVH.

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참고문헌

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피인용 문헌

  1. Current Proceedings of Cerebral Palsy vol.24, pp.3, 2014, https://doi.org/10.3727/096368915x686931
  2. Challenges for intraventricular hemorrhage research and emerging therapeutic targets vol.21, pp.12, 2014, https://doi.org/10.1080/14728222.2017.1397628
  3. Mesenchymal Stem Cells: The Magic Cure for Intraventricular Hemorrhage? vol.26, pp.3, 2014, https://doi.org/10.3727/096368916x694193
  4. Application of mesenchymal stem cells in paediatrics vol.30, pp.3, 2017, https://doi.org/10.1515/cipms-2017-0022
  5. Blood–brain barrier and foetal-onset hydrocephalus, with a view on potential novel treatments beyond managing CSF flow vol.14, pp.1, 2014, https://doi.org/10.1186/s12987-017-0067-0
  6. Strategies to enhance paracrine potency of transplanted mesenchymal stem cells in intractable neonatal disorders vol.83, pp.1, 2018, https://doi.org/10.1038/pr.2017.249
  7. The Potentials and Caveats of Mesenchymal Stromal Cell-Based Therapies in the Preterm Infant vol.2018, pp.None, 2014, https://doi.org/10.1155/2018/9652897
  8. Migratory potential of transplanted glial progenitors as critical factor for successful translation of glia replacement therapy: The gap between mice and men vol.66, pp.5, 2018, https://doi.org/10.1002/glia.23275
  9. Human Cord Blood-Derived Unrestricted Somatic Stem Cell Infusion Improves Neurobehavioral Outcome in a Rabbit Model of Intraventricular Hemorrhage vol.8, pp.11, 2014, https://doi.org/10.1002/sctm.19-0082
  10. Exosomes derived from umbilical cord mesenchymal stem cells reduce microglia-mediated neuroinflammation in perinatal brain injury vol.10, pp.1, 2019, https://doi.org/10.1186/s13287-019-1207-z
  11. Neural stem cell therapy of foetal onset hydrocephalus using the HTx rat as experimental model vol.381, pp.1, 2014, https://doi.org/10.1007/s00441-020-03182-0
  12. Retrieval of germinal zone neural stem cells from the cerebrospinal fluid of premature infants with intraventricular hemorrhage vol.9, pp.9, 2020, https://doi.org/10.1002/sctm.19-0323
  13. Mesenchymal Stem Cell Therapy for Intractable Neonatal Disorders vol.32, pp.3, 2014, https://doi.org/10.14734/pn.2021.32.3.105
  14. Brain-derived neurotropic factor mediates neuroprotection of mesenchymal stem cell-derived extracellular vesicles against severe intraventricular hemorrhage in newborn rats vol.10, pp.3, 2021, https://doi.org/10.1002/sctm.20-0301
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