Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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Vitamin D deficiency in women with polycystic ovary syndrome

  • Kim, Jin Ju (Department of Obstetrics and Gynecology, Healthcare System Gangnam Center, Seoul National University Hospital) ;
  • Choi, Young Min (The Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine) ;
  • Chae, Soo Jin (Department of Obstetrics and Gynecology, Maria Fertility Hospital) ;
  • Hwang, Kyu Ri (Department of Obstetrics and Gynecology, Seoul National University College of Medicine) ;
  • Yoon, Sang Ho (Department of Obstetrics and Gynecology, Graduate School of Medicine, Dongguk University) ;
  • Kim, Min Jeong (Department of Obstetrics and Gynecology, Healthcare System Gangnam Center, Seoul National University Hospital) ;
  • Kim, Sun Mie (Department of Obstetrics and Gynecology, Healthcare System Gangnam Center, Seoul National University Hospital) ;
  • Ku, Seung Yup (The Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine) ;
  • Kim, Seok Hyun (The Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine) ;
  • Kim, Jung Gu (Department of Obstetrics and Gynecology, Seoul National University College of Medicine)
  • Received : 2014.05.15
  • Accepted : 2014.06.06
  • Published : 2014.06.30
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Abstract

Objective: To investigate: the prevalence of vitamin D deficiency in Korean women with polycystic ovary syndrome (PCOS), and the relationship between vitamin D status and clinical or metabolic features in this group. Methods: We recruited 38 women with PCOS using the Rotterdam criteria. A total of 109 premenopausal control women were matched with patients based on age and body mass index. Serum 25-hydroxy vitamin D concentrations less than 20 ng/mL were classified as frank vitamin D deficiency. Since vitamin D may play a significant role in metabolic disturbances in women with PCOS, correlations between clinical or metabolic parameters and vitamin D status were analyzed separately in patients and controls. Results: Women with PCOS showed no differences in the level of 25-hydroxy vitamin D ($19.6{\pm}6.6ng/mL$ in patients vs. $20.1{\pm}7.4ng/mL$ in controls, respectively, p=0.696) or prevalence of vitamin D deficiency (57.9% in patients vs. 56.5% in controls, respectively, p=0.880). In addition, we did not find any correlations between serum vitamin D level and clinical or metabolic profiles in either PCOS patients or controls. Conclusion: Our study found no differences in the absolute level of serum vitamin D between PCOS patients and matched controls. Prevalence of vitamin D deficiency was equally common among both patients and controls. Additionally, we did not find any correlations between serum vitamin D level and clinical or metabolic profiles, suggesting that the role of vitamin D in the pathogenesis of PCOS is not yet clear.

Keywords

References

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