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Rg3-enriched Korean Red Ginseng improves vascular function in spontaneously hypertensive rats

  • Park, Jung-Bum (Department of Physiology, School of Medicine, Chungnam National University) ;
  • Kwon, Sun Kwan (Department of Physiology, School of Medicine, Chungnam National University) ;
  • Nagar, Harsha (Department of Physiology, School of Medicine, Chungnam National University) ;
  • Jung, Saet-Byel (Department of Endocrinology, Chungnam National University Hospital) ;
  • Jeon, Byeong Hwa (Department of Physiology, School of Medicine, Chungnam National University) ;
  • Kim, Chang Sup (Department of Chemical and Biological Engineering, Hanbat National University) ;
  • Oh, Jin-Hwan (BTGin Company Limited) ;
  • Song, Hee-Jung (Department of Neurology, Chungnam National University Hospital) ;
  • Kim, Cuk-Seong (Department of Physiology, School of Medicine, Chungnam National University)
  • Received : 2014.03.20
  • Accepted : 2014.05.30
  • Published : 2014.10.15

Abstract

Background: Panax ginseng has distinct and impressive health benefits, such as improved blood pressure and immune system functioning. Rg3-enriched Korean Red Ginseng (REKRG) isolated from Korean Red Ginseng contains a high percentage of Rg3. Methods: In this study, we examined the effects of REKRG on endothelial cell nitric oxide synthase (eNOS) activation and adhesion molecules in endothelial cells and vascular function in rats. Results: REKRG dose-dependently increased eNOS phosphorylation and nitric oxide (NO) production in endothelial cells. In addition, REKRG markedly inhibited the tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$)-mediated induction of intercellular adhesion molecule (ICAM)-1 and cyclooxygenase (COX)-2 expressions in endothelial cells. REKRG improved endothelium-dependent vasorelaxation in the Wistar-Kyoto (WKY) rat and spontaneously hypertensive rats (SHRs) compared with controls. Furthermore, REKRG treatment for 6 weeks increased serum NO levels and reduced the mean aortic intima-media thickness compared with controls. Conclusion: Taken together, these results suggest that REKRG increased vascular function and improved immune system functioning. Therefore, REKRG is a very useful food for preventing or improving various cardiovascular diseases.

Keywords

References

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