Journal of Environmental Health Sciences (한국환경보건학회지)

Korean Society of Environmental Health (한국환경보건학회)
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Human Risk Assessment of Perchloroethylene Considering Multi-media Exposure

다매체 노출을 고려한 Perchloroethylene의 인체위해성평가연구

  • Seo, Jungkwan (National Institute of Environmental Research) ;
  • Kim, Taksoo (National Institute of Environmental Research) ;
  • Jo, Areum (National Institute of Environmental Research) ;
  • Kim, Pilje (National Institute of Environmental Research) ;
  • Choi, Kyunghee (National Institute of Environmental Research)
  • Received : 2014.09.29
  • Published : 2014.10.31
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Abstract

Objectives: Perchloroethylene (PCE) is a volatile chemical widely used as a solvent in the dry-cleaning and textile processing industries. It was evaluated as Group 2 "probably carcinogenic to humans" by the Integrated Risk Information System (IRIS) of the United State Environmental Protection Agency (U.S. EPA) in 2012. In order to provide a scientific basis for establishing risk management measures for chemicals on the national priority substances list, aggregate risk assessment was conducted for PCE, included in the top-10 substances. Methods: We conducted the investigation and monitoring of PCE exposure (e.g., exposure scenario, detection levels, and exposure factors, etc.) and assessed its multi-media (e.g., outdoor air, indoor air, and ground water) exposure risk with a deterministic and probabilistic approach. Results: In human risk assessment (HRA), the level of human exposure was higher in the younger age group. The exposure level through inhalation at home was the highest among the exposure routes. Outdoor air or uptake of drinking water represented less than 1% of total contributions to PCE exposure. These findings suggested that the level of risk was negligible since the Hazard Index (HI) induced by HRA was below one among all age groups, with a maximum HI value of 0.17 when reasonable maximum exposure was applied. Conclusion: In conclusion, it was suggested that despite low exposure risk, further studies are needed considering main sources, including occupational exposure.

Keywords

References

  1. Rastkari N, Yunesian M, Ahmadkhaniha, R. Exposure assessment to trichloroethylene and perchloroethylene for workers in the dry cleaning industry. Bull Environ Contam Toxicol. 2011; 86: 363-367. https://doi.org/10.1007/s00128-011-0244-9
  2. Labreche FP and Goldberg MS. Exposure to organic solvents and breast cancer in women: a hypothesis. Am J Ind Med. 1997; 32:1-14. https://doi.org/10.1002/(SICI)1097-0274(199707)32:1<1::AID-AJIM1>3.0.CO;2-3
  3. Guyton KZ, Hogan KA, Scott CS, Cooper GS, Bale AS, Kopylev L, et al. Human health effects of tetrachloroethylene: Key findings and scientific issues. Environ Health Perspect. 2014; 122(4): 325-334.
  4. Raaschou-Nielsen O, Hansen J, Christensen JM, Blot WJ, McLaughlin JK, Olsen JH. Urinary concentrations of trichloroacetic acid in Danish workers exposed to trichloroethylene. 1947-1985. Am J Ind Med. 2001; 39: 320-327. https://doi.org/10.1002/1097-0274(200103)39:3<320::AID-AJIM1020>3.0.CO;2-8
  5. Mundt KA, Birk T, Burch MT. Critical review of the epidemiological literature on occupational exposure to perchloroethylene and cancer. Int Arch Occup Environ Health. 2003; 76: 473-491. https://doi.org/10.1007/s00420-003-0457-2
  6. Aschengrau A, Weinberg JM, Janulewicz PA, Romano ME, Gallagher LG, Winter MR, et al. Affinity for risky behaviors following prenatal and early childhood exposure to tetrachloroethylene (pce)-contaminated drinking water: A retrospective cohort study. Environ Health. 2011; 10: 1-13. https://doi.org/10.1186/1476-069X-10-1
  7. International Agency for Research on Cancer, tetrachloroethylene. 1995; Available: http://monographs.iarc.fr/ENG/Publications/techrep42/TR42-15.pdf [accessed 22 November 2012].
  8. New York State Department of Health. Tetrachloroethylene ambient air criteria document. New York State Department of Health. Available: http://www.health.state.ny.us/nysdoh/environ/btsa/fs_perc.htm [assessed 13 Novemver 2012].
  9. New York State Department of Health. Fact Sheet: Tetrachloroethylene (Perc) indoor and outdoor air. New York State Department of Health. Available: http://www.health.st.ate.ny.us/nysdoh/environ/btsa/fs_perc.pdf [assessed 13 November 2012].
  10. Ministry of Environment. Regulation of hazardous chemicals law.Sejong: Ministry of Environment Press; 2013.
  11. National Institute of Environment Research. A study on the contribution of petroleum solvent to air pollution. Available: http://www.webbook.me.go.kr/DLi-File/F000/086/8635_62206.pdf [assessed 27 August 2012].
  12. Kim YH, Yang WH and Son BS. Estimation of total exposure to benzene, toluene and xylene by microenvironmental measurements for iron mill workers. J Environ Health Sci. 2007; 33(5): 359-364. https://doi.org/10.5668/JEHS.2007.33.5.359
  13. US Environmental Protection Agency. Integrated risk information system. Available: http://www.epa.gov/IRIS [accessed 27 November 2012].
  14. European chemical substances information system. Available: http://www.esis.jrc.ec.europa.eu [accessed 25 September 2012].
  15. Jang JY, Jo SN, Kim SY, Kim SJ, Jung HK. Korean exposure factors handbook. Ministry of Environment Press; 2007.
  16. US Environmental Protection Agency. Exposure factors handbook. 2011. Available: http://www.epa.gov/ncea/efh/pdfs/efh-complete.pdf [accessed 25 September 2012].
  17. US Environmental Protection Agency. Risk assessment guidance for superfund volume: Human health evaluation manual (Part A) Available: http://www.epa.gov/oswer/riskassessment/ragsa/pdf/rags_a.pdf [assessed 17 October 2012].
  18. National Industrial Chemicals Notification and Assessment Scheme. Tetrachloroethylene: Priority Existing Chemical Assessment Report No. 15. Available: http://www.nicnas.gov.au/_data/assets/pdf_file/0020/4376/ PEC_15_Tetrachloroethylene_Full_Report_PDF.pdf [assessed 12 November 2012].
  19. Riihimaki V and Pfaffli P. Percutaneous absorption of solvent vapours in man. Scand J Work Environ Health.1978; 4:73-85. https://doi.org/10.5271/sjweh.2721
  20. Agency for Toxic Substances and Disease Registry. Toxicological Profile for Tetrachloroethylene, U.S Department of Health and Human Services Public Health Service. Available: http://www.atsdr.cdc.gov/toxprofiles/tp18.pdf [accessed 26 November 2012].
  21. American Conference of Industrial Hygienists. Available: http://www.acgih.org [accessed 25 September 2012].
  22. National Cancer Institute. Bioassay of tetrachloroethylene for possible carcinogenicity. CAS No. 127-18-4. NCI-CGTR-13; DHEW Publication No. (NIH) 77-813. Bethesda, Md. Available: http://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/tr013.pdf [accessed 30 July 2014].
  23. National Toxicology Program. Toxicology and carcinogenesis studies of tetrachloroethylene (perchloroethylene) CAS No. 127-18-4 in F344/N rats and B6C3F1 mice (Inhalation studies). TR 311. Research triangle park, NC: Available: http://www.ntp.niehs.nih.gov/ntp/htdocs/lt_rptss/tr300.pdf [accessed 30 July 2014].
  24. Japan Industrial Safety and Health Association. Carcinogenicity study of tetrachloroethylene by inhalation in rats and mice. Available: http://www.epa.gov/iris/supdocs/0106index.html [accessed 31 July 2014].
  25. Stewart RD, Baretta ED, Dodd HC, Torkelson TR. Experimental human exposure to tetrachloroethylene. Arch Environ Health. 1970; 20: 224-229. https://doi.org/10.1080/00039896.1970.10665578
  26. Anttila A, Pukkala E, Sallmen M, Hernberg S, Hemminki K. Cancer incidence among Finnish workers exposed to halogenated hydrocarbons. J Occup Environ Med. 1995; 37: 797-806. https://doi.org/10.1097/00043764-199507000-00008
  27. Boice JD, Marano D, Fryzek J, Sadler C, MaLaughlin JK. Mortality among aircraft manufacturing workers. Occup Environ Med. 1999; 56: 581-597. https://doi.org/10.1136/oem.56.9.581
  28. Calvert GM, Ruder AM, Petersen MR. Mortality and endstage renal disease incidence among dry cleaning workers. Occup Environ Med. 2011; 68: 709-716. https://doi.org/10.1136/oem.2010.060665
  29. Radican L, Blair A, Stewart P, Wartenberg D. Mortality of aircraft maintenance workers exposed to trichloroethylene and other hydrocarbons and chemicals: extended follow-up. J Occup Environ Med. 2008; 50: 1306-1319. https://doi.org/10.1097/JOM.0b013e3181845f7f
  30. Selden AI and Ahlborg G. Cancer morbidity in Swedish dry cleaners and laundry workers: historically prospective cohort study. Int Arch Occup Environ Health. 2011; 84: 435-443. https://doi.org/10.1007/s00420-010-0582-7
  31. Operation results of hazardous air quality monitoring system. Ministry of Environment press; 2008-2010a.
  32. Operation results of water quality monitoring system in groundwater. Ministry of Environment press; 2008-2010b.
  33. Tap water quality reports by 6 metropolitan cities. Water service management agency press; 2009-2011.
  34. Statistics Korea. Time use survey. Available: http://www.kostat.go.kr/survey/lifestyle [assessed 15 October].
  35. World Health Organization. WHO guidelines for indoor air quality: Selected pollutants. Tetrachloroethylene. Avaliable: http://www.euro.who.int/_data/assets/pdf_file/0009/128169/e94535.pdf [assessed 19 August 2014].
  36. Jantunen MJ, Katsouyanni K, Kunzli N, Lebret E, Maroni M, Saarela K, et al. Air pollution exposure in European cities: the EXPOLIS study. Kuopio: National Public Health Institute; 1999. Available: http://www.thl.fi/expolis/files/final_report.pdf [assessed 16 October].
  37. Seo JK, Kim TS, Kim PJ. Aggregate risk assessment on xylene and ethylbenzene. J Environ Sci Inter. 2013; 22(2): 163-171. https://doi.org/10.5322/JESI.2013.22.2.163
  38. Scheuplein R, Charnley G, Dourson M. Differential sensitivity of children and adults to chemical toxicity: I. Biological basis. Regul Toxicol Pharmacol. 2002; 35(3): 429-447. https://doi.org/10.1006/rtph.2002.1558
  39. International Agency for Research on Cancer, tetrachloroethylene. 1995; Available: http://www.inchem.org/ documents/iarc/vol63/tetrachloroethylene.html [accessed 27 November 2012].
  40. Emara AM, EI-Noor MMA, Hassan NA, Wagih AA. Immunotoxicity and hematotoxicity induced by tetrachloroethylene in egyptiandry cleaning workers. Inhal Toxicol. 2010; 22(2): 117-124.
  41. Kwon MH, Jang SK, Ryu JM, Seo SY, Won SR, Jung SJ et al. A study on management of major indoor air pollutants by house type in Korea(I): Indoor air pollution and health effects in residential apartment. National Institute of Environmental Research Press; 2009.