Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
권호 표지
DOI QR코드

DOI QR Code

Whitening and Anti-wrinkle Effects of Korean Native Dendrobium moniliforme Methanol Extract

한국 자생 석곡 메탄올 추출물의 미백 및 주름개선 효과

  • Jung, Ho Kyung (Jeollanamdo Development Institute of Korean Traditional Medicine) ;
  • Jang, Ji Hun (Jeollanamdo Development Institute of Korean Traditional Medicine) ;
  • Ko, Jae Hyung (Jeollanamdo Development Institute of Korean Traditional Medicine) ;
  • Kang, Byoung Man (Jeollanamdo Development Institute of Korean Traditional Medicine) ;
  • Yeo, Jun Hwan (Jeollanamdo Development Institute of Korean Traditional Medicine) ;
  • Cho, Jung Hee (Jeollanamdo Development Institute of Korean Traditional Medicine) ;
  • Cho, Hyun Woo (Jeollanamdo Development Institute of Korean Traditional Medicine) ;
  • Bean, Chul Gu (Research Institute, Gyeongsangnam-do Agricultural Research & Extension Services) ;
  • Kim, Seong Cheol (Namhae Sub-Station, NIHHS, RDA) ;
  • Jung, Won Seok (Jeollanamdo Development Institute of Korean Traditional Medicine)
  • Received : 2014.07.08
  • Accepted : 2014.07.31
  • Published : 2014.10.30
Download PDF
⟨ Previous Next ⟩

Abstract

Dendrobium moniliforme (DM) is a valuable and versatile herbal medicine with the anecdotal claims of antioxidant and anti-inflammation. In the present study, we investigated the whitening and anti-wrinkling effects of DM under various conditions with B16F10 melanoma cells and human dermal fibroblasts. The DM extract inhibited melanin contents and tyrosinase activity in a dose-dependent manner, compared with untreated group. Treatment of the DM extract effectively suppressed the ${\alpha}$-MSH-stimulated melanin formation, tyrosinase activity and dendrite outgrowth. Moreover, the ${\alpha}$-MSH-induced mRNA expressions of tyrosinase-related protein-1 (TRP-1) and tyrosinase-related protein-2 (TRP-2) and protein expression of tyrosinase were significantly attenuated by DM treatment. We also investigated the DM increased the production of type I procollagen and inhibited TNF-${\alpha}$-induced mRNA expressions of MMP-1, -3 in the human dermal fibroblast. These results indicate that DM may be a great cosmeceutical ingredient for its whitening and anti-wrinkle effects.

Keywords

References

  1. Bradford MM. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry. 72:248-254. https://doi.org/10.1016/0003-2697(76)90527-3
  2. Choi GP, Chung BH, Lee DI, Lee HY, Lee JH and Kim JD. (2002). Screening of inhibitory activities on angiotensin converting enzyme from medicinal plants. Korean Journal of Medicinal Crop Sciences. 10:399-402.
  3. Choung MG, Hwang YS, Kim GP, Ahn KG, Shim HS, Hong SB, Choi JH, Yu CY, Chung IM, Kim SH and Lim JD. (2013). Antimelanogenic effect and whitening of anthocyanin rich fraction from seeds of Liriope platyphylla. Korean Journal of Medicinal Crop Sciences. 21:361-371. https://doi.org/10.7783/KJMCS.2013.21.5.361
  4. Elliott S, Hays E, Mayor M, Sporn M and Vincenti M. (2003). The triterpenoid CDDO inhibits expression of matrix metalloproteinase-1, matrix metalloproteinase-13 and Bcl-3 in primary human chondrocytes. Arthritis Research & Therapy. 5:285-291. https://doi.org/10.1186/ar792
  5. Fisher GJ, Talwar HS, Lin J and Voorhees JJ. (1999). Molecular mechanisms of photoaging in human skin in vivo and their prevention by all-trans retinoic acid. Photochemistry and Photobiology. 69:154-157. https://doi.org/10.1111/j.1751-1097.1999.tb03268.x
  6. Hemesath TJ, Price ER, Takemoto C, Badalian T and Fisher DE. (1998). MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes. Nature. 391:298-301. https://doi.org/10.1038/34681
  7. Kim DS, Jeon BK, Lim NY, Mun YJ, Lee YE and Woo WH. (2013). Ethanol extract of Dioscorea batatas stimulates procollagen production and reduces UVB-induced MMPs activity in skin. Korean Journal of Oriental Physiology & Pathology. 27:183-188.
  8. Kim DH, Moon YS, Park TS, Hwang JY and Son JH. (2013). Potent whitening activity of Aruncus dioicus extract in B16F10 melanoma cell by suppression of melanin biosynthesis. Korean Journal of Horticultural Science & Technology. 31:813-820. https://doi.org/10.7235/hort.2013.13067
  9. Kim JS, Kim JW, Kwon HS, Lim HW and Lee HY. (2013). Screening of skin whitening activity of Codonopsis lanceolata extract by complex steaming process. Korean Journal of Medicinal Crop Sciences. 21:54-60. https://doi.org/10.7783/KJMCS.2013.21.1.54
  10. Kim TH, Kim JM, Baek JM, Kim TW, Kim DJ, Park JH and Choe M. (2011). Antioxidant and whitening effects of Agrimonia pilosa ledeb water extract. Korean Journal of Medicinal Crop Sciences. 19:177-184. https://doi.org/10.7783/KJMCS.2011.19.3.177
  11. Kim YG, Yang GH and Cho SI. (2005). Anti-oxidative effect of Dendrobii herba on toxic. The Korea Journal of Herbology. 20:55-60.
  12. Liu JJ and Fisher DE. (2010). Lighting a path to pigmentation: Mechanisms of MITF induction by UV. Pigment Cell & Melanoma Research. 23:741-745. https://doi.org/10.1111/j.1755-148X.2010.00775.x
  13. Lo SF, Mulabagal V, Chen CL, Kuo CL and Tsay HS. (2004). Bioguided fractionation and isolation of free radical scavenging components from in vitro propagated chinese medicinal plants Dendrobium tosaense Makino and Dendrobium moniliforme SW. Journal of Agricultural and Food Chemistry. 52:6916-6919. https://doi.org/10.1021/jf040017r
  14. Lee SY, An JH and Cho HY. (2003). Isolation and characterization of MMP-1 inhitor peptide from Crataegus pinnatifida Bunge in fibroblast cell line HS68 cells. Journal of the Korean Society for Applied Biological Chemistry. 46:60-65.
  15. Hwang BM, Roh SS and Seo HS. (2010). Effects of Dendrobii herba and pnica granatum extract on the anti-oxidant, antiinflammatory, anti-wrinkle and whitening. The Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology. 23:11-13.
  16. Olivares C and Solano F. (2009). New insights into the active site structure and catalytic mechanism of tyrosinase and its related proteins. Pigment Cell & Melanoma Research. 22:750-760. https://doi.org/10.1111/j.1755-148X.2009.00636.x
  17. Park HY, Kosmadaki M, Yaar M and Gilchrest BA. (2009). Cellular mechanisms regulating human melanogenesis. Cellular and Molecular Life Sciences. 66:1493-1506. https://doi.org/10.1007/s00018-009-8703-8
  18. Schiaffino MV. (2010). Signaling pathways in melanosome biogenesis and pathology. The International Journal of Biochemistry & Cell Biology. 42:1094-1104. https://doi.org/10.1016/j.biocel.2010.03.023
  19. Steenport M, Khan KM, Du B, Barnhard SE, Dannenberg AJ and Falcone DJ. (2009). Matrix metalloproteinase(MMP)-1 and MMP-3 induce macrophage MMP-9: Evidence for the role of TNF-a and cyclooxygenase-2. Journal of Immunology. 183:8119-8127. https://doi.org/10.4049/jimmunol.0901925
  20. Slominski A, Tobin DJ, Shibahara S and Wortsman J. (2004). Melanin pigmentation in mammalian skin and its hormonal regulation. Physiological Reviews. 84:1155-1228. https://doi.org/10.1152/physrev.00044.2003
  21. Ng TB, Liu J, Wong JH, Ye X, Wing Sze SC, Tong Y and Zhang KY. (2012). Review of research on Dendrobium, a prized folk medicine. Applied Microbiology and Biotechnology. 93:1795-1803. https://doi.org/10.1007/s00253-011-3829-7
  22. Thody AJ and Graham A. (1998). Does alpha-MSH have a role in regulating skin pigmentation in humans?. Pigment Cell Research. 11:265-274. https://doi.org/10.1111/j.1600-0749.1998.tb00735.x
  23. Unemori EN, Bair MJ, Bauer EA and Amento EP. (1991). Stromelysin expression regulates collagenase activation in human fibroblasts. Dissociable control of two metalloproteinases by interferon-gamma. The Journal of Biological Chemistry. 266:23477-23482.
  24. Wu M, Hemesath TJ, Takemoto CM, Horstmann MA, Wells AG, Price ER, Fisher DZ and Fisher DE. (2000). c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi. Genes & Development. 14:301-312.
  25. Bo Y, Chao J, Jian K, Wenqi C, Zhigang B and Yinsheng W. (2009). Trans-Zeatin inhibits UVB-induced matrix metalloproteinase-1 expression via MAP kinase signaling in human skin fibroblasts. International Journal of Molecular Medicine. 23:555-560.
  26. Yoon MY, Kim JY, Hwang JH, Cha MR, Lee MR, Jo KJ and Park HR. (2007). Protective effect of methanolic extracts from Dendrobium nobile Lindl. on $H_2O_2$-induced neurotoxicity in PC12 cells. Journal of the Korean Society for Applied Biological Chemistry. 50:63-67.

Cited by

  1. Whitening and Anti-Wrinkle Effects of Tremella fuciformis Extracts vol.24, pp.1, 2016, https://doi.org/10.7783/KJMCS.2016.24.1.38
  2. Effect of Dendrobium speciosum Var. Aqueous Extract on Loperamide-Induced Constipation in Rats vol.24, pp.1, 2016, https://doi.org/10.7783/KJMCS.2016.24.1.1
  3. Anti-melanogenesis and Anti-wrinkle Properties of Korean Native Dendrobium speciosum Ethanol Extract vol.29, pp.2, 2016, https://doi.org/10.7732/kjpr.2016.29.2.155