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Meningovascular and Spinal form of Neurosyphilis Presenting as Multiple Cranial Nerve Palsy, Cerebral Infarction and Meningomyelitis in a Human Immunodeficiency Virus Negative-Patient: MR Imaging Features

인간면역결핍바이러스 음성 환자에서 뇌신경 마비, 뇌경색 및 수막척수염으로 발현한 신경매독의 자기공명영상 소견

  • Hong, Jin Ho (Department of Radiology, Inha University School of Medicine) ;
  • Lee, Ha Young (Department of Radiology, Inha University School of Medicine) ;
  • Lim, Myung Kwan (Department of Radiology, Inha University School of Medicine) ;
  • Kang, Young Hye (Department of Radiology, Inha University School of Medicine) ;
  • Lee, Kyung Hee (Department of Radiology, Inha University School of Medicine) ;
  • Cho, Soon Gu (Department of Radiology, Inha University School of Medicine)
  • 홍진호 (인하대학교병원 영상의학과) ;
  • 이하영 (인하대학교병원 영상의학과) ;
  • 임명관 (인하대학교병원 영상의학과) ;
  • 강영혜 (인하대학교병원 영상의학과) ;
  • 이경희 (인하대학교병원 영상의학과) ;
  • 조순구 (인하대학교병원 영상의학과)
  • Received : 2014.07.30
  • Accepted : 2014.09.02
  • Published : 2014.09.30

Abstract

Neurosyphilis is a rare infection of the brain and spinal cord caused by a spirochete named Treponema pallidum. We describe the magnetic resonance imaging of a 53-year-old man with syphilis who manifested as both meningovascular, and spinal meningomyelitic types, which involved the optic, trigeminal, facial and vestibulocochlear nerves, both middle and left posterior cerebral arteries, thoracic spinal cord and meninges of the lumbar spine. This case report suggests that neurosyphilis should be considered as a possible diagnosis in patients showing complex brain and spinal imaging features. These features include enhancing meningeal lesions with multiple cranial nerve involvement, stenoses in large to medium size cerebral arteries, and intramedullary and meningeal lesions of spine.

신경매독은 스피로헤타(spirochete)인 Treponema pallidum에 의한 뇌와 척수의 드문 감염증이다. 저자들은 53세 남자환자에서 시신경, 삼차신경, 안면신경, 전정와우신경, 중뇌동맥, 후뇌동맥, 척수와 척수막을 침범한 복합적인 수막혈관성, 수막척수염 형태의 신경매독을 경험하여 이를 보고하고자 한다. 본 증례를 통해 뇌수막염과 더불어 뇌신경염, 뇌혈관염이 있고 수막척수염을 동반하는 복합적인 중추신경계 이상 소견이 있어 임상적인 진단이 어려운 경우 신경매독을 감별진단으로 고려하여 영상 소견을 바탕으로 한 빠른 진단이 필요함을 강조하고자 한다.

Keywords

References

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  1. Syphilitic meningitis presenting with multiple cranial neuropathies vol.14, pp.6, 2014, https://doi.org/10.1136/bcr-2021-241765