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Traditional topical herbal therapies in psoriasis

  • Keseroglu, Havva Ozge (Ankara Diskapi Yildirim Beyazit Education and Research Hospital, Dermatology Clinic) ;
  • Gonul, Muzeyyen (Ankara Diskapi Yildirim Beyazit Education and Research Hospital, Dermatology Clinic)
  • Received : 2014.09.11
  • Accepted : 2014.11.10
  • Published : 2014.11.30

Abstract

Psoriasis is a common, chronic, recurrent, immune-mediated inflammatory disorder of skin. Although conventional topical and systemic therapies yield remission for a while, they carry a risk of many side effects that limit the long term use of these agents and the disease recurs generally in a short period of time after cessation of therapy. An increasing number of psoriatic patients are using herbal products as a treatment to control their disease with less side effects. Clinicians should be aware of plants used in psoriasis and side effects related with them. The aim of this article is to review the different herbs used in psoriasis treatment.

Keywords

References

  1. Amenta R, Camarda L, Di Stefano V, Lentini F, Venza F. Traditional medicine as a source of new therapeutic agents against psoriasis. Fitoterapia. 2000;71:S13-S20. https://doi.org/10.1016/S0367-326X(00)00172-6
  2. Asawanonda P, Amornpinyokeit N, Nimnuan C. Topical 8-methoxypsoralen enhances the therapeutic results of targeted narrowband ultraviolet B phototherapy for plaque-type psoriasis. J Eur Acad Dermatol Venereol. 2008;22:50-55.
  3. Berneburg M, Herzinger T, Rampf J, Hoetzenecker W, Guenova E, Meisner C, Maetzke J, Schaefer T, Eberlein B, Scharffetter-Kochanek K, Rocken M. Efficacy of bath psoralen plus ultraviolet A (PUVA) vs. system PUVA in psoriasis: a prospective, open, randomized, multicentre study. Br J Dermatol. 2013;169:704-708. https://doi.org/10.1111/bjd.12466
  4. Bernstein S, Donsky H, Gulliver W, Hamilton D, Nobel S, Norman R. Treatment of mild to moderate psoriasis with Reliéva, a Mahonia aquifolium extract-a double-blind, placebo-controlled study. Am J Ther. 2006;13:121-126. https://doi.org/10.1097/00045391-200603000-00007
  5. Bernstein JE, Parish LC, Rapaport M, Rosenbaum MM, Roenigk HH Jr. Effects of topically applied capsaicin on moderate and severe psoriasis vulgaris. J Am Acad Dermatol. 1986;15:504-507. https://doi.org/10.1016/S0190-9622(86)70201-6
  6. Bezakova L, Misik V, Malekova L, Svajdlenka E, Kostalova D. Lipoxygenase inhibition and antioxidant properties of bisbenzylisoqunoline alkaloids isolated from Mahonia aquifolium. Pharmazie. 1996;51:758-761.
  7. Bylka W, Znajdek-Awiżen P, Studzinska-Sroka E, Brzezinska M. Centella asiatica in cosmetology. Postepy Dermatol Alergol. 2013;30:46-49.
  8. Brown AC, Koett J, Johnson DW, Semaskvich NM, Holck P, Lally D, Cruz L, Young R, Higa B, Lo S. Effectiveness of kukui nut oil as a topical treatment for psoriasis. Int J Dermatol. 2005;44:684-687. https://doi.org/10.1111/j.1365-4632.2005.02634.x
  9. Capella GL, Finzi AF. Complementary therapy for psoriasis. Dermatol Ther. 2003;16:164-174. https://doi.org/10.1046/j.1529-8019.2003.01625.x
  10. Choonhakarn C, Busaracome P, Sripanidkulchai B, Sarakarn P. A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis. J Eur Acad Dermatol Venereol. 2010;24:168-172. https://doi.org/10.1111/j.1468-3083.2009.03377.x
  11. Clark CM, Mckay RA, Fortune DG, Griffiths CE. Use of alternative treatments by patients with psoriasis. Br J Gen Pract. 1998;48:1873-1874.
  12. Dattner AM. From medical herbalism to phytotherapy in dermatology: back to the future. Dermatol Ther. 2003;16:106-113. https://doi.org/10.1046/j.1529-8019.2003.01618.x
  13. Deng S, May BH, Zhang AL, Lu C, Xue CC. Plant extracts for the topical management of psoriasis: a systematic review and meta-analysis. Br J Dermatol. 2013;169:769-782. https://doi.org/10.1111/bjd.12557
  14. Deng S, May BH, Zhang AL, Lu C, Xue CC. Topical herbal formulae in the ,anagement of psoriasis: systematic review with meta-analysis of clinical studies and investigation of the pharmacological actions of the main herbs. Phytother Res. 2014;28:480-497 https://doi.org/10.1002/ptr.5028
  15. Dhanabal SP, Priyanka Dwarampudi L, Muruganantham N, Vadivelan R. Evaluation of the antipsoriatic activity of Aloe vera leaf extract using a mouse tail model of psoriasis. Phytother Res. 2012;26:617-619. https://doi.org/10.1002/ptr.3589
  16. Ehsani AH, Ghaninejad H, Kiani A, Daneshpazhooh M, Hosseini SH, Noormohammadpoor P. Comparison of topical 8-methoxypsoralen and narrowband ultraviolet B with narrowband ultraviolet B alone in treatment-resistant sites in plaque-type psoriasis: a placebo-controlled study. Photodermatol Photoimmunol Photomed. 2011;27:294-296. https://doi.org/10.1111/j.1600-0781.2011.00615.x
  17. Ellis CN, Berberian B, Sulica VI, Dodd WA, Jarratt MT, Katz HI, Prawer S, Krueger G, Rex IH Jr, Wolf JE. A double-blind evaluation of topical capsaicin in pruritic psoriasis. J Am Acad Dermatol. 1993;29:438-442. https://doi.org/10.1016/0190-9622(93)70208-B
  18. Gelmini F, Beretta G, Anselmi C, Centini M, Magni P, Ruscica M, Cavalchini A, Maffei Facino R. GC-MS profiling of the phytochemical constituents of the oleoresin from Copaifera langsdorffii Desf. and a preliminary in vivo evaluation of its antipsoriatic effect. Int J Pharm. 2013;440:170-178. https://doi.org/10.1016/j.ijpharm.2012.08.021
  19. Gonul M, Cakmak SK, Gul U, Biyikli Z. What do patients with psoriasis think about the causes of their disease and use for psoriasis? TANG. 2012;2:e8.
  20. Grover JK, Yadav SP. Pharmacological actions and potential uses of Momordica charantia: a review. J Ethnopharmacol. 2004;93:123-132. https://doi.org/10.1016/j.jep.2004.03.035
  21. Gudjonsson JE, Aphale A, Grachtchouk M, Ding J, Nair RP, Wang T, Voorhees JJ, Dlugosz AA, Elder JT. Lack of evidence for activation of the hedgehog pathway in psoriasis. J Invest Dermatol. 2009;129:635-640. https://doi.org/10.1038/jid.2008.266
  22. Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013;15:195-218. https://doi.org/10.1208/s12248-012-9432-8
  23. Gupta SC, Kismali G, Aggarwal BB. Curcumin, a component of turmeric: from farm to pharmacy. Biofactors. 2013;39:2-13. https://doi.org/10.1002/biof.1079
  24. Heng MC, Song MK, Heng MK. Elevated phosphorylase kinase activity in psoriatic epidermis: correlation with increased phosphorylation and psoriatic activity. Br J Dermatol. 1994;130:298-306. https://doi.org/10.1111/j.1365-2133.1994.tb02924.x
  25. Heng MC, Song MK, Harker J, Heng MK. Drug-induced suppression of phosphorylase kinase activity correlates with resolution of psoriasis as assessed by clinical, histological and immunohistochemical parameters. Br J Dermatol. 2000;143:937-949. https://doi.org/10.1046/j.1365-2133.2000.03767.x
  26. Hovhannisyan A, Matz M, Gebhardt R. From teratogens to potential therapeutics: natural inhibitors of the Hedgehog signaling network come of age. Planta Med. 2009;75:1371-1380. https://doi.org/10.1055/s-0029-1185979
  27. Hönigsmann H, Schwarz T. Ultraviolet Therapy. In Dermatology. Bolognia JL, Jorizzo JL, Schaffer JV. eds. 3rd ed. (Philadelphia, USA: Mosby), pp.2219-2235, 2012.
  28. Hsieh WL, Lin YK, Tsai CN, Wang TM, Chen TY, Pang JH. Indirubin, an acting component of indigo naturalis, inhibits EGFR activation and EGF-induced CDC25B gene expression in epidermal keratinocytes. J Dermatol Sci. 2012;67:140-146. https://doi.org/10.1016/j.jdermsci.2012.05.008
  29. de Jager ME, van de Kerkhof PC, de Jong EM, Seyger MM. Dithranol therapy in childhood psoriasis: unjustifiably on the verge of falling into oblivion. Dermatology. 2010;220:329-332. https://doi.org/10.1159/000278241
  30. Jensen P. Use of alternative medicine by patients with atopic dermatitis and psoriasis. Acta Derm Venereol. 1990;70:421-424.
  31. van de Kerkhof PC, van der Valk PG, Swinkels OQ, Kucharekova M, de Rie MA, de Vries HJ, Damstra R, Oranje AP, de Waard-van der Spek FB, van Neer P, Lijnen RL, Kunkeler AC, van Hees C, Haertlein NG, Hol CW. A comparison of twice-daily calcipotriol ointment with oncedaily short-contact dithranol cream therapy: a randomized controlled trial of supervised treatment of psoriasis vulgaris in a day-care setting. Br J Dermatol. 2006;155:800-807. https://doi.org/10.1111/j.1365-2133.2006.07393.x
  32. Koo J, Arain S. Traditional Chinese medicine in dermatology. Clin Dermatol. 1999;17:21-27. https://doi.org/10.1016/S0738-081X(98)00067-4
  33. Liang CY, Lin TY, Lin YK. Successful treatment of pediatric nail psoriasis with periodic pustular eruption using topical indigo naturalis oil extract. Pediatr Dermatol. 2013;30:117-119. https://doi.org/10.1111/j.1525-1470.2012.01721.x
  34. Lin YK. Indigo naturalis oil extract drops in the treatment of moderate to severe nail psoriasis: a small case series. Arch Dermatol. 2011;147:627-629. https://doi.org/10.1001/archdermatol.2011.112
  35. Lin YK, Chang CJ, Chang YC, Wong WR, Chang SC, Pang JH. Clinical assessment of patients with recalcitrant psoriasis in a randomized, observer-blind, vehicle-controlled trial using indigo naturalis. Arch Dermatol. 2008;144:1457-1464.
  36. Lin YK, Leu YL, Yang SH, Chen HW, Wang CT, Pang JH. Anti-psoriatic effects of indigo naturalis on the proliferation and differentiation of keratinocytes with indirubin as the active component. J Dermatol Sci. 2009;54:168-174. https://doi.org/10.1016/j.jdermsci.2009.02.007
  37. Lin YK, See LC, Chang YC, Huang YH, Chen JL, Tsou TC, Leu YL, Shen YM. Treatment of psoriatic nails with indigo naturalis oil extract: a non-controlled pilot study. Dermatology. 2011;223:239-243. https://doi.org/10.1159/000333362
  38. Lin YK, Wong WR, Chang YC, Chang CJ, Tsay PK, Chang SC, Pang JH. The efficacy and safety of topically applied indigo naturalis ointment in patients with plaque-type psoriasis. Dermatology. 2007;214:155-161. https://doi.org/10.1159/000098576
  39. Lin YK, Wong WR, Su Pang JH. Successful treatment of recalcitrant psoriasis with Indigo naturalis ointment. Clin Exp Dermatol. 2007;32:99-100.
  40. Lin YK, Yen HR, Wong WR, Yang SH, Pang JH. Successful treatment of pediatric psoriasis with Indigo naturalis composite ointment. Pediatr Dermatol. 2006;23:507-510. https://doi.org/10.1111/j.1525-1470.2006.00295.x
  41. Markham T, Rogers S, Collins P. Narrowband UV-B (TL-01) phototherapy vs oral 8-methoxypsoralen psoralen-UV-A for the treatment of chronic plaque psoriasis. Arch Dermatol. 2003;139:325-328.
  42. McFerren MA. Useful plants of dermatology. VIII. The false hellebore (Veratrum californicum). J Am Acad Dermatol. 2006;54:718-720. https://doi.org/10.1016/j.jaad.2005.11.1075
  43. Menter A, Korman NJ, Elmets CA, Feldman SR, Gelfand JM, Gordon KB, Gottlieb A,Koo JY, Lebwohl M, Lim HW, Van Voorhees AS, Beutner KR, Bhushan R; American Academy of Dermatology. Guidelines of care for the management of psoriasis and psoriatic arthritis. Section 3. Guidelines of care for the management and treatment of psoriasis with topical therapies. J Am Acad Dermatol. 2009;60:643-659. https://doi.org/10.1016/j.jaad.2008.12.032
  44. Najafizadeh P, Hashemian F, Mansouri P, Farshi S, Surmaghi MS, Chalangari R. The evaluation of the clinical effect of topical St Johns wort (Hypericum perforatum L.) in plaque type psoriasis vulgaris: a pilot study. Australas J Dermatol. 2012;53:131-135. https://doi.org/10.1111/j.1440-0960.2012.00877.x
  45. Nayak BS, Raju SS, Chalapathi Rao AV. Wound healing activity of Persea americana (avocado) fruit: a preclinical study on rats. J Wound Care. 2008;17:123-126. https://doi.org/10.12968/jowc.2008.17.3.28670
  46. Pari L, Tewas D, Eckel J. Role of curcumin in health and disease. Arch Physiol Biochem. 2008;114:127-149. https://doi.org/10.1080/13813450802033958
  47. Paulsen E, Korsholm L, Brandrup F. A double-blind, placebocontrolled study of a commercial Aloe vera gel in the treatment of slight to moderate psoriasis vulgaris. J Eur Acad Dermatol Venereol. 2005;19:326-331. https://doi.org/10.1111/j.1468-3083.2004.01186.x
  48. Rahman M, Alam K, Ahmad MZ, Gupta G, Afzal M, Akhter S, Kazmi I, Jyoti, Ahmad FJ, Anwar F. Classical to current approach for treatment of psoriasis: a review. Endocr Metab Immune Disord Drug Targets. 2012;12:287-302. https://doi.org/10.2174/187153012802002901
  49. Reuter J, Merfort I, Schempp CM. Botanicals in dermatology: an evidence-based review. Am J Clin Dermatol. 2010;11:247-267.
  50. Reuter J, Wolfle U, Weckesser S, Schempp C. Which plant for which skin disease? Part 1: Atopic dermatitis, psoriasis, acne, condyloma and herpes simplex. J Dtsch Dermatol Ges. 2010;8:788-796.
  51. Sampson JH, Raman A, Karlsen G, Navsaria H, Leigh IM. In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins. Phytomedicine. 2001;8:230-235. https://doi.org/10.1078/0944-7113-00032
  52. Schon MP, Boehncke WH. Psoriasis. N Engl J Med. 2005;352:1899-1912. https://doi.org/10.1056/NEJMra041320
  53. Smith N, Shin DB, Brauer JA, Mao J, Gelfand JM. Use of complementary and alternative medicine among adults with skin disease: results from a national survey. J Am Acad Dermatol. 2009;60:419-425. https://doi.org/10.1016/j.jaad.2008.11.905
  54. Smith N, Weymann A, Tausk FA, Gelfand JM. Complementary and alternative medicine for psoriasis: a qualitative review of the clinical trial literature. J Am Acad Dermatol. 2009;61:841-856. https://doi.org/10.1016/j.jaad.2009.04.029
  55. Stucker M, Memmel U, Hoffmann M, Hartung J, Altmeyer P. Vitamin B(12) cream containing avocado oil in the therapy of plaque psoriasis. Dermatology. 2001;203:141-147. https://doi.org/10.1159/000051729
  56. Syed TA, Ahmad SA, Holt AH, Ahmad SA, Ahmad SH, Afzal M. Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo controlled, double-blind study. Trop Med Int Health. 1996;1:505-509. https://doi.org/10.1046/j.1365-3156.1996.d01-91.x
  57. Tas S, Avci O. Rapid clearance of psoriatic skin lesions induced by topical cyclopamine. A preliminary proof of concept study. Dermatology. 2004;209:126-131. https://doi.org/10.1159/000079596
  58. Thangapazham RL, Sharma A, Maheshwari RK. Beneficial role of curcumin in skin diseases. Adv Exp Med Biol. 2007;595:343-357. https://doi.org/10.1007/978-0-387-46401-5_15
  59. Traub M, Marshall K. Psoriasis--pathophysiology, conventional, and alternative approaches to treatment. Altern Med Rev. 2007;12:319-330.
  60. Tse TW. Use of common Chinese herbs in the treatment of psoriasis. Clin Exp Dermatol. 2003;28:469-475. https://doi.org/10.1046/j.1365-2230.2003.01322.x
  61. Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Br J Gen Pract. 1999;49:823-828.
  62. Yu CS. Study on HIF-1$\alpha$ Gene Translation in Psoriatic Epidermis with the Topical Treatment of Capsaicin Ointment. ISRN Pharm. 2011;2011:821874.
  63. Yuqi TT. Review of a treatment for psoriasis using herose, a botanical formula. J Dermatol. 2005;32:940-945. https://doi.org/10.1111/j.1346-8138.2005.tb00878.x

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