Journal of Acupuncture Research

  • 제32권4호
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  • Pages.119-131
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  • 2015
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  • 2586-288X(pISSN)
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  • 2586-2898(eISSN)
대한침구의학회 (Korean Acupuncture & Moxibustion Medicine Society)
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금은화, 연교 및 황련해독탕 약침이 아토피 피부염 유발 NC/Nga 생쥐에 미치는 영향

The Effects of Lonicerae Flos, Forsythiae Fluctus and Hwangryunhaedok Decoction Pharmacopuncture on Atopic Dermatitis in NC/Nga Mice

  • 유정석 (우석대학교 부속한방병원 침구의학과) ;
  • 김종욱 (우석대학교 부속한방병원 침구의학과) ;
  • 이창현 (우석대학교 해부학교실) ;
  • 이상룡 (우석대학교 경혈학교실) ;
  • 육태한 (우석대학교 부속한방병원 침구의학과)
  • Yu, Jung Suk (Department of Acupuncture & Moxibustion Medicine, Korean Medicine Hospital of Woosuk University) ;
  • Kim, Jong Uk (Department of Acupuncture & Moxibustion Medicine, Korean Medicine Hospital of Woosuk University) ;
  • Lee, Chang Hyun (Department of Anatomy, College of Korean Medicine, Woosuk University) ;
  • Lee, Sang Ryong (Department of Meridian & Acupoint, College of Korean Medicine, Woosuk University) ;
  • Yook, Tae Han (Department of Acupuncture & Moxibustion Medicine, Korean Medicine Hospital of Woosuk University)
  • 투고 : 2015.12.12
  • 심사 : 2015.12.15
  • 발행 : 2015.12.18
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초록

Objectives : Atopic dermatitis is a chronic inflammatory skin disease characterized by pruritic and erythematous skin lesions. The purpose of this study was to investigate the suppressive effects of Lonicerae Flos, Forsythiae Fluctus and Hwangryunhaedok Decoction Pharmacopuncture on the development of atopic dermatitis-like skin lesions in NC/Nga Mice. Methods : The Atopic Dermatitis was induced by biostir AD on the mice's back skin. Experimental groups were divided into three including LFP(Lonicerae Flos Pharmacopuncture, EtOH extract), FFP(Forsythiae Fluctus Pharmacopuncture, EtOH extract) and HHP(Hwangryunhaedok Decoction Pharmacopuncture, Hydrodistillation extract). Every second day, the mice of three groups were treated with $0.1m{\ell}$ of pharmacopuncture using a syringe at right and left acupoints ($BL_{13}$), alternatively. On the control group, normal saline was used instead of pharmacopuncture. Subsequently optical observation with a handscope, a clinical skin score, Tissue(general/immune) mast cell, Serum IgE level, Serum histamine level, and Serum lymphokine(IL-2, IL-4, $IFN-{\gamma}{\gamma}$) were measured. Results : FFP and HHP decreased the clinical skin score, the total cell number of mast cells, and the Serum total IgE level and Serum histamine level. In Serum lymphokine levels, all groups were decreased to the IL-4 level, LFP and FFP were increased to the IL-2 level, and LFP was increased to the $IFN-{\gamma}$ level. Conclusions : From the above results, Forsythiae Fluctus Pharmacopuncture (EtOH extract) and Hwangryunhaedok Decoction Pharmacopuncture (Hydrodistillation extract) exerted anti-allergic and anti-inflammatory effects, suggesting a promising agent for improving atopic dermatitis related symptoms.

키워드

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피인용 문헌

  1. A Natural Compound Mixture Containing Arctigenin, Hederagenin, and Baicalein Alleviates Atopic Dermatitis in Mice by Regulating HPA Axis and Immune Activity vol.2020, pp.None, 2020, https://doi.org/10.1155/2020/1970349