Asian-Australasian Journal of Animal Sciences

  • 제28권2호
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  • Pages.151-157
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  • 2015
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  • 1011-2367(pISSN)
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  • 1976-5517(eISSN)
아세아태평양축산학회 (Asian Australasian Association of Animal Production Societies)
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A Candidate Single Nucleotide Polymorphism in the 3' Untranslated Region of Stearoyl-CoA Desaturase Gene for Fatness Quality and the Gene Expression in Berkshire Pigs

  • Lim, Kyu-Sang (College of Life Sciences and Biotechnology, Korea University) ;
  • Kim, Jun-Mo (College of Life Sciences and Biotechnology, Korea University) ;
  • Lee, Eun-A (College of Life Sciences and Biotechnology, Korea University) ;
  • Choe, Jee-Hwan (College of Life Sciences and Biotechnology, Korea University) ;
  • Hong, Ki-Chang (College of Life Sciences and Biotechnology, Korea University)
  • 투고 : 2014.07.16
  • 심사 : 2014.09.30
  • 발행 : 2015.02.01
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초록

Fatness qualities in pigs measured by the amount of fat deposition and composition of fatty acids (FAs) in pork have considerable effect on current breeding goals. The stearoyl-CoA desaturase (SCD) gene plays a crucial role in the conversion of saturated FAs into monounsaturated FAs (MUFAs), and hence, is among the candidate genes responsible for pig fatness traits. Here, we identified a single nucleotide polymorphism (SNP, $c.^*2041T$ >C) in the 3' untranslated region by direct sequencing focused on coding and regulatory regions of porcine SCD. According to the association analysis using a hundred of Berkshire pigs, the SNP was significantly associated with FA composition (MUFAs and polyunsaturated FAs [PUFAs]), polyunsaturated to saturated (P:S) FA ratio, n-6:n-3 FA ratio, and extent of fat deposition such as intramuscular fat and marbling (p<0.05). In addition, the SNP showed a significant effect on the SCD mRNA expression levels (p = 0.041). Based on our results, we suggest that the SCD $c.^*2041T$ >C SNP plays a role in the gene regulation and affects the fatness qualities in Berkshire pigs.

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피인용 문헌

  1. Genome-Wide Association Study Singles Out SCD and LEPR as the Two Main Loci Influencing Intramuscular Fat Content and Fatty Acid Composition in Duroc Pigs vol.11, pp.3, 2016, https://doi.org/10.1371/journal.pone.0152496
  2. Genome-wide association study confirm major QTL for backfat fatty acid composition on SSC14 in Duroc pigs vol.18, pp.1, 2017, https://doi.org/10.1186/s12864-017-3752-0
  3. Genome-wide association studies reveal additional related loci for fatty acid composition in a Duroc pig multigenerational population vol.88, pp.10, 2017, https://doi.org/10.1111/asj.12793
  4. on the growth performance as well as meat quality of fattening pigs vol.89, pp.4, 2018, https://doi.org/10.1111/asj.12967
  5. The expression of the SCD1 gene and its correlation with fattening and carcass traits in sheep vol.59, pp.1, 2015, https://doi.org/10.5194/aab-59-37-2016
  6. Evaluation of SCD, ACACA and FASN Mutations: Effects on Pork Quality and Other Production Traits in Pigs Selected Based on RNA-Seq Results vol.10, pp.1, 2015, https://doi.org/10.3390/ani10010123