Asian-Australasian Journal of Animal Sciences

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
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Bovine Genome-wide Association Study for Genetic Elements to Resist the Infection of Foot-and-mouth Disease in the Field

  • Lee, Bo-Young (Department of Agricultural Biotechnology, Animal Biotechnology Major, and Research Institute for Agriculture and Life Sciences, Seoul National University) ;
  • Lee, Kwang-Nyeong (Foot-and-Mouth Disease Division, Animal and Plant Quarantine Agency) ;
  • Lee, Taeheon (Department of Agricultural Biotechnology, Animal Biotechnology Major, and Research Institute for Agriculture and Life Sciences, Seoul National University) ;
  • Park, Jong-Hyeon (Foot-and-Mouth Disease Division, Animal and Plant Quarantine Agency) ;
  • Kim, Su-Mi (Foot-and-Mouth Disease Division, Animal and Plant Quarantine Agency) ;
  • Lee, Hyang-Sim (Foot-and-Mouth Disease Division, Animal and Plant Quarantine Agency) ;
  • Chung, Dong-Su (Gangwon Veterinary Service Laboratory) ;
  • Shim, Hang-Sub (Gyeonggido Veterinary Service) ;
  • Lee, Hak-Kyo (Genomic Informatics Center, Hankyong National University) ;
  • Kim, Heebal (Department of Agricultural Biotechnology, Animal Biotechnology Major, and Research Institute for Agriculture and Life Sciences, Seoul National University)
  • Received : 2014.05.21
  • Accepted : 2014.08.21
  • Published : 2015.02.01
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Abstract

Foot-and-mouth disease (FMD) is a highly contagious disease affecting cloven-hoofed animals and causes severe economic loss and devastating effect on international trade of animal or animal products. Since FMD outbreaks have recently occurred in some Asian countries, it is important to understand the relationship between diverse immunogenomic structures of host animals and the immunity to foot-and-mouth disease virus (FMDV). We performed genome wide association study based on high-density bovine single nucleotide polymorphism (SNP) chip for identifying FMD resistant loci in Holstein cattle. Among 624532 SNP after quality control, we found that 11 SNPs on 3 chromosomes (chr17, 22, and 15) were significantly associated with the trait at the p.adjust <0.05 after PERMORY test. Most significantly associated SNPs were located on chromosome 17, around the genes Myosin XVIIIB and Seizure related 6 homolog (mouse)-like, which were associated with lung cancer. Based on the known function of the genes nearby the significant SNPs, the FMD resistant animals might have ability to improve their innate immune response to FMDV infection.

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References

  1. Bachrach, H. L. 1985. Foot-and-mouth disease and its antigens. Adv. Exp. Med. Biol. 185:27-46. https://doi.org/10.1007/978-1-4684-7974-4_2
  2. Belsham, G. J. 1993. Distinctive features of foot-and-mouth disease virus, a member of the picornavirus family; aspects of virus protein synthesis, protein processing and structure. Prog. Biophys. Mol. Biol. 60:241-260. https://doi.org/10.1016/0079-6107(93)90016-D
  3. Gerner, W., B. V. Carr, K. H. Wiesmuller, E. Pfaff, A. Saalmuller, and B. Charleston. 2007. Identification of a novel foot-andmouth disease virus specific T-cell epitope with immunodominant characteristics in cattle with MHC serotype A31. Vet. Res. 38:565-572. https://doi.org/10.1051/vetres:2007016
  4. Gorlov, I. P., P. Meyer, T. Liloglou, J. Myles, M. B. Boettger, A. Cassidy, L. Girard, J. D. Minna, R. Fischer, S. Duffy, M. R. Spitz, K. Haeussinger, S. Kammerer, C. Cantor, R. Dierkesmann, J. K. Field, and C. I. Amos. 2007. Seizure 6-like (SEZ6L) gene and risk for lung cancer. Cancer Res. 67:8406-8411. https://doi.org/10.1158/0008-5472.CAN-06-4784
  5. Grubman, M. J. and B. Baxt. 2004. Foot-and-mouth disease. Clin. Microbiol. Rev. 17:465-493. https://doi.org/10.1128/CMR.17.2.465-493.2004
  6. Guzman, E., G. Taylor, B. Charleston, M. A. Skinner, and S. A. Ellis. 2008. An MHC-restricted $CD8^{+}$ T-cell response is induced in cattle by foot-and-mouth disease virus (FMDV) infection and also following vaccination with inactivated FMDV. J. Gen. Virol. 89:667-675. https://doi.org/10.1099/vir.0.83417-0
  7. Haghparast, A., M. H. M. Wauben, M. C. Grosfeld-Stulemeyer, P. van Kooten, and E. J. Hensen. 2000. Selection of T-cell epitopes from foot-and-mouth disease virus reflects the binding affinity to different cattle MHC class II molecules. Immunogenetics 51:733-742. https://doi.org/10.1007/s002510000205
  8. Janeway, C., P. Travers, M. Walport, and M. Shlomchik. 2001. Immunobiology, 4 ed. Garland Science, New York, USA.
  9. Male, D. 2006. Mechanisms of innate imnmunity. In: Immunology (Eds. D. Male, J. Brostoff, and D. Roth), 7 ed. Elsevier Health Sciences, Philadelphia, PA, USA. pp. 127-144.
  10. Morerio, C., M. Acquila, A. Rapella, E. Tassano, C. Rosanda, and C. Panarello. 2006. Inversion (11)(p15q22) with NUP98-DDX10 fusion gene in pediatric acute myeloid leukemia. Cancer Genet. Cytogenet. 171:122-125. https://doi.org/10.1016/j.cancergencyto.2006.07.002
  11. Nakano, T., M. Tani, M. Nishioka, T. Kohno, A. Otsuka, S. Ohwada, and J. Yokota. 2005. Genetic and epigenetic alterations of the candidate tumor-suppressor gene MYO18B, on chromosome arm 22q, in colorectal cancer. Genes Chromosomes Cancer 43:162-171. https://doi.org/10.1002/gcc.20180
  12. Nakao, K., M. Nishino, K. Takeuchi, M. Iwata, A. Kawano, Y. Arai, and M. Ohki. 2000. Fusion of the nucleoporin gene, NUP98, and the putative RNA Helicase Gene, DZXX10, by Inversion 11 (p15q22) chromosome translocation in a patient with etoposide-related myelodysplastic syndrome. Intern. Med. 39:412-415. https://doi.org/10.2169/internalmedicine.39.412
  13. Nishioka, M., T. Kohno, M. Takahashi, T. Niki, T. Yamada, S. Sone, and J. Yokota. 2000. Identification of a 428-kb homozygously deleted region disrupting the SEZ6L gene at 22q12.1 in a lung cancer cell line. Oncogene 19:6251-6260. https://doi.org/10.1038/sj.onc.1204031
  14. Nishioka, M., T. Kohno, M. Tani, N. Yanaihara, Y. Tomizawa, A. Otsuka, S. Sasaki, K. Kobayashi, T. Niki, A. Maeshima, Y. Sekido, J. D. Minna, S. Sone, and J. Yokota. 2002. MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer. Proc. Natl. Acad. Sci. USA. 99:12269-12274. https://doi.org/10.1073/pnas.192445899
  15. Nishiyama, M., Y. Arai, Y. Tsunematsu, H. Kobayashi, K. Asami, M. Yabe, S. Kato, M. Oda, H. Eguchi, M. Ohki, and Y. Kaneko. 1999. 11p15 translocations involving the NUP98 gene in childhood therapy-related acute myeloid leukemia/myelodysplastic syndrome. Genes Chromosomes Cancer 26:215-220. https://doi.org/10.1002/(SICI)1098-2264(199911)26:3<215::AID-GCC5>3.0.CO;2-1
  16. Pahl, R. and H. Schafer. 2010. PERMORY: an LD-exploiting permutation test algorithm for powerful genome-wide association testing. Bioinformatics 26:2093-2100. https://doi.org/10.1093/bioinformatics/btq399
  17. Purcell, S., B. Neale, K. Todd-Brown, L. Thomas, M. A. R. Ferreira, D. Bender, J. Maller, P. Sklar, P. I. W. De Bakker, M. J. Daly, and P. C. Sham. 2007. PLINK: a tool set for wholegenome association and population-based linkage analyses. Am. J. Hum. Genet. 81:559-575. https://doi.org/10.1086/519795
  18. Sobrino, F., M. Saiz, M. A. Jimenez-Clavero, J. I. Nunez, M. F. Rosas, E. Baranowski, and V. Ley. 2001. Foot-and-mouth disease virus: a long known virus, but a current threat. Vet. Res. 32:1-30. https://doi.org/10.1051/vetres:2001106
  19. Summerfield, A., L. Guzylack-Piriou, L. Harwood, and K. C. McCullough. 2009. Innate immune responses against foot-andmouth disease virus: Current understanding and future directions. Vet. Immunol. Immunopathol. 128:205-210. https://doi.org/10.1016/j.vetimm.2008.10.296
  20. Tani, M., J. Ito, M. Nishioka, T. Kohno, K. Tachibana, M. Shiraishi, S. Takenoshita, and J. Yokota. 2004. Correlation between histone acetylation and expression of the MYO18B gene in human lung cancer cells. Genes Chromosomes Cancer 40:146-151. https://doi.org/10.1002/gcc.20027
  21. Yanaihara, N., M. Nishioka, T. Kohno, A. Otsuka, A. Okamoto, K. Ochiai, T. Tanaka, and J. Yokota. 2004. Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer. Int. J. Cancer 112:150-154. https://doi.org/10.1002/ijc.20339
  22. Yokota, J. and T. Kohno. 2004. Molecular footprints of human lung cancer progression. Cancer Sci. 95:197-204. https://doi.org/10.1111/j.1349-7006.2004.tb02203.x
  23. Yokota, J., M. Nishioka, M. Tani, and T. Kohno. 2003. Genetic alterations responsible for metastatic phenotypes of lung cancer cells. Clin. Exp. Metastasis 20:189-193. https://doi.org/10.1023/A:1022978932215
  24. Zhou, F., X. Zhang, H. van Dam, P. ten Dijke, H. Huang, and L. Zhang. 2012. Ubiquitin-specific protease 4 mitigates tolllike/interleukin-1 receptor signaling and regulates innate immune activation. J. Biol. Chem. 287:11002-11010. https://doi.org/10.1074/jbc.M111.328187

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