Pediatric Infection and Vaccine

The Korean Society of Pediatric Infectious Diseases (대한소아감염학회)
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Middle East Respiratory Syndrome Coronavirus Infection in Children

소아에서 중동호흡기증후군의 역학적 특징 및 임상 양상

  • Lee, Hyunju (Department of Pediatrics, Seoul National University Bundang Hospital) ;
  • Han, Mi Seon (Department of Pediatrics, Seoul National University Bundang Hospital)
  • 이현주 (분당서울대학교병원 소아청소년과) ;
  • 한미선 (분당서울대학교병원 소아청소년과)
  • Received : 2015.11.07
  • Accepted : 2015.11.10
  • Published : 2015.12.25
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Abstract

Since 2012, outbreaks of the Middle East respiratory coronavirus (MERS-CoV) have been reported, including the Republic of Korea. To date, most of the people infected with the virus are adults. Herein we describe the clinical characteristics of cases of MERS-CoV infection among children. As of October 29, 2015, MERS-CoV has caused 34 pediatric infections, which accounts for 2.1% of all cases. The median age was 13 years (range 9 months to 17 years) and where gender has been reported (n=33), 57.6% cases were male. About half of the patients were asymptomatic and the majority of the symptomatic patients had respiratory symptoms. In general, the clinical outcome in children was favorable. Among the four patients who died of progressive pneumonia, three had documented comorbidities. MERS-CoV infection in children has a lower incidence and mortality compared to adults.

중동호흡기증후군 코로나바이러스(Middle East respiratory coronavirus, MERS-CoV)로 인한 질환은 2012년부터 보고되었다. 현재까지 대부분의 질환은 성인에서 발생하였으며 소아에 대한 보고는 매우 부족한 실정이다. 그리하여 본 연구에서는 소아에서 MERS-CoV 감염증의 역학적 특성과 임상 양상을 분석하였다. 전세계적으로 MERS-CoV에 감염된 소아는 34명이었으며(2015년 10월 29일 기준), 이는 전체 환자의 2.1%를 차지하였다. 소아 환자들의 중앙 연령은 13세(범위, 9개월부터 17세까지)이었으며, 성별이 보고된 자료(n=33) 중 57.6%가 남자였다. 전체 환자 중에서 약 반은 무증상 감염이었으며, 대부분의 증상이 있는 환자는 호흡기 증상을 동반하였다. MERS-CoV에 감염된 환자들의 예후는 대부분 양호하였으나, 사망한 환자는 4명이었으며 이 중 3명은 기저 질환이 있었다. 전세계적으로 소아에서 발생한 MERS-CoV 감염에 대한 보고 자료를 분석한 결과 MERS-CoV 감염은 소아에서 발생이 낮고 성인에 비해 예후가 좋은 것으로 나타났다.

Keywords

References

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