Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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Drug-induced blood cell dyscrasia associated with phenobarbital administration in a dog

  • Jung, Han-Byeol (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Kang, Min-Hee (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Park, Hee-Myung (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
  • Received : 2015.10.31
  • Accepted : 2015.12.15
  • Published : 2015.12.31
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Abstract

A 13-year-old, spayed, female Chihuahua dog was referred for evaluation of fever, lethargy, and dyspnea. Hematologic evaluation revealed severe neutropenia, thrombocytopenia, and mild anemia. The dog had been undergoing phenobarbital therapy for the past 7 weeks because of generalized seizures due to meningoencephalomyelitis of unknown etiology. After ruling out other possible causes of cytopenias, a tentative diagnosis was made of drug-induced blood cell dyscrasia. The neutropenia and thrombocytopenia resolved after discontinuation of phenobarbital (8 days and 15 days after discontinuation, respectively). This is the first case report in Korea to demonstrate blood dyscrasia associated with idiosyncratic adverse effects of phenobarbital.

Keywords

References

  1. Benichou C, Solal Celigny P. Standardization of definitions and criteria for causality assessment of adverse drug reactions. Drug-induced blood cytopenias: report of an international consensus meeting. Nouv Rev Fr Hematol 1991, 33, 257-262.
  2. Gaskill CL, Miller LM, Mattoon JS, Hoffmann WE, Burton SA, Gelens HCJ, Ihle SL, Miller JB, Shaw DH, Cribb AE. Liver histopathology and liver and serum alanine aminotransferase and alkaline phosphatase activities in epileptic dogs receiving phenobarbital. Vet Pathol 2005, 42, 147-160. https://doi.org/10.1354/vp.42-2-147
  3. Greenwood RS. Adverse effects of antiepileptic drugs. Epilepsia 2000, 41, S42-52. https://doi.org/10.1111/j.1528-1157.2000.tb01523.x
  4. Hauptman JG, Walshaw R, Olivier NB. Evaluation of the sensitivity and specificity of diagnostic criteria for sepsis in dogs. Vet Surg 1997, 26, 393-397. https://doi.org/10.1111/j.1532-950X.1997.tb01699.x
  5. Jacobs G, Calvert C, Kaufman A. Neutropenia and thrombocytopenia in three dogs treated with anticonvulsants. J Am Vet Med Assoc 1998, 212, 681-684.
  6. Khoutorsky A, Bruchim Y. Transient leucopenia, thrombocytopenia and anaemia associated with severe acute phenobarbital intoxication in a dog. J Small Anim Pract 2008, 49, 367-369. https://doi.org/10.1111/j.1748-5827.2008.00564.x
  7. Maddison JE, Page SW. Adverse drug reactions. In: Maddison JE, Page SW, Church D (eds.). Small Animal Clinical Pharmacology. 2nd ed. pp. 41-52, Saunders, Philadelphia, 2008.
  8. Muller PB, Taboada J, Hosgood G, Partington BP, VanSteenhouse JL, Taylor HW, Wolfsheimer KJ. Effects of long-term phenobarbital treatment on the liver in dogs. J Vet Intern Med 2000, 14, 165-171. https://doi.org/10.1111/j.1939-1676.2000.tb02231.x
  9. Podell M. Antiepileptic drug therapy. Clin Tech Small Anim Pract 1998, 13, 185-192. https://doi.org/10.1016/S1096-2867(98)80040-6
  10. Vernau KM, LeCouteur RA, Maddison JE. Anticonvulsant drugs. In: Maddison JE, Page SW, Church D (eds.). Small Animal Clinical Pharmacology. 2nd ed. pp. 367-379, Saunders, Philadelphia, 2008.
  11. Verrotti A, Coppola G, Parisi P, Mohn A, Chiarelli F. Bone and calcium metabolism and antiepileptic drugs. Clin Neurol Neurosurg 2010, 112, 1-10. https://doi.org/10.1016/j.clineuro.2009.10.011
  12. Verrotti A, Scaparrotta A, Grosso S, Chiarelli F, Coppola G. Anticonvulsant drugs and hematological disease. Neurol Sci 2014, 35, 983-993. https://doi.org/10.1007/s10072-014-1701-0
  13. Weiss DJ. Bone marrow necrosis in dogs: 34 cases (1996-2004). J Am Vet Med Assoc 2005, 227, 263-267. https://doi.org/10.2460/javma.2005.227.263
  14. Weiss DJ. Drug-associated blood cell dyscrasias. Compend Contin Educ Vet 2012, 34, E2.
  15. Zaccara G, Franciotta D, Perucca E. Idiosyncratic adverse reactions to antiepileptic drugs. Epilepsia 2007, 48, 1223-1244. https://doi.org/10.1111/j.1528-1167.2007.01041.x

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  1. Bone marrow, blood, and clinical findings in dogs treated with phenobarbital vol.50, pp.1, 2015, https://doi.org/10.1111/vcp.13013