Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
권호 표지
DOI QR코드

DOI QR Code

Primary Intracranial Leptomeningeal Melanomatosis

  • Kim, Do-Hyoung (Department of Neurosurgery, Ilsan Paik Hospital, College of Medicine, Inje University) ;
  • Choi, Chan-Young (Department of Neurosurgery, Ilsan Paik Hospital, College of Medicine, Inje University) ;
  • Lee, Chae-Heuck (Department of Neurosurgery, Ilsan Paik Hospital, College of Medicine, Inje University) ;
  • Joo, Mee (Department of Pathology, Ilsan Paik Hospital, College of Medicine, Inje University)
  • Received : 2014.09.09
  • Accepted : 2015.02.02
  • Published : 2015.12.28
Download PDF
⟨ Previous Next ⟩

Abstract

Primary intracranial malignant melanoma is a very rare and highly aggressive tumor with poor prognosis. A 66-year-old female patient presented a headache that had been slowly progressing for several months. A large benign pigmented skin lesion was found on her back. A brain MRI showed multiple linear signal changes with branching pattern and strong enhancement in the temporal lobe. The cytological and immunohiostochemical cerebrospinal fluid examination confirmed malignant melanoma. A biopsy confirmed that the pigmented skin lesion on the back and the conjunctiva were benign nevi. We report a case of primary intracranial malignant melanoma and review relevant literatures.

Keywords

References

  1. Gempt J, Buchmann N, Grams AE, Zoubaa S, Schlegel J, Meyer B, et al. : Black brain : transformation of a melanocytoma with diffuse melanocytosis into a primary cerebral melanoma. J Neurooncol 102 : 323-328, 2011 https://doi.org/10.1007/s11060-010-0311-9
  2. Greco Crasto S, Soffietti R, Bradac GB, Boldorini R : Primitive cerebral melanoma : case report and review of the literature. Surg Neurol 55 : 163-168; discussion 168, 2001 https://doi.org/10.1016/S0090-3019(01)00348-2
  3. Hayward RD : Malignant melanoma and the central nervous system. A guide for classification based on the clinical findings. J Neurol Neurosurg Psychiatry 39 : 526-530, 1976 https://doi.org/10.1136/jnnp.39.6.526
  4. Ibanez J, Weil B, Ayala A, Jimenez A, Acedo C, Rodrigo I : Meningeal melanocytoma : case report and review of the literature. Histopathology 30 : 576-581, 1997 https://doi.org/10.1046/j.1365-2559.1997.5660798.x
  5. Jaiswal S, Vij M, Tungria A, Jaiswal AK, Srivastava AK, Behari S : Primary melanocytic tumors of the central nervous system : a neuroradiological and clinicopathological study of five cases and brief review of literature. Neurol India 59 : 413-419, 2011 https://doi.org/10.4103/0028-3886.82758
  6. Jellinger K, Chou P, Paulus W : Melanocytic lesions in Kleihues P, Cavanee WK (ed) : Pathology and Genetics of Tumours of the Nervous system. Lyon : IARC Press, 2000
  7. Lee CJ, Rhee DY, Heo W, Park HS : Primary leptomeningeal malignant melanoma. J Korean Neurosurg Soc 36 : 425-427, 2004
  8. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, et al. : The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114 : 97-109, 2007 https://doi.org/10.1007/s00401-007-0243-4
  9. Piedra MP, Scheithauer BW, Driscoll CL, Link MJ : Primary melanocytic tumor of the cerebellopontine angle mimicking a vestibular schwannoma : case report. Neurosurgery 59 : E206; discussion E206, 2006 https://doi.org/10.1227/01.NEU.0000219236.48886.44
  10. Pirini MG, Mascalchi M, Salvi F, Tassinari CA, Zanella L, Bacchini P, et al. : Primary diffuse meningeal melanomatosis : radiologic-pathologic correlation. AJNR Am J Neuroradiol 24 : 115-118, 2003
  11. Roser F, Nakamura M, Brandis A, Hans V, Vorkapic P, Samii M : Transition from meningeal melanocytoma to primary cerebral melanoma. Case report. J Neurosurg 101 : 528-531, 2004 https://doi.org/10.3171/jns.2004.101.3.0528
  12. Shah I, Imran M, Akram R, Rafat S, Zia K, Emaduddin M : Primary intracranial malignant melanoma. J Coll Physicians Surg Pak 23 : 157-159, 2013

Cited by

  1. Primary cerebral malignant melanoma in insular region with extracranial metastasis: case report and review literature vol.14, pp.None, 2016, https://doi.org/10.1186/s12957-016-0965-7
  2. Primary central nervous system malignant melanoma with leptomeningeal melanomatosis: a case report and review of the literature vol.41, pp.1, 2015, https://doi.org/10.1007/s10143-017-0914-0
  3. Two cases of primary leptomeningeal melanomatosis mimicking subacute meningitis vol.31, pp.1, 2015, https://doi.org/10.1177/1971400917708581
  4. Melanoma of the central nervous system: A report of three cases vol.64, pp.3, 2015, https://doi.org/10.4103/ijpm.ijpm_642_20
  5. Diagnosis of meningeal melanomatosis in a dog using magnetic resonance imaging and cerebrospinal fluid findings vol.83, pp.1, 2015, https://doi.org/10.1292/jvms.20-0556