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Studies on Osmotically Driven Drug Infusion Pump Under the Change in Body-Simulating Environment

인체 내부 환경 변화 모사에 따른 삼투압 기반 약물주입펌프의 기능 평가 연구

  • Yoon, Chul Whan (Chungdam High School) ;
  • Ahn, Jae Hong (Chungdam High School) ;
  • Park, Doh (Chungdam High School) ;
  • Lee, Jae Yeon (Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University) ;
  • Park, Chun Gwon (Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University) ;
  • Park, Min (Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University) ;
  • Choy, Young Bin (Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University)
  • 윤철환 (청담고등학교) ;
  • 안재홍 (청담고등학교) ;
  • 박도 (청담고등학교) ;
  • 이재연 (서울대학교 바이오엔지니어링협동과정) ;
  • 박천권 (서울대학교 의학연구원 의용생체공학연구소) ;
  • 박민 (서울대학교 바이오엔지니어링협동과정) ;
  • 최영빈 (서울대학교 바이오엔지니어링협동과정)
  • Received : 2015.11.26
  • Accepted : 2015.12.09
  • Published : 2015.12.31

Abstract

Various types of implantable drug delivery devices have attracted significant attention for several decades to improve drug bioavailability and reduce side effects, thus enhancing therapeutic efficacy and patients' compliance. However, when implanted into the body, the devices may be influenced by the changes in physiological condition, such as temperature, pH or ionic concentration. Thus, the drug release rates could be also altered concurrently. Therefore, in this work, we employed an implantable ALZET$^{(R)}$ Osmotic Pump, which has been widely used to locally deliver various therapeutic agents and examined the effect of pH, temperature and ionic concentration on its drug release rate. For this, we performed in vitro cell tests to simulate the condition of local tissues influenced by the altered drug release rates, where we used diclofenac sodium as a model drug.

Acknowledgement

Supported by : 보건복지가족부

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