대한의용생체공학회:의공학회지 (Journal of Biomedical Engineering Research)

  • 제36권6호
  • /
  • Pages.291-295
  • /
  • 2015
  • /
  • 1229-0807(pISSN)
  • /
  • 2288-9396(eISSN)
대한의용생체공학회 (The Korean Society of Medical and Biological Engineering)
권호 표지
DOI QR코드

DOI QR Code

인체 내부 환경 변화 모사에 따른 삼투압 기반 약물주입펌프의 기능 평가 연구

Studies on Osmotically Driven Drug Infusion Pump Under the Change in Body-Simulating Environment

  • 윤철환 (청담고등학교) ;
  • 안재홍 (청담고등학교) ;
  • 박도 (청담고등학교) ;
  • 이재연 (서울대학교 바이오엔지니어링협동과정) ;
  • 박천권 (서울대학교 의학연구원 의용생체공학연구소) ;
  • 박민 (서울대학교 바이오엔지니어링협동과정) ;
  • 최영빈 (서울대학교 바이오엔지니어링협동과정)
  • Yoon, Chul Whan (Chungdam High School) ;
  • Ahn, Jae Hong (Chungdam High School) ;
  • Park, Doh (Chungdam High School) ;
  • Lee, Jae Yeon (Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University) ;
  • Park, Chun Gwon (Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University) ;
  • Park, Min (Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University) ;
  • Choy, Young Bin (Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University)
  • 투고 : 2015.11.26
  • 심사 : 2015.12.09
  • 발행 : 2015.12.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Various types of implantable drug delivery devices have attracted significant attention for several decades to improve drug bioavailability and reduce side effects, thus enhancing therapeutic efficacy and patients' compliance. However, when implanted into the body, the devices may be influenced by the changes in physiological condition, such as temperature, pH or ionic concentration. Thus, the drug release rates could be also altered concurrently. Therefore, in this work, we employed an implantable ALZET$^{(R)}$ Osmotic Pump, which has been widely used to locally deliver various therapeutic agents and examined the effect of pH, temperature and ionic concentration on its drug release rate. For this, we performed in vitro cell tests to simulate the condition of local tissues influenced by the altered drug release rates, where we used diclofenac sodium as a model drug.

키워드

참고문헌

  1. L. Allen, and H.C. Ansel, Ansel's pharmaceutical dosage forms and drug delivery systems, Philadelphia, United states of America: Lippincott Williams & Wilkins, 2013, pp. 832.
  2. K.E. Uhrich, S.M. Cannizzaro, R.S. Langer, and K.M. Shakesheff, "Polymeric systems for controlled drug release", Chem Rev, vol. 99, no. 11, pp. 3181-3198. 1999. https://doi.org/10.1021/cr940351u
  3. T.M. Allen, and P.R. Cullis, "Drug delivery systems: entering the mainstream", Science, vol. 303, no. 5665, pp. 1818-1822. 2004. https://doi.org/10.1126/science.1095833
  4. A.C. Richards Grayson, I.S. Choi, B.M. Tyler, P.P. Wang, H. Brem, M.J. Cima, et al., "Multi-pulse drug delivery from a resorbable polymeric microchip device", Nat Mater, vol. 2, no. 11, pp. 767-772. 2003. https://doi.org/10.1038/nmat998
  5. D.V. McAllister, M.G. Allen, and M.R. Prausnitz, "Microfabricated microneedles for gene and drug delivery", Annu Rev Biomed Eng, vol. 2, pp. 289-313. 2000. https://doi.org/10.1146/annurev.bioeng.2.1.289
  6. S.S. Davis, and L. Illum, "Polymeric Microspheres as Drug Carriers", Biomaterials, vol. 9, no. 1, pp. 111-115. 1988. https://doi.org/10.1016/0142-9612(88)90081-6
  7. A. Kumari, S.K. Yadav, and S.C. Yadav, "Biodegradable polymeric nanoparticles based drug delivery systems", Colloids Surf, B, vol. 75, no. 1, pp. 1-18. 2010. https://doi.org/10.1016/j.colsurfb.2009.09.001
  8. S.D. Allison, "Analysis of initial burst in PLGA microparticles", Expert Opin Drug Delivery, vol. 5, no. 6, pp. 615-628. 2008. https://doi.org/10.1517/17425247.5.6.615
  9. Y. Yeo, and K.N. Park, "Control of encapsulation efficiency and initial burst in polymeric microparticle systems", Arch Pharmacal Res, vol. 27, no. 1, pp. 1-12. 2004. https://doi.org/10.1007/BF02980037
  10. R.K. Verma, S. Arora, and S. Garg, "Osmotic pumps in drug delivery", Crit Rev Ther Drug Carrier Syst, vol. 21, no. 6, pp. 477-520. 2004. https://doi.org/10.1615/CritRevTherDrugCarrierSyst.v21.i6.20
  11. P. Cuevas, J. Burgos, and A. Baird, "Basic fibroblast growth factor (FGF) promotes cartilage repair in vivo", Biochem Biophys Res Commun, vol. 156, no. 2, pp. 611-618. 1988. https://doi.org/10.1016/S0006-291X(88)80887-8
  12. L. Diaz-Rodriguez, O. Garcia-Martinez, M.A. Morales, L. Rodriguez-Perez, B. Rubio-Ruiz, and C. Ruiz, "Effects of indomethacin, nimesulide, and diclofenac on human MG-63 osteosarcoma cell line", Biol Res Nurs, vol. 14, no. 1, pp. 98-107. 2012. https://doi.org/10.1177/1099800411398933
  13. A. Lardner, "The effects of extracellular pH on immune function", J Leukoc Biol, vol. 69, no. 4, pp. 522-530. 2001.
  14. E. Song, H. Jung, H. Lee, J. Kim, H. Kim, and Y. Lee, "The Production of protein-loaded poly (lactide-co-glycolide) microparticles using supercritical carbon dioxide", Clean Technol, vol. 12, no. 2, pp. 53-61. 2006.
  15. G. Healing, and D. Smith, Handbook of pre-clinical continuous intravenous infusion, London, United Kingdom: Taylor & Francis, 2000, pp. 265-281.