Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Anti-Inflammatory Effect of Violapyrones B and C from a Marine-derived Streptomyces sp.

  • Lee, Hwa-Sun (Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology) ;
  • An, Bong-Jeun (Department of Cosmeceutical Science, Dague Haany University) ;
  • Kim, Hyeon Jeong (Department of Cosmeceutical Science, Dague Haany University) ;
  • Cho, Yong Hun (Department of Cosmeceutical Science, Dague Haany University) ;
  • Kim, Dong In (Department of Cosmeceutical Science, Dague Haany University) ;
  • Jang, Jae Yoon (Department of Cosmeceutical Science, Dague Haany University) ;
  • Kwak, Jae Hoon (Department of Cosmeceutical Science, Dague Haany University) ;
  • Lee, Hyi-Seung (Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology) ;
  • Lee, Yeon-Ju (Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology) ;
  • Lee, Jong Seok (Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology) ;
  • Shin, Hee Jae (Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology)
  • Received : 2015.07.30
  • Accepted : 2015.09.30
  • Published : 2015.12.31
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Abstract

Recently, we reported violapyrones B, C, H and I, unusual 3, 4, 6-trisubstituted ${\alpha}-pyrones$ derivatives, from the culture broth of the marine Streptomyces sp. 112CH148. In previous studies, violapyrones have been shown to have antibacterial and antitumor activities. However, the anti-inflammatory effect of violapyrones has not been reported yet. As part of our ongoing study for the discovery of bioactive metabolites from marine microorganisms, we found that violapyrones also have anti-inflammatory activity. In this study, we investigated the effect of violapyrones on LPS-induced inflammatory responses in vitro. Violapyrones B and C did not affect the viability of RAW 264.7 cells at concentrations up to $25{\mu}M$. However, violapyrones B and C inhibited the production of NO compared to the LPS-induced control. In addition, violapyrones B and C down-regulated the expression of iNOS protein in LPS-stimulated RAW 264.7 cells. To the best of our knowledge, this is the first report on the anti-inflammatory activity of violapyrones B and C.

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