Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Salternamide E from a Saltern-derived Marine Actinomycete Streptomyces sp.

  • Kim, Seong-Hwan (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Shin, Yoonho (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Lee, Sang Kook (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Shin, Jongheon (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Oh, Dong-Chan (Natural Products Research Institute, College of Pharmacy, Seoul National University)
  • Received : 2015.07.18
  • Accepted : 2015.08.07
  • Published : 2015.12.31
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Abstract

Comprehensive chemical analysis of extracts and fractions of marine actinomycete strains led to the discovery of a new minor secondary metabolite, salternamide E (1), from a saltern-derived halophilic Streptomyces strain. The planar structure of salternamide E (1) was elucidated by a combinational analysis of spectroscopic data including NMR, MS, UV, and IR. The absolute configuration of salternamide E (1) was determined by circular dichroism spectroscopic analysis. Salternamide E displayed weak cytotoxicity against various human carcinoma cell lines.

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References

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