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Epi-Leptosphaerin: A New L-Isoascorbic Acid Derivative from Marine Sponges

  • Kulkarni, Roshan R. (College of Pharmacy, Chungnam National University) ;
  • Jo, A Reum (College of Pharmacy, Chungnam National University) ;
  • Kim, Young Ho (College of Pharmacy, Chungnam National University) ;
  • Na, MinKyun (College of Pharmacy, Chungnam National University)
  • Received : 2015.07.12
  • Accepted : 2015.09.30
  • Published : 2015.12.31

Abstract

A new L-isoascorbic acid derivative epi-leptosphaerin (1) and two known compounds leptosphaerin (2), and verongamine (3) were isolated from sponges of the orders Verongida and Thorectidae. Compounds 1 and 2 are most likely of sponge-associated fungal origin. In the present study, isolated compounds were investigated for their inhibition of soluble epoxide hydrolase (sEH), which is considered a promising target for the management of pain, inflammation, and comorbidities associated with diabetes. Compound 3, verongamine, displayed weak inhibitory activity against sEH with an $IC_{50}$ value $51.5{\pm}1.0{\mu}M$.

Keywords

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Cited by

  1. Marine natural products vol.34, pp.3, 2015, https://doi.org/10.1039/c6np00124f