Journal of Korean Society of Occupational and Environmental Hygiene (한국산업보건학회지)

Korean Industrial Hygiene Association (한국산업보건학회)
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Evaluation of Biodurability of Korean Chrysotile withen The Lung of Rats

한국산 백석면의 랫드의 폐 내 변화 연구

  • Chung, Yong Hyun (Toxicity Research Team, Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) ;
  • Han, Jeong Hee (Toxicity Research Team, Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency)
  • 정용현 (산업안전보건연구원 독성연구팀) ;
  • 한정희 (산업안전보건연구원 독성연구팀)
  • Received : 2014.11.11
  • Accepted : 2015.01.26
  • Published : 2015.03.31
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Abstract

Objectives: To evaluate the biodurability of Korean Chrysotile(KC), the changes in fibers numbers and changes in the element composition of fibers from the lung of Sprague-Dawley rats instilled KC(average size $4.74{\mu}m$, $59,043{\times}10^6$ fibers/mg) was estimated. Methods: Rats were administered 1 mg KC(low group) or 2 mg KC(high group) by a single intratracheal instillation. At each time point(5 days, 5 weeks, 10 weeks), the numbers of KC fibers and the changes of element composition(atomic %) of KC fibers from the lung of the rats were analyzed with transmission electron microscope equipped with energy dispersive X-ray spectrometer. Results: Over time, the number of fibers within the lungs of animals were reduced. The average length of the low and high group is significantly reduced from 5 days after administration. Over time, the fiber ratio of at least $5{\mu}m$ remaining in the lung tissue of the low concentration group was up but the high group was reduced. From day 5 after administration, the composition ratio(Mg) was significantly decreased in all groups. Conclusions: Size and composition of Korean Chrysotile in the lung tissue of rats was changed from 5 days.

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References

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