Preventive Nutrition and Food Science

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Anti-Fatigue Effects of Fermented Rhodiola rosea Extract in Mice

  • Received : 2014.11.07
  • Accepted : 2015.02.24
  • Published : 2015.03.31
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Abstract

Rhodiola rosea is a perennial plant which grows in the alpine regions of Europe and Asia. Although the protective effects of R. rosea extract from fatigue due to exercise stress have been reported, studies on fermented R. rosea extract remain insufficient to date. Therefore, this study was conducted to examine the protective effects of fermented R. rosea extract against fatigue and exercise stress. As a result, fermented R. rosea extract was found to significantly increase swimming time, hepatic superoxide dismutase content, and serum lactate dehydrogenase in mice, while decreasing serum blood urea nitrogen content compared to R. rosea extract. Given the above results, it is considered that fermented R. rosea extract effectively protects against fatigue caused by strenuous exercise.

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References

  1. Bassuk SS, Manson JE. 2005. Epidemiological evidence for the role of physical activity in reducing risk of type 2 diabetes and cardiovascular disease. J Appl Physiol 99: 1193-1204. https://doi.org/10.1152/japplphysiol.00160.2005
  2. Roberts CK, Barnard RJ. 2005. Effects of exercise and diet on chronic disease. J Appl Physiol 98: 3-30. https://doi.org/10.1152/japplphysiol.00852.2004
  3. Jenkins RR. 1993. Excercise, oxidative stress, and antioxidants. Int J Sport Nutr 3: 356-375. https://doi.org/10.1123/ijsn.3.4.356
  4. Hyun KY. 2009. An association of changed levels of inflammatory markers with hematological factors during one-time aerobic exercise in twenty-aged young men. J Life Sci 19: 1658-1665. https://doi.org/10.5352/JLS.2009.19.11.1658
  5. Moxnes JF, Sandbakk O. 2012. The kinetics of lactate production and removal during whole-body exercise. Theor Biol Med Model 9: 7. https://doi.org/10.1186/1742-4682-9-7
  6. Chan SW. 2012. Panax ginseng, Rhodiola rosea and Schisandra chinensis. Int J Food Sci Nutr 63: 75-81. https://doi.org/10.3109/09637486.2011.627840
  7. Bae SJ. 2005. Anticarcinogenic and antioxidant effects of Rhdiola sachalinensis. J Korean Soc Food Sci Nutr 34: 1302-1307. https://doi.org/10.3746/jkfn.2005.34.9.1302
  8. Lee EJ, Im JS, Park CK, Jeon BS, Kyung JS. 2005. Anti-hepatotoxic activity of Rhodiola sachalinensis roots. Food Industry and Nutrition 10(3): 37-42.
  9. Park KU, Yoon JH, Kim JY, Jeong CH, Park CK, Song WS, Seo KI. 2005. Biological activity of the fractions extracted from Rhodiola dumulosa. Korean J Food Preserv 12: 496-500.
  10. Li HB, Ge YK, Zheng XX, Zhang L. 2008. Salidroside stimulated glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase. Eur J Pharmacol 588: 165-169. https://doi.org/10.1016/j.ejphar.2008.04.036
  11. Ugliano M, Bartowsky EJ, McCarthy J, Moio L, Henschke PA. 2006. Hydrolysis and transformation of grape glycosidically bound volatile compounds during fermentation with three Saccharomyces yeast strains. J Agric Food Chem 54: 6322-6331. https://doi.org/10.1021/jf0607718
  12. Ryu SH, Kim SY, Jung HS, Sohn NW, Sohn YJ. 2008. Effects of Rhodiola rosea on anti-fatigue and hypothalamic IEGs expressions of forced swimming rats. Kor J Herbology 23: 9-19.
  13. Jung HS, Kim EY, Shim ES, Lee HS, Moon EJ, Jin ZH. 2008. Effects of Rhodiola rosea (KH101) on anti-fatigue in forced swimming rats. Korean J Orient Int Med 29: 922-938.
  14. Lee FT, Kuo TY, Liou SY, Chien CT. 2009. Chronic Rhodiola rosea extract supplementation enforces exhaustive swimming tolerance. Am J Chin Med 37: 557-572. https://doi.org/10.1142/S0192415X09007053
  15. Yang HJ, Weon JB, Lee BH, Ma CJ. 2011. The alteration of components in the fermented Hwangryunhaedok-tang and its neuroprotective activity. Pharmacogn Mag 7: 207-212. https://doi.org/10.4103/0973-1296.84234
  16. Huang SC, Lee FT, Kuo TY, Yang JH, Chien CT. 2009. Attenuation of long-term Rhodiola rosea supplementation on exhaustive swimming-evoked oxidative stress in the rat. Chin J Physiol 52: 316-324. https://doi.org/10.4077/CJP.2009.AMH029
  17. Garcia-Padial M, Martinez-Oharriz MC, Navarro-Blasco I, Zornoza A. 2013. The role of cyclodextrins in ORAC-fluorescence assays. Antioxidant capacity of tyrosol and caffeic acid with hydroxypropyl-${\beta}$-cyclodextrin. J Agric Food Chem 61: 12260-12264. https://doi.org/10.1021/jf403265b
  18. Djordjevic VB. 2004. Free radicals in cell biology. Int Rev Cytol 237: 57-89. https://doi.org/10.1016/S0074-7696(04)37002-6
  19. Irshad M, Chaudhuri PS. 2002. Oxidant-antioxidant system: role and significance in human body. Indian J Exp Biol 40: 1233-1239.
  20. Urso ML, Clarkson PM. 2003. Oxidative stress, exercise, and antioxidant supplementation. Toxicology 15: 41-54.
  21. Huang WC, Chiu WC, Chuang HL, Tang DW, Lee ZM, Wei L, Chen FA, Huang CC. 2015. Effect of curcumin supplementation on physiological fatigue and physical performance in mice. Nutrients 7: 905-921. https://doi.org/10.3390/nu7020905
  22. Liu J, Du C, Wang Y, Yu Z. 2015. Anti-fatigue activities of polysaccharides extracted from Hericium erinaceus. Exp Ther Med 9: 483-487. https://doi.org/10.3892/etm.2014.2139
  23. Anand T, Phani Kumar G, Pandareesh MD, Swamy MS, Khanum F, Bawa AS. 2012. Effect of bacoside extract from Bacopa monniera on physical fatigue induced by forced swimming. Phytother Res 26: 587-593. https://doi.org/10.1002/ptr.3611
  24. Gibson H, Edwards RH. 1985. Muscular exercise and fatigue. Sports Med 2: 120-132. https://doi.org/10.2165/00007256-198502020-00004
  25. Chen YS, Liou HC, Chan CF. 2013. Tyrosinase inhibitory effect and antioxidative activities of fermented and ethanol extracts of Rhodiola rosea and Lonicera japonica. Sci World J 2013: 612739.

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