Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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A Malignant Transformation of a Spinal Epidural Mass from Ganglioneuroblastoma to Neuroblastoma

  • Akcakaya, Mehmet Osman (Department of Neurosurgery, School of Medicine, Istanbul University) ;
  • Bilgic, Bilge (Department of Pathology, School of Medicine, Istanbul University) ;
  • Aras, Yavuz (Department of Neurosurgery, School of Medicine, Istanbul University) ;
  • Izgi, Nail (Department of Neurosurgery, School of Medicine, Istanbul University)
  • Received : 2013.11.26
  • Accepted : 2014.05.14
  • Published : 2015.03.28
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Abstract

Ganglioneuromas are benign tumors. Surgical excision is the treatment of choice with very good prognosis. However, neuroblastomatous malignant transformation of ganglioneuromas was previously reported. We report a patient with spinal neuroblastoma recurrent from a ganglioneuroblastoma after disease free survival of 13 years. This is one of the rare examples of spinal neuroblastoma and to our knowledge the second case report with malignant transformation from a ganglioneuroblastoma or a ganglioneuroma. The present case is the only report in the literature with further genetic investigations.

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References

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