DOI QR코드

DOI QR Code

A review of the regenerative endodontic treatment procedure

  • Lee, Bin-Na (Department of Conservative Dentistry, School of Dentistry, Dental Science Research Institute, Chonnam National University) ;
  • Moon, Jong-Wook (School of Dentistry, Chonnam National University) ;
  • Chang, Hoon-Sang (Department of Conservative Dentistry, School of Dentistry, Dental Science Research Institute, Chonnam National University) ;
  • Hwang, In-Nam (Department of Conservative Dentistry, School of Dentistry, Dental Science Research Institute, Chonnam National University) ;
  • Oh, Won-Mann (Department of Conservative Dentistry, School of Dentistry, Dental Science Research Institute, Chonnam National University) ;
  • Hwang, Yun-Chan (Department of Conservative Dentistry, School of Dentistry, Dental Science Research Institute, Chonnam National University)
  • 투고 : 2014.01.07
  • 심사 : 2015.01.29
  • 발행 : 2015.08.31

초록

Traditionally, apexification has been used to treat immature permanent teeth that have lost pulp vitality. This technique promotes the formation of an apical barrier to close the open apex so that the filling materials can be confined to the root canal. Because tissue regeneration cannot be achieved with apexification, a new technique called regenerative endodontic treatment was presented recently to treat immature permanent teeth. Regenerative endodontic treatment is a treatment procedure designed to replace damaged pulp tissue with viable tissue which restores the normal function of the pulp-dentin structure. After regenerative endodontic treatment, continued root development and hard tissue deposition on the dentinal wall can occur under ideal circumstances. However, it is difficult to predict the result of regenerative endodontic treatment. Therefore, the purpose of this study was to summarize multiple factors effects on the result of regenerative endodontic treatment in order to achieve more predictable results. In this study, we investigated the features of regenerative endodontic treatment in comparison with those of other pulp treatment procedures and analyzed the factors that have an effect on regenerative endodontic treatment.

키워드

참고문헌

  1. Rafter M. Apexification: a review. Dent Traumatol 2005;21:1-8. https://doi.org/10.1111/j.1600-9657.2004.00284.x
  2. Huang GJ. Apexification: the beginning of its end. Int Endod J 2009;42:855-866. https://doi.org/10.1111/j.1365-2591.2009.01577.x
  3. Banchs F, Trope M. Revascularization of immature permanent teeth with apical periodontitis: new treatment protocol? J Endod 2004;30:196-200. https://doi.org/10.1097/00004770-200404000-00003
  4. Huang GT, Sonoyama W, Liu Y, Liu H, Wang S, Shi S. The hidden treasure in apical papilla: the potential role in pulp/dentin regeneration and bioroot engineering. J Endod 2008;34:645-651. https://doi.org/10.1016/j.joen.2008.03.001
  5. Shah N, Logani A, Bhaskar U, Aggarwal V. Efficacy of revascularization to induce apexification/apexogensis in infected, nonvital, immature teeth: a pilot clinical study. J Endod 2008;34:919-925. https://doi.org/10.1016/j.joen.2008.05.001
  6. Shin SY, Albert JS, Mortman RE. One step pulp revascularization treatment of an immature permanent tooth with chronic apical abscess: a case report. Int Endod J 2009;42:1118-1126. https://doi.org/10.1111/j.1365-2591.2009.01633.x
  7. Forghani M, Parisay I, Maghsoudlou A. Apexogenesis and revascularization treatment procedures for two traumatized immature permanent maxillary incisors: a case report. Restor Dent Endod 2013;38:178-181. https://doi.org/10.5395/rde.2013.38.3.178
  8. Hotwani K, Sharma K. Platelet rich fibrin - a novel acumen into regenerative endodontic therapy. Restor Dent Endod 2014;39:1-6. https://doi.org/10.5395/rde.2014.39.1.1
  9. Goyal L. Clinical effectiveness of combining platelet rich fibrin with alloplastic bone substitute for the management of combined endodontic periodontal lesion. Restor Dent Endod 2014;39:51-55. https://doi.org/10.5395/rde.2014.39.1.51
  10. Hoshino E, Kurihara-Ando N, Sato I, Uematsu H, Sato M, Kota K, Iwaku M. In-vitro antibacterial susceptibility of bacteria taken from infected root dentine to a mixture of ciprofloxacin, metronidazole and minocycline. Int Endod J 1996;29:125-130. https://doi.org/10.1111/j.1365-2591.1996.tb01173.x
  11. Sato I, Ando‐Kurihara N, Kota K, Iwaku M, Hoshino E. Sterilization of infected root-canal dentine by topical application of a mixture of ciprofloxacin, metronidazole and minocycline in situ. Int Endod J 1996;29:118-124. https://doi.org/10.1111/j.1365-2591.1996.tb01172.x
  12. Hargreaves KM, Law AS. Regenerative Endodontics. In: Hargreaves KM, Cohen S, eds. Pathways of the Pulp. 10th ed. St Louis, MO: Mosby Elsevier; 2011. p602-619.
  13. Bose R, Nummikoski P, Hargreaves K. A retrospective evaluation of radiographic outcomes in immature teeth with necrotic root canal systems treated with regenerative endodontic procedures. J Endod 2009;35:1343-1349. https://doi.org/10.1016/j.joen.2009.06.021
  14. Jeeruphan T, Jantarat J, Yanpiset K, Suwannapan L, Khewsawai P, Hargreaves KM. Mahidol study 1: comparison of radiographic and survival outcomes of immature teeth treated with either regenerative endodontic or apexification methods: a retrospective study. J Endod 2012;38:1330-1336. https://doi.org/10.1016/j.joen.2012.06.028
  15. Andreasen JO, Farik B, Munksgaard EC. Long‐term calcium hydroxide as a root canal dressing may increase risk of root fracture. Dent Traumatol 2002;18:134-137. https://doi.org/10.1034/j.1600-9657.2002.00097.x
  16. Witherspoon DE, Small JC, Regan JD, Nunn M. Retrospective analysis of open apex teeth obturated with mineral trioxide aggregate. J Endod 2008;34:1171-1176. https://doi.org/10.1016/j.joen.2008.07.005
  17. Sonoyama W, Liu Y, Yamaza T, Tuan RS, Wang S, Shi S, Huang GT. Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study. J Endod 2008;34:166-171. https://doi.org/10.1016/j.joen.2007.11.021
  18. Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci U S A 2000;97:13625-13630. https://doi.org/10.1073/pnas.240309797
  19. Sonoyama W, Liu Y, Fang D, Yamaza T, Seo BM, Zhang C, Liu H, Gronthos S, Wang CY, Wang S, Shi S. Mesenchymal stem cell-mediated functional tooth regeneration in swine. PLoS One 2006;1:e79. https://doi.org/10.1371/journal.pone.0000079
  20. Lovelace TW, Henry MA, Hargreaves KM, Diogenes A. Evaluation of the delivery of mesenchymal stem cells into the root canal space of necrotic immature teeth after clinical regenerative endodontic procedure. J Endod 2011;37:133-138. https://doi.org/10.1016/j.joen.2010.10.009
  21. Kim JY, Xin X, Moioli EK, Chung J, Lee CH, Chen M, Fu SY, Koch PD, Mao JJ. Regeneration of dental-pulp-like tissue by chemotaxis-induced cell homing. Tissue Eng Part A 2010;16:3023-3031. https://doi.org/10.1089/ten.tea.2010.0181
  22. Garcia‐Godoy F, Murray PE. Recommendations for using regenerative endodontic procedures in permanent immature traumatized teeth. Dent Traumatol 2012;28:33-41. https://doi.org/10.1111/j.1600-9657.2011.01044.x
  23. Chueh LH, Huang GT. Immature teeth with periradicular periodontitis or abscess undergoing apexogenesis: a paradigm shift. J Endod 2006;32:1205-1213. https://doi.org/10.1016/j.joen.2006.07.010
  24. Chueh LH, Ho YC, Kuo TC, Lai WH, Chen YH, Chiang CP. Regenerative endodontic treatment for necrotic immature permanent teeth. J Endod 2009;35:160-164. https://doi.org/10.1016/j.joen.2008.10.019
  25. Ding RY, Cheung GS, Chen J, Yin XZ, Wang QQ, Zhang CF. Pulp revascularization of immature teeth with apical periodontitis: a clinical study. J Endod 2009;35:745-749. https://doi.org/10.1016/j.joen.2009.02.009
  26. Jung IY, Lee SJ, Hargreaves KM. Biologically based treatment of immature permanent teeth with pulpal necrosis: a case series. J Endod 2008;34:876-887. https://doi.org/10.1016/j.joen.2008.03.023
  27. Kim JH, Kim Y, Shin SJ, Park JW, Jung IY. Tooth discoloration of immature permanent incisor associated with triple antibiotic therapy: a case report. J Endod 2010;36:1086-1091. https://doi.org/10.1016/j.joen.2010.03.031
  28. Dummett CO, Thikkurissy S. Anomalies of the developing dentition. In: Casamassimo PS, Fields HW, McTigue DJ, Nowak A, eds. Pediatric dentistry. Infancy through adolescence. 5th ed. Philadelphia: WB Saunders Co.; 2013. p54-80.
  29. Thomson A, Kahler B. Regenerative endodonticsbiologically‐based treatment for immature permanent teeth: a case report and review of the literature. Aust Dent J 2010;55:446-452. https://doi.org/10.1111/j.1834-7819.2010.01268.x
  30. D'Arcangelo C, D'Amario M. Use of MTA for orthograde obturation of nonvital teeth with open apices: report of two cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;104:e98-e101. https://doi.org/10.1016/j.tripleo.2007.05.021
  31. Huang GT. A paradigm shift in endodontic management of immature teeth: conservation of stem cells for regeneration. J Dent 2008;36:379-386. https://doi.org/10.1016/j.jdent.2008.03.002
  32. Reynolds K, Johnson JD, Cohenca N. Pulp revascularization of necrotic bilateral bicuspids using a modified novel technique to eliminate potential coronal discolouration: a case report. Int Endod J 2009;42:84-92. https://doi.org/10.1111/j.1365-2591.2008.01467.x
  33. Osorio RM, Hefti A, Vertucci FJ, Shawley AL. Cytotoxicity of endodontic materials. J Endod 1998;24:91-96.

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