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In vitro combination effects of natural substances and antimicrobials against Edwardsiella tarda and Streptococcus iniae

In vitro에서 Edwardsiella tarda와 Streptococcus iniae에 대한 항균제와 천연 유래 항균물질의 병용효과

  • Bak, Su-Jin (Department of Aquatic Life Medicine, Kunsan National University) ;
  • Kang, Bong-Jo (Jeju Special Self-Governing Province Fisheries Resources Research Institute) ;
  • Park, Kwan Ha (Department of Aquatic Life Medicine, Kunsan National University)
  • 박수진 (군산대학교 해양과학대학 수산생명의학과) ;
  • 강봉조 (제주특별자치도 해양수산자원연구소) ;
  • 박관하 (군산대학교 해양과학대학 수산생명의학과)
  • Received : 2014.12.08
  • Accepted : 2015.04.17
  • Published : 2015.04.30

Abstract

The purpose of this study is to explore the possibility of essential oils and flavonoids improving the performance of antibiotics, proving a higher efficacy in the presence of natural substances against Edwardsiella tarda and Streptococcus iniae. Increased efficacy was observed in several cases: both essential oils and flavonoids increased antibacterial efficacy of oxytetracycline and flumequine against E. tarda by 2-fold; essential oils and flavonoids increased antibacterial efficacy of nalidixic acid against E. tarda by 4-fold; flavonoids increased antibacterial efficacy of josamycin against S. iniae by 4-fold. The results obtained in this study suggest that essential oils and flavonoids might be especially useful in increasing the antimicrobial activity of nalidixic acid and josamycin against E. tarda and S. iniae in fish. Natural compounds examined in this study could also be useful to help decrease the overuse of antibiotics in fish.

Keywords

References

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