Journal of the Korean Magnetic Resonance Society (한국자기공명학회논문지)

Korean Magnetic Resonance Society (한국자기공명학회)
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A new sesterterpenoid showing anti-inflammatory effect from the Marine Sponge Haliclona species

  • Lee, Kyung (Department of Marine Biotechnology, Kunsan National University) ;
  • Rho, Jung-Rae (Department of Marine Biotechnology, Kunsan National University)
  • Received : 20150431
  • Accepted : 2015.06.05
  • Published : 2015.06.30
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Abstract

Four spiroketal sestertepenoids (1 ~ 4) were isolated from the marine sponge Haliclona species. Their planar structures were completely determined from a combination of extensive 1D and 2D NMR experiments, and also the relative stereochemistry on the chiral centers were established by the ROESY experiment. Compounds 1 ~ 3 were determined as the same planar structures with different stereochemistry on the chiral centers C-11 and C-13. Of these, 1 was identified as a new stereoisomer. Four compounds showed the inhibition effect of nitric oxide (NO) production in LPS-stimulated RAW 264.7 cells (0.7~2.0 g/ml).

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