Journal of Korean Medicine for Obesity Research (한방비만학회지)

The Society of Korean Medicine for obesity Research (한방비만학회)
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Effect of Atractylodes Rhizoma Alba, Houttuyniae Herba, Lonicerae Flos, Scutellariae Radix and Coptidis Rhizoma Extracts Combined with Metformin on the Antioxidant and Adipocyte Differentiate Inhibition

백출, 어성초, 금은화, 황금, 황련과 Metformin의 병용 투여 시 항산화 효과 및 전지방세포 분화 억제 효과

  • Chang, Seju (Department of Oriental Rehabilitation Medicine, College of Korean Medicine, Dongguk University) ;
  • Han, Kyungsun (Department of Oriental Rehabilitation Medicine, College of Korean Medicine, Dongguk University) ;
  • Wang, Jing-Hua (Department of Oriental Rehabilitation Medicine, College of Korean Medicine, Dongguk University) ;
  • Chae, Hee-Sung (Department of Pharmacy, College of Pharmacy, Dongguk University) ;
  • Choi, Yong Hee (Department of Pharmacy, College of Pharmacy, Dongguk University) ;
  • Chin, Young-Won (Department of Pharmacy, College of Pharmacy, Dongguk University) ;
  • Choi, Han-Seok (Department of Endocrinology Medicine, College of Medicine, Dongguk University) ;
  • Kim, Hojun (Department of Oriental Rehabilitation Medicine, College of Korean Medicine, Dongguk University)
  • 장세주 (동국대학교 한의과대학 한방재활의학과교실) ;
  • 한경선 (동국대학교 한의과대학 한방재활의학과교실) ;
  • 왕경화 (동국대학교 한의과대학 한방재활의학과교실) ;
  • 채희성 (동국대학교 약학대학 약학교실) ;
  • 최영희 (동국대학교 약학대학 약학교실) ;
  • 진영원 (동국대학교 약학대학 약학교실) ;
  • 최한석 (동국대학교 의과대학 내분비내과교실) ;
  • 김호준 (동국대학교 한의과대학 한방재활의학과교실)
  • Received : 2015.05.18
  • Accepted : 2015.06.01
  • Published : 2015.06.30
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Abstract

Objectives: This study was to investigate the antioxiative capacity, antiobesity effects of Atractylodes Rhizoma Alba, Houttuyniae Herba, Lonicerae Flos, Scutellariae Radix, and Coptidis Rhizoma on Raw 264.7 and 3T3-L1 cell lines. Methods: Three different types of herb extracts (A. Rhizoma Alba, H. Herba, L. Flos, S. Radix, and C. Rhizoma; water 100%, ethanol 30%, ethanol 100%) were used in this study. Total polyphenol compound, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, reactive oxygen species (ROS) activity, NO production and cell proliferation were measured. Results: Total polyphenol compound measurement of L. Flos, A. Rhizogenes, and C. Rhizoma extracts were higher than A. Rhizoma Alba, H. Herba. DPPH radical scavenging activity, ROS activity and NO production of S. Radix, C. Rhizoma extracts were lower than L. Flos, A. Rhizoma, and H. Herba. Conclusions: Metformin and S. Radix, C. Rhizoma, A. Rhizoma Alba, and L. Flos extracts combination groups showed synergistic effect on adipocyte differentiation inhibition and antioxidative activity.

Keywords

References

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