대한의생명과학회지 (Biomedical Science Letters)

  • 제21권2호
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  • Pages.115-121
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  • 2015
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  • 1738-3226(pISSN)
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  • 2288-7415(eISSN)
대한의생명과학회 (The Korean Society for Biomedical Laboratory Sciences)
권호 표지
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Pulsatilla koreana Ameliorates Ddextran Sulfate Sodium-induced Ccolitis in Mice

  • Kim, Su-Jin (Department of Herbal Medicinal Pharmacology, College of Herbal Bio-industry)
  • 투고 : 2015.04.17
  • 심사 : 2015.06.22
  • 발행 : 2015.06.30
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초록

Ulcerative colitis (UC) is an inflammatory bowel disease, which is a chronic gastrointestinal disorder. Pulsatilla koreana (P. koreana) is a perennial plant that grows around Korea and it has various pharmacological effects such as anti-cancer and anti-inflammatory activity. However, the regulatory effects of P. koreana in intestinal inflammation are not yet understood. This study attempted to determine the effect of P. koreana in dextran sulfate sodium (DSS)-induced colitis in mice. The colitis mice were induced by drinking water containing 5% DSS for 7 days. The results showed that mice treated with DSS showed remarkable clinical signs, including weight loss, and reduced colon length. Administration of P. koreana attenuated DSS-induced the weight loss, colon shortening and Disease activity index in mice. Additionally, P. koreana inhibited the cyclooxygenase-2 and prostaglandin $E_2$ levels in DSS-treated colon tissues. These results provide experimental evidence that P. koreana might be a useful therapeutic medicine for patients with UC.

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참고문헌

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