Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Improved One-pot Regioselective Synthesis of 3,7-Diarylpyrazolo[1,5-α]pyrimidines and Their CB1R Activity

3,7-Diarylpyrazolo[1,5-α]pyrimidines의 개선된 One-pot Regioselective 합성과 CB1R 활성

  • 홍용덕 ((주)아모레퍼시픽 기술연구원) ;
  • 변경희 ((주)아모레퍼시픽 기술연구원) ;
  • 박미영 ((주)아모레퍼시픽 기술연구원) ;
  • 박준성 ((주)아모레퍼시픽 기술연구원) ;
  • 신송석 ((주)아모레퍼시픽 기술연구원)
  • Received : 2015.06.16
  • Accepted : 2015.06.19
  • Published : 2015.06.30
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Abstract

This study demonstrates an effective one-pot regioselective synthesis of 3,7-diarylpyrazolo [1,5-${\alpha}$]pyrimidines. Moreover, the derivatives obtained were effective CB1R antagonists. These pyrazolo [1,5-${\alpha}$]pyrimidines with diaryl groups at the 3,7-positions are potential pharmacophores for CB1R candidates.

본 연구는 3,7-diarylpyrazolo [1,5-${\alpha}$]pyrimidines의 효과적인 one-pot regioselective 합성을 보여준다. 더욱이, 그 유도체는 뛰어난 CB1R 저해 활성을 나타냈다. 3,7-position에 diaryl group이 치환된 pyrazolo [1,5-${\alpha}$]pyrimidine은 CB1R 후보로서 가능성 있는 pharmacophore이다.

Keywords

References

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