Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Effects of Korean Red Ginseng extract on busulfan-induced dysfunction of the male reproductive system

  • Jung, Seok-Won (Ginsentology Research Laboratory, Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University) ;
  • Kim, Hyeon-Joong (Ginsentology Research Laboratory, Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University) ;
  • Lee, Byung-Hwan (Ginsentology Research Laboratory, Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University) ;
  • Choi, Sun-Hye (Ginsentology Research Laboratory, Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University) ;
  • Kim, Hyun-Sook (Ginsentology Research Laboratory, Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University) ;
  • Choi, Yang-Kyu (Department of Laboratory Animal Medicine, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University) ;
  • Kim, Joon Yong (Veterinary Medical Teaching Hospital, Konkuk University) ;
  • Kim, Eun-Soo (Department of Biological Science, College of Bioscience and Biotechnology, Konkuk University) ;
  • Hwang, Sung-Hee (Department of Pharmaceutical Engineering, Sangji University) ;
  • Lim, Kwang Yong (Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University) ;
  • Kim, Hyoung-Chun (Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University) ;
  • Jang, Minhee (Department of Convergence Medical Science, College of Oriental Medicine, Kyung Hee University) ;
  • Park, Seong Kyu (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Cho, Ik-Hyun (Department of Convergence Medical Science, College of Oriental Medicine, Kyung Hee University) ;
  • Nah, Seung-Yeol (Ginsentology Research Laboratory, Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University)
  • Received : 2014.11.11
  • Accepted : 2015.01.05
  • Published : 2015.07.15
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Abstract

Background: Anticancer agents induce a variety of adverse effects when administered to cancer patients. Busulfan is a known antileukemia agent. When administered for treatment of leukemia in young patients, busulfan could cause damage to the male reproductive system as one of its adverse effects, resulting in sterility. Methods: We investigated the effects of Korean Red Ginseng extract (KRGE) on busulfan-induced damage and/or dysfunction of the male reproductive system. Results: We found that administration of busulfan to mice: decreased testis weight; caused testicular histological damage; reduced the total number of sperm, sperm motility, serum testosterone concentration; and eventually, litter size. Preadministration of KRGE partially attenuated various busulfan-induced damages to the male reproductive system. These results indicate that KRGE has a protective effect against busulfan-induced damage to the male reproduction system. Conclusion: The present study shows a possibility that KRGE could be applied as a useful agent to prevent or protect the male reproductive system from the adverse side effects induced by administration of anticancer agents such as busulfan.

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References

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