Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Radioprotective Effect of Quercetin Post-Treatment against γ-Irradiation-Induced Hepatocellular and Hematopoiectic System Damage in Mice

감마선 조사로 유도된 간세포와 조혈계 손상 마우스에서 퀘르세틴 투여 후의 방사선방호 효과

  • Kang, Jung Ae (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Yoon, Seon Hye (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Rho, Jong Kook (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Choi, Dae Seong (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Jang, Beom-Su (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Park, Sang Hyun (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
  • 강정애 (한국원자력연구원 첨단방사선연구소) ;
  • 윤선혜 (한국원자력연구원 첨단방사선연구소) ;
  • 노종국 (한국원자력연구원 첨단방사선연구소) ;
  • 최대성 (한국원자력연구원 첨단방사선연구소) ;
  • 장범수 (한국원자력연구원 첨단방사선연구소) ;
  • 박상현 (한국원자력연구원 첨단방사선연구소)
  • Received : 2015.03.04
  • Accepted : 2015.03.30
  • Published : 2015.07.31
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Abstract

This study was designed to evaluate the therapeutic effect of quercetin against radiation-induced hepatocellular and hematopoiectic damage in BALB/c mice. Mice were exposed to 6 Gy of ${\gamma}$-radiation and orally administered quercetin (25, 50 mg/kg b.w.) for 7 consecutive days. ${\gamma}$-Irradiation caused marked elevation of serum aspartate aminotransferase and alanine aminotransferase, levels as well as reduction of spleen index, thymus index, and the number of white blood cells. In addition, ${\gamma}$-irradiation induced significant elevation of lipid peroxidation as well as reduction of antioxidant enzyme activities, including superoxide dismutase, catalase, and glutathione peroxidase. However, post-treatment with quercetin resulted in a significant recovery of all of these parameters. These results suggest that quercetin acts as a potent radioprotector against irradiation-induced cellular damage in mice.

본 연구는 BALB/c 마우스에서 감마선 조사 후 퀘르세틴을 7일 동안 경구 투여하여 감마선 조사로 인한 조혈계 및 간세포 손상에 대한 방사선 회복 효과를 검토하였다. 퀘르세틴을 투여한 군은 감마선 조사군에 비해 비장 및 흉선 지수, 백혈구 수치가 증가하여 조혈 면역계 손상에 대해 보호 효과가 있음을 확인하였다. 또한 ALT와 AST의 활성도 감마선 조사군에 비해 유의적으로 감소하여 간세포 손상에 대한 보호 효과를 확인하였다. 방사선 조사에 의해 체내에서 생성된 자유라디칼은 생체물질과 결합하여 지질과산화를 일으키고 산화적 스트레스를 유도하여 조직을 손상시킨다. 퀘르세틴을 투여한 군의 지질과산화는 감마선 조사군에 유의적으로 낮게 나타나 방사선에 의한 장애를 감소시켰으며, 항산화 효소도 감마선 조사군에 비해 유의적으로 증가하여 생체 내 항산화 활성도 회복시켰다. 이상의 결과를 통해 방사선 조사후에 퀘르세틴의 투여는 방사선에 의한 조혈계 및 간세포 손상에 대해 회복 효과가 있어 방사선 보호제로 유용하게 사용될 수 있다.

Keywords

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