Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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The Effect of Poria Cocos Pharmacopuncture at SP6(Sameumgyo) and ST36(Joksamni) on Chronic Stress Model(CSM) Rats

삼음교(三陰交)(SP6)·족삼리(足三里)(ST36) 백복령약침(白茯笭藥鍼)이 만성 스트레스 모델 흰쥐에 미치는 영향

  • Kim, Seon Wook (Department of Acupuncture and Moxibustion Medicine, College of Oriental Medicine, Dongshin University) ;
  • Kim, Jae Hong (Department of Acupuncture and Moxibustion Medicine, College of Oriental Medicine, Dongshin University) ;
  • Cho, Myoung Rae (Department of Acupuncture and Moxibustion Medicine, College of Oriental Medicine, Dongshin University) ;
  • Shin, Jeong Cheol (Department of Acupuncture and Moxibustion Medicine, College of Oriental Medicine, Dongshin University)
  • 김선욱 (동신대학교 한의과대학 침구의학교실) ;
  • 김재홍 (동신대학교 한의과대학 침구의학교실) ;
  • 조명래 (동신대학교 한의과대학 침구의학교실) ;
  • 신정철 (동신대학교 한의과대학 침구의학교실)
  • Received : 2015.04.24
  • Accepted : 2015.05.27
  • Published : 2015.06.20
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Abstract

Objectives : The purpose of this study is evaluating the effect of Poria cocos pharmacopuncture (PCP) at $SP_6$(Sameumgyo) and $ST_{36}$(Joksamni) on chronic stress model(CSM) rats. Methods : The experimental rats were assigned to five groups: normal, CSM(control), PCP1X, PCP2.5X and PCP5X. The experimental rats in CSM(control), PCP1X, PCP2.5X and PCP5X were put through a timetable to cause CSM. PCP($20{\mu}l$) was administered at $SP_6$, $ST_{36}$ to groups PCP1X, PCP2.5X and PCP5X once every three days for a total of six times. The weight of the rats was measured by an electronic scale after PCP injection, once every three days for a total of six times. Blood samples were taken from the rats for analysis of aspartate aminotransferase(AST) and alanine aminotransferase(ALT). Serotonin and norepinephrine were measured by enzyme-linked immunosorbent assay(ELISA) kit. Results : The experimental groups(PCP1X, 2.5X, 5X) showed significant body weight increase compared to the control group. Regarding AST and ALT changes in serum, the experimental groups(PCP2.5X, 5X) showed a significant decrease compared to the control group. For Serotonin changes in serum, the experimental group(PCP5X) showed a significant increase compared to the control group. For Norepinephrine changes in serum, the experimental groups(PCP2.5X) showed a significant decrease compared to the control group. Conclusions : These data suggest that PCP at $SP_6$, $ST_{36}$ has therapeutic effects on CSM rats.

Keywords

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