Membrane Journal (멤브레인)

The Membrane Society of Korea (한국막학회)
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Effects of Interferents in Blood on the Blood Glucose Measurements by Using the New Type of Phosphazene Diagnostic Membranes

혈액 내 장애성분이 새로운 형태의 포스파젠 진단막을 이용한 혈당 측정에 미치는 영향

  • Kwon, Suk-Ky (Department of Biological and Chemical Engineering, Hongik University)
  • 권석기 (홍익대학교 과학기술대학 바이오화학공학과)
  • Received : 2015.05.22
  • Accepted : 2015.06.10
  • Published : 2015.06.30
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Abstract

The new types of phosphazene diagnostic membranes have been prepared for blood glucose measurements. The possible interferents in human blood were sorted into 4 different series and their effects on the glucose measurements were examined. In case of series I which indicates the lowest concentration, most of them did not show any serious effects on the blood glucose measurements, but only ascorbic acid (AA) showed 5~8% higher values compared to K/S values of the standard solution. In case of series II, all of four interferents showed 3~4% lower K/S values than those of plasma, but they showed consistent values by concentration variation. In case of series III, all of three interferents did not show any big differences compared to the standard solution. In case of series IV which indicates the highest concentration, two interferents showed 11~15% lower K/S values than the standard values, however they did not any serious effect on the blood glucose measurements.

새로운 형태의 포스파젠 진단막을 제조해 혈액 속의 글루코우즈의 농도를 측정하였다. 혈액 속에 존재할 가능성이 높은 장애성분들을 4가지 그룹으로 분류하여 혈당 측정에 미치는 영향을 조사하였다. 가장 낮은 농도를 나타내는 시리즈 I의 경우, 대부분의 첨가물들이 혈당 측정에 큰 영향을 미치지 않았으나, 오직 ascorbic acid (AA)만이 기준 용액보다 5~8% 정도 높은 K/S 결과치를 나타내었다. 시리즈 II의 경우, 네 가지 첨가물 모두 기준 용액의 K/S 결과치보다 3~4% 다소 낮은 값을 보였으나 농도에 따른 일정한 값을 보여 주었다. 시리즈 III의 경우, 세 가지 첨가물 모두 기준 용액에서 얻어지는 K/S 결과치와 큰 차이를 보이지 않았다. 가장 높은 농도를 나타내는 시리즈 IV의 경우, 두 가지 물질 모두가 기준 값보다 11~15% 정도 낮은 수치를 나타내었으나 혈당 측정에 크게 영향을 주지는 않았다.

Keywords

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