대한한방소아과학회지 (The Journal of Pediatrics of Korean Medicine)

  • 제29권2호
  • /
  • Pages.1-15
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  • 2015
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  • 1226-8038(pISSN)
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  • 2287-9463(eISSN)
대한한방소아과학회 (The Association of Korean Oriental Pediatrics)
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DNCB로 유발된 생쥐의 알레르기성 접촉피부염에 선태(蟬蛻)가 미치는 영향

Effects of Cicadae Periostracum (CP) in Allergic Contact Dermatitis (ACD) Induced by DNCB in Mice

  • 김빛나래 (동신대학교 한의과대학 소아과학교실) ;
  • 채중원 (동신대학교 한의과대학 소아과학교실)
  • Kim, Bit Na Rae (Department of Pediatrics, College of Oriental Medicine, Dongshin University) ;
  • Chae, Jung Won (Department of Pediatrics, College of Oriental Medicine, Dongshin University)
  • 투고 : 2015.04.06
  • 심사 : 2015.05.15
  • 발행 : 2015.05.31
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초록

Objectives In the theory of Korean Medicine, Cicadae Periostracum (CP) has been used to treat skin diseases such as inflammatory dermatitis, tetanus and pruritus. CP can reduce heat and disperse wind. In prior studies, anti-allergic effect and anti-inflammatory effect of CP were reported. However, there has been no report regarding the correlation of CP and allergic contact dermatitis (ACD). This study was performed to show the effects of CP in ACD induced by 2,4-dinitrochlorobenzene (DNCB) in mice. Methods In this experiment, the effects of CP on biological changes were measured, such as changes in ear and spleen weight, ear and dorsum skin thickness, clinical aspect on the dorsum skin and histological changes. The effect of proliferation rate of splenocytes was also investigated in vitro and vivo study. Results In results, CP application (CPA) group and CP application and administration (CPAA) group were significantly restrained in ear weight gain and increase in ear and dorsum skin thickness compared to the control group. In addition, CPA and CPAA group showed diminished erythema, desquamation, bloodstain, and marks. Also, the histological assessment showed that CP treatement diminished thickness of epidermis, hyperkeratosis, pigmentation and parakeratosis. Conclusions In conclusion, these data suggest that CP can decrease symptoms of ACD.

키워드

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피인용 문헌

  1. Comparative Morphological, Ultrastructural, and Molecular Studies of Four Cicadinae Species Using Exuvial Legs vol.10, pp.7, 2015, https://doi.org/10.3390/insects10070199