한국식품영양과학회지 (Journal of the Korean Society of Food Science and Nutrition)

  • 제44권4호
  • /
  • Pages.491-496
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  • 2015
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  • 1226-3311(pISSN)
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  • 2288-5978(eISSN)
한국식품영양과학회 (The Korean Society of Food Science and Nutrition)
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대봉감의 항산화, 항염증 및 면역증강 효과

Beneficial Effects of Daebong Persimmon against Oxidative Stress, Inflammation, and Immunity in vivo

  • 이희재 (전남대학교 식품영양과학부.생활과학연구소) ;
  • 임소영 (전남대학교 식품영양과학부.생활과학연구소) ;
  • 강민경 (전남대학교 식품영양과학부.생활과학연구소) ;
  • 박정진 (전남대학교 식품영양과학부.생활과학연구소) ;
  • 정현정 (전남대학교 식품영양과학부.생활과학연구소) ;
  • 양수진 (서울여자대학교 식품영양학과)
  • Lee, Hee Jae (Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University) ;
  • Lim, So Young (Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University) ;
  • Kang, Min-Gyung (Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University) ;
  • Park, Jeongjin (Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University) ;
  • Chung, Hyun-Jung (Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University) ;
  • Yang, Soo Jin (Department of Food and Nutrition, Seoul Women's University)
  • 투고 : 2014.12.05
  • 심사 : 2014.12.23
  • 발행 : 2015.04.30
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초록

본 연구는 대표적인 떫은 감 품종인 대봉감과 반시의 항산화, 항염증 및 면역증강 효과를 탐색, 비교하였다. 쥐 모델을 대상으로 4주간 대봉감과 반시의 섭취는 식이섭취량과 체중 변화에 영향을 미치지 않았다. B지역의 대봉감 섭취는 고지방식이 대조군 대비 유의적으로 카탈레이즈 활성 수준을 증가시켰으며, 간 조직의 지질과산화물인 말론디알데하이드 수준은 고지방식이 대조군 대비 A지역 대봉감을 섭취한 군에서 유의적으로 감소하였다. 또한 A지역 대봉감의 섭취는 염증인자인 IL-1 beta의 수준을 고지방식이군 대비 유의적으로 감소시켰다. 또 다른 대표적인 염증인자인 IL-6는 고지방식이 대조군과 비교하여 A지역과 B지역의 대봉감을 섭취한 군에서 유의적으로 감소시켰다. TNF-alpha 수준은 A지역의 대봉감을 섭취한 군에서 고지방식이대조군 대비 유의적으로 감소되었다. A지역 대봉감 섭취는 IgG의 수준을 고지방식이 대조군 대비 유의적으로 증가시켰다. IGF-1의 수준은 고지방식이 대조군과 비교하여 A, B, C 지역 대봉감 섭취군에서 증가하였다. 이상의 결과로부터 대봉감의 섭취는 우수한 항염증 효과와 면역증강 효과가 있을 것으로 사료된다.

The purpose of this study was to assess the antioxidant, anti-inflammatory, and immuno-enhancing effects of Daebong persimmon (DP) and Bansi (BS) in vivo. Two types of astringent persimmons (DP and BS) were used for this experiment. C57BL/6J mice were assigned to the following groups: 1) lean control, 2) high-fat diet control (HF), 3) A region DP (3% wt/wt) with HF diet (A-DP), 4) B region DP with HF diet (B-DP), 5) C region DP with HF diet (C-DP), 6) D region BS with HF diet (D-BS), and 7) E region BS with HF diet (E-BS). All mice were sacrificed after 4 weeks of treatment, after which blood and tissues were collected. Antioxidant enzyme activities, inflammatory markers, and immune factors were evaluated. DP and BS treatments did not alter food intake or body weight, compared with HF. Administration of B-DP increased catalase activities in serum. Hepatic levels of malondialdehyde, a product of lipid peroxidation, were significantly lower in A-DP mice than in the HF group. A-DP had down-regulatory effects against inflammation induced by high-fat diet feeding, as shown by significant reduction of interleukin (IL)-$1{\beta}$, IL-6, and tumor necrosis factor-${\alpha}$. Additionally, A-DP treatment exerted an immuno-stimulatory effect, as shown by increasing levels of immunoglobulin G. DP treatment improved the level of insulin-like growth factor-1. These results indicate that DP has beneficial health effects on oxidative stress, inflammation, and immunity in vivo.

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참고문헌

  1. Lee HK. 1996. Korean disease pattern and nutrition. Korean J Nutr 29: 381-383.
  2. Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB. 2010. Oxidative stress, inflammation, and cancer: How are they linked? Free Radicals Biol Med 49: 1603-1616. https://doi.org/10.1016/j.freeradbiomed.2010.09.006
  3. Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, Nakayama O, Makishima M, Matsuda M, Shimomura I. 2004. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 114: 1752-1761. https://doi.org/10.1172/JCI21625
  4. Halliwell B. 1996. Antioxidants in human health and disease. Annu Rev Nutr 16: 33-50. https://doi.org/10.1146/annurev.nu.16.070196.000341
  5. Hotamisligil GS. 2006. Inflammation and metabolic disorders. Nature 444: 860-867. https://doi.org/10.1038/nature05485
  6. Lin WW, Karin M. 2007. A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest 117: 1175-1183. https://doi.org/10.1172/JCI31537
  7. Kimata H, Fujimoto M. 1994. Growth hormone and insulin-like growth factor I induce immunoglobulin (Ig)E and IgG4 production by human B cells. J Exp Med 180: 727-732. https://doi.org/10.1084/jem.180.2.727
  8. Matsuo T, Itoo S, Ben-Arie R. 1991. A model experiment for elucidating the mechanism of astringency removal in persimmon fruit using respiration inhibitors. J Japan Soc Hort Sci 60: 437-442. https://doi.org/10.2503/jjshs.60.437
  9. Hong JS, Chae KY. 2005. Physicochemical characteristics and antioxidant activity of astringent persimmon concentrate by boiling. Korean J Food Cookery Sci 21: 709-716.
  10. Kim Y, Lee S, Kim M, Kim G, Chung HS, Park HJ, Kim MO, Kwon JH. 2009. Physicochemical and organoleptic qualities of sliced-dried persimmons as affected by drying methods. Korean J Food Sci Technol 41: 64-68.
  11. Haslam E. 1979. Vegetable tannins. In Biochemistry of Plant Phenolics. Swain T, Harbone JB, Van Sumere CF, eds. Springer, New York, NY, USA. p 475-523.
  12. Achiwa Y, Hibasmi H, Katsuzaki H, Iami K, Komiya T. 1997. Inhibitory effects of persimmon (Diospyros kaki) extract and related polyphenol compounds on growth by human lymphoid leukemia cells. Biosci Biotechnol Biochem 61: 1099-1101. https://doi.org/10.1271/bbb.61.1099
  13. Jo YH, Park JW, Lee JM, Ahn GH, Park HR, Lee SC. 2010. Antioxidant and anticancer activities of methanol extracts prepared from different parts Jangseong daebong persimmon (Diospyros kaki cv. Hachiya). J Korean Soc Food Sci Nutr 39: 500-505. https://doi.org/10.3746/jkfn.2010.39.4.500
  14. Gorinstein S, Kulasek GW, Bartnikowska E, Leontowicz M, Zemser M, Morwiec M, Trakhtenberg S. 2000. The effects of diets, supplemented with either whole persimmon or phenol-free persimmon, on rat fed cholesterol. Food Chem 70: 303-308. https://doi.org/10.1016/S0308-8146(00)00072-8
  15. Alvarez-Suarez JM, Dekanski D, Ristic S, Radonjic NV, Petronijevic ND, Giampieri F, Astolfi P, Gonzalez-Paramas AM, Santos-Buelga C, Tulipani S, Quiles JL, Mezzetti B, Battino M. 2011. Strawberry polyphenols attenuate ethanol-induced gastric lesions in rats by activation of antioxidant enzymes and attenuation of MDA increase. PLoS One 6: e25878. https://doi.org/10.1371/journal.pone.0025878
  16. Gabay C, Lamacchia C, Palmer G. 2010. IL-1 pathways in inflammation and human diseases. Nat Rev Rheumatol 6: 232-241. https://doi.org/10.1038/nrrheum.2010.4
  17. Scheller J, Garbers C, Rose-John S. 2014. Interleukin-6: from basic biology to selective blockade of pro-inflammatory activities. Semin Immunol 26: 2-12. https://doi.org/10.1016/j.smim.2013.11.002
  18. Vilcek J, Lee TH. 1991. Tumor necrosis factor. New insights into the molecular mechanisms of its multiple actions. J Biol Chem 266: 7313-7316.
  19. Naczk M, Shahidi F. 2004. Extraction and analysis of phenolics in food. J Chromatogr A 1054: 95-111. https://doi.org/10.1016/S0021-9673(04)01409-8
  20. Gonzalez-Gallego J, Garcia-Mediavilla MV, Sanchez-Campos S, Tunon MJ. 2010. Fruit polyphenols, immunity and inflammation. Br J Nutr 104: S15-S27. https://doi.org/10.1017/S0007114510003910
  21. Bogden JD, Oleske JM, Munves EM, Lavenhar MA, Bruening KS, Kemp FW, Holding KJ, Denny TN, Louria DB. 1987. Zinc and immunocompetence in the elderly: baseline data on zinc nutriture and immunity in unsupplemented subjects. Am J Clin Nutr 46: 101-109.
  22. Caughey GE, Mantzioris E, Gibson RA, Cleland LG, James MJ. 1996. The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. Am J Clin Nutr 63: 116-122.
  23. Chandra RK. 1992. Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. Lancet 340: 1124-1127. https://doi.org/10.1016/0140-6736(92)93151-C
  24. Daly JM, Reynolds J, Sigal RK, Shou J, Liberman MD. 1990. Effect of dietary protein and amino acids on immune function. Crit Care Med 18: S86-S93. https://doi.org/10.1097/00003246-199002003-00001
  25. Peretz A, Neve J, Desmedt J, Duchateau J, Dramaix M, Famaey JP. 1991. Lymphocyte response is enhanced by supplementation of elderly subjects with selenium-enriched yeast. Am J Clin Nutr 53: 1323-1328.
  26. Kau AL, Ahern PP, Griffin NW, Goodman AL, Gordon JI. 2011. Human nutrition, the gut microbiome and the immune system. Nature 474: 327-336. https://doi.org/10.1038/nature10213
  27. Guevara-Aguirre J. 1996. Insulin-like growth factor I - an important intrauterine growth factor. N Engl J Med 335: 1389-1391. https://doi.org/10.1056/NEJM199610313351810
  28. Badolato R, Bond HM, Valerio G, Petrella A, Morrone G, Waters MJ, Venuta S, Tenore A. 1994. Differential expression of surface membrane growth hormone receptor on human peripheral blood lymphocytes detected by dual fluorochrome flow cytometry. J Clin Endocrinol Metab 79: 984-990
  29. Heemskerk VH, Daemen MA, Buurman WA. 1999. Insulinlike growth factor-1 (IGF-1) and growth hormone (GH) in immunity and inflammation. Cytokine Growth Factor Rev 10: 5-14. https://doi.org/10.1016/S1359-6101(98)00022-7
  30. Stuart CA, Meehan RT, Neale LS, Cintron NM, Furlanetto RW. 1991. Insulin-like growth factor- I binds selectively to human peripheral blood monocytes and B-lymphocytes. J Clin Endocrinol Metab 72: 1117-1122. https://doi.org/10.1210/jcem-72-5-1117

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