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Multiple Subcutaneous Nodular Metastasis from Transitional Cell Carcinoma of the Urinary Bladder in a Dog

한마리 개에서 발생한 방광 이행상피세포암종으로 인한 다수의 피하 전이

  • Kim, Hye-young (College of Veterinary Medicine, Chungnam National University) ;
  • Hong, Eun-ji (College of Veterinary Medicine, Chungnam National University) ;
  • Park, Hyung-jin (College of Veterinary Medicine, Chungnam National University) ;
  • Kwon, Hyo-jung (College of Veterinary Medicine, Chungnam National University) ;
  • Song, Kun-ho (College of Veterinary Medicine, Chungnam National University) ;
  • Seo, Kyoung-won (College of Veterinary Medicine, Chungnam National University)
  • 김혜영 (충남대학교 수의과대학) ;
  • 홍은지 (충남대학교 수의과대학) ;
  • 박형진 (충남대학교 수의과대학) ;
  • 권효정 (충남대학교 수의과대학) ;
  • 송근호 (충남대학교 수의과대학) ;
  • 서경원 (충남대학교 수의과대학)
  • Accepted : 2015.05.18
  • Published : 2015.06.30

Abstract

A 10-year-old spayed female Pomeranian dog weighing 3.65 kg was presented with a 7-month history of urinary incontinence, stranguria and hematuria. The patient had mass lesions at left prescapular region ($3cm{\times}3cm$) and left axillary region ($5cm{\times}4cm$). Diagnosis of transitional cell carcinoma (TCC) with multiple cutaneous metastasis was made. Dog was treated with chemotherapy using mitoxantrone and piroxicam for 5 months. Although TCC size of urinary bladder was decreased during chemotherapy, there was no change of subcutaneous tumor size and mild relief of clinical signs. Partial anorexia for 3 weeks and multiple masses were noted at left caudal abdominal wall and left medial thigh (203 days after first presentation) and assessed as chronic kidney disease and additional subcutaneous metastasis of urinary bladder TCC by post-mortem and histopathological findings.

10년령 몸무게 3.65 kg의 암컷 포메라니안이 7개월동안 지속된 요실금, 통증배뇨 및 혈뇨를 주 증으로 진료 의뢰되었다. 환자는 좌측 전견갑 부위와 좌측 겨드랑이 부위에 종괴가 확인되었다. 신체검사 및 기본검사를 통해 방광 이행상피세포암종과 이로 인한 피하 전이로 잠정 진단 하였으며, 미톡산트론과 피록시캄을 병용한 6 cycle의 항암 치료를 실시하였다. 항암 치료 기간 동안, 방광 이행상피세포암종의 크기는 점차적으로 작아졌지만, 피하 종양의 크기는 변화가 없었으며 임상증상의 개선도 미약했다. 첫 내원 후 203일째, 3주 동안의 식욕부진과 왼쪽 뒤쪽 복벽 및 왼쪽 안쪽 허벅지에 다수의 종양을 주 증으로 다시 내원하였고, 안락사 하였다. 환자는 사후 부검과 조직병리검사를 통해 만성신장질환과 방광 이행상피세포암종의 추가적인 피하 전이로 확진되었다.

Keywords

References

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