한국약용작물학회지 (Korean Journal of Medicinal Crop Science)

  • 제23권4호
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  • Pages.298-304
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  • 2015
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  • 1225-9306(pISSN)
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  • 2288-0186(eISSN)
한국약용작물학회 (The Korean Society of Medicinal Crop Science)
권호 표지
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환초석곡 메탄올 추출물의 흑색종세포주에서 멜라닌 생성 억제 효능

Effect of Dendrobium loddigesii Rolfe Methanol Extract on Melanogenesis in α-MSH Stimulated B16F10 Cells

  • Jung, Ho Kyung (Jeollanamdo Development Institute of Traditional Korean Medicine) ;
  • Jang, Ji Hun (Jeollanamdo Development Institute of Traditional Korean Medicine) ;
  • Sim, Mi Ok (Jeollanamdo Development Institute of Traditional Korean Medicine) ;
  • Lee, Ki Ho (Jeollanamdo Development Institute of Traditional Korean Medicine) ;
  • Yeo, Jun Hwan (Jeollanamdo Development Institute of Traditional Korean Medicine) ;
  • Kang, Byoung Man (Jeollanamdo Development Institute of Traditional Korean Medicine) ;
  • Cho, Jung Hee (Jeollanamdo Development Institute of Traditional Korean Medicine) ;
  • Bean, Chul Gu (Research Institute, Gyeongsangnamdo Agricultural Research and Extension Services) ;
  • Kim, Seong Cheol (Namhae Sub-Station, National Institute of Horticultural and Herbal Science, RDA) ;
  • Jung, Won Seok (Jeollanamdo Development Institute of Traditional Korean Medicine)
  • 투고 : 2015.06.08
  • 심사 : 2015.07.22
  • 발행 : 2015.08.30
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초록

Dendrobium loddigesii (DL) is a valuable and versatile herbal medicine with the anecdotal claims of anti-oxidant and anti-inflammation. In the present study, we investigated the whitening effects of DL under various conditions with B16F10 melanoma cells. The DL extract inhibited melanin contents and tyrosinase activity in a dose-dependent manner, compared with untreated group. Treatment of the DL extract effectively suppressed the ${\alpha}$-MSH-stimulated melanin formation, tyrosinase activity and dendrite outgrowth. Moreover, the ${\alpha}$-MSH-induced mRNA expressions of tyrosinase-related protein-1 (TRP-1), tyrosinase-related protein-2 (TRP-2), microphthalmia-associated transcription factor (MITF) and protein expression of tyrosinase were significantly attenuated by DL treatment. These results indicate that DL may be a great cosmeceutical ingredient for its whitening effects.

키워드

참고문헌

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피인용 문헌

  1. Whitening and Anti-Wrinkle Effects of Tremella fuciformis Extracts vol.24, pp.1, 2016, https://doi.org/10.7783/KJMCS.2016.24.1.38