한국약용작물학회지 (Korean Journal of Medicinal Crop Science)

  • 제23권4호
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  • Pages.324-333
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  • 2015
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  • 1225-9306(pISSN)
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  • 2288-0186(eISSN)
한국약용작물학회 (The Korean Society of Medicinal Crop Science)
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일엽초 추출물의 항산화 및 항암 효과

Antioxidant and Anticancer Properties of the Extracts from Lepisorus thunbergianus (Kaulf.) Ching

  • ;
  • 권용수 (강원대학교 약학대학 약학과) ;
  • 임정대 (강원대학교 생약자원개발학과) ;
  • 유창연 (강원대학교 식물자원응용공학과) ;
  • 김명조 (강원대학교 식물자원응용공학과)
  • Yang, Jinfeng (Bioherb Research Institute, Kangwon National University) ;
  • Kwon, Yong Soo (Department of Pharmacy, Kangwon National University) ;
  • Lim, Jung Dae (Department of Herbal Medicine Resource, Kangwon National University) ;
  • Yu, Chang Yeon (Department of Applied plant sciences, Kangwon National University) ;
  • Kim, Myong Jo (Department of Applied plant sciences, Kangwon National University)
  • 투고 : 2015.07.17
  • 심사 : 2015.08.06
  • 발행 : 2015.08.30
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초록

Lepisorus thunbergianus (Kaulf.) Ching has been used in folk medicine in Korea. In this study, a L. thunbergianus methanol extract and its fractions were investigated for their antioxidant properties. The results showed that the ethyl acetate and butanol fractions of L. thunbergianus possess potent DPPH radical scavenging activities. Both fractions also possessed reducing power and inhibited reactive oxygen species formation. In addition, the cytotoxic activity of the L. thunbergianus n-hexane fraction (HF) was investigated. The results suggested that the HF remarkably suppressed proliferation of human breast, liver and colon cancer cells. These results demonstrate, for the first time, that L. thunbergianus extract induces apoptosis in SW620 cells, suggesting that L. thunbergianus may have potential as a therapeutic agent for colon cancer.

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