Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Establishing a Nomogram for Stage IA-IIB Cervical Cancer Patients after Complete Resection

  • Zhou, Hang (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Li, Xiong (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Zhang, Yuan (Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology) ;
  • Jia, Yao (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Hu, Ting (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Yang, Ru (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Huang, Ke-Cheng (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Chen, Zhi-Lan (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Wang, Shao-Shuai (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Tang, Fang-Xu (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Zhou, Jin (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Chen, Yi-Le (Department of Gynecologic Neoplasms, Hunan Province Tumor Hospital, The Affiliated Tumor Hospital of Central South University) ;
  • Wu, Li (Department of Gynecologic Neoplasms, Hunan Province Tumor Hospital, The Affiliated Tumor Hospital of Central South University) ;
  • Han, Xiao-Bing (The First Affiliated Hospital, Medical School of Xi'an Jiaotong University) ;
  • Lin, Zhong-Qiu (The Second Affiliated Hospital, Sun Yat-sen University) ;
  • Lu, Xiao-Mei (The Second Affiliated Hospital, Sun Yat-sen University) ;
  • Xing, Hui (Xiangyang Central Hospital, First Affiliated Hospital of Hubei University of Arts and Science) ;
  • Qu, Peng-Peng (Tianjin Central Hospital for Gynecology and Obstetrics) ;
  • Cai, Hong-Bing (Zhong Nan Hospital, Wuhan University) ;
  • Song, Xiao-Jie (Commercial Vocational Hospital) ;
  • Tian, Xiao-Yu (The First Affiliated Hospital of Henan University of Science and Technology) ;
  • Zhang, Qing-Hua (The Central Hospital of Wuhan) ;
  • Shen, Jian (The Central Hospital of Wuhan) ;
  • Liu, Dan (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Wang, Ze-Hua (Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology) ;
  • Xu, Hong-Bing (Shenzhen People's Hospital, the Second Clinical Hospital of Jinan University) ;
  • Wang, Chang-Yu (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Xi, Ling (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Deng, Dong-Rui (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Wang, Hui (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Lv, Wei-Guo (Women's Reproductive Health Laboratory of Zhejiang Province) ;
  • Shen, Keng (Department Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College) ;
  • Wang, Shi-Xuan (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Xie, Xing (Women's Reproductive Health Laboratory of Zhejiang Province) ;
  • Cheng, Xiao-Dong (Women's Reproductive Health Laboratory of Zhejiang Province) ;
  • Ma, Ding (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Li, Shuang (Department of Obstetrics and Gynecology, Tongji Hospital)
  • Published : 2015.05.18
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Abstract

Background: This study aimed to establish a nomogram by combining clinicopathologic factors with overall survival of stage IA-IIB cervical cancer patients after complete resection with pelvic lymphadenectomy. Materials and Methods: This nomogram was based on a retrospective study on 1,563 stage IA-IIB cervical cancer patients who underwent complete resection and lymphadenectomy from 2002 to 2008. The nomogram was constructed based on multivariate analysis using Cox proportional hazard regression. The accuracy and discriminative ability of the nomogram were measured by concordance index (C-index) and calibration curve. Results: Multivariate analysis identified lymph node metastasis (LNM), lymph-vascular space invasion (LVSI), stromal invasion, parametrial invasion, tumor diameter and histology as independent prognostic factors associated with cervical cancer survival. These factors were selected for construction of the nomogram. The C-index of the nomogram was 0.71 (95% CI, 0.65 to 0.77), and calibration of the nomogram showed good agreement between the 5-year predicted survival and the actual observation. Conclusions: We developed a nomogram predicting 5-year overall survival of surgically treated stage IA-IIB cervical cancer patients. More comprehensive information that is provided by this nomogram could provide further insight into personalized therapy selection.

Keywords

References

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