Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Consanguinity Protecting Effect Against Breast Cancer among Tunisian Women: Analysis of BRCA1 Haplotypes

  • Medimegh, Imen (Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences of Tunis, University El Manar) ;
  • Troudi, Wafa (Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences of Tunis, University El Manar) ;
  • Omrane, Ines (Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences of Tunis, University El Manar) ;
  • Ayari, Hajer (Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences of Tunis, University El Manar) ;
  • Uhrhummer, Nancy (Laboratoire de Diagnostic Genetique et Moleculaire) ;
  • Majoul, Hamdi (Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences of Tunis, University El Manar) ;
  • Benayed, Farhat (Salah Azaiez Institute of Carcinology of Tunis) ;
  • Mezlini, Amel (Salah Azaiez Institute of Carcinology of Tunis) ;
  • Bignon, Yves-Jean (Laboratoire de Diagnostic Genetique et Moleculaire) ;
  • Sibille, Catherine (Laboratory of Molecular Genetic of Hereditary Pathologies) ;
  • Elgaaied, Amel Benammar (Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences of Tunis, University El Manar)
  • Published : 2015.05.18
Download PDF
⟨ Previous Next ⟩

Abstract

The purpose of this study is to assess the effect of consanguinity on breast cancer incidence in Tunisia. We conducted a case-control study to evaluate the involvement of heterozygote and homozygote haplotypes of BRCA1 gene SNPs according to consanguinity among 40 cases of familial breast cancer, 46 cases with sporadic breast cancer and 34 healthy controls. We showed significant difference in consanguinity rate between breast cancer patients versus healthy controls P=0.001. Distribution of homozygous BRCA1 haplotypes among healthy women versus breast cancer patients was significantly different; p=0.02. Parental consanguinity seems to protect against breast cancer in the Tunisian population.

Keywords

References

  1. Abu-Rabia S, Maroun L (2005). The effect of consanguineous marriage on reading disability in the Arab community. Dyslexia, 11, 1-21. https://doi.org/10.1002/dys.271
  2. Cao W, Wang X, Gao Y, et al (2013). BRCA1 germ-line mutations and tumor characteristics in eastern Chinese women with familial breast cancer. Anat Rec, 296, 273-8. https://doi.org/10.1002/ar.22628
  3. Consortium AU-ACR (2008). Cancer registration literature update (2006-2008). Asian Pac J Cancer Prev, 9, 165-82.
  4. Denic S, Bener A (2001). Consanguinity decreases risk of breast cancer--cervical cancer unaffected. Br J Cancer, 85, 1675-9. https://doi.org/10.1054/bjoc.2001.2131
  5. Denic S, Frampton C, Nicholls MG (2007). Risk of cancer in an inbred population. Cancer Detect Prev, 31, 263-9. https://doi.org/10.1016/j.cdp.2007.07.006
  6. Elalaoui SC, Jaouad IC, Laarabi FZ, et al (2013). Low level of consanguinity in moroccan families at high risk of breast cancer. Asian Pac J Cancer Prev, 14, 723-6. https://doi.org/10.7314/APJCP.2013.14.2.723
  7. Grjibovski AM, Magnus P, Stoltenberg C (2009). Decrease in consanguinity among parents of children born in Norway to women of Pakistani origin: a registry-based study. Scand J Public Health, 37, 232-8. https://doi.org/10.1177/1403494808100939
  8. Hamamy H, Alwan A (1994). Hereditary disorders in the Eastern Mediterranean Region. Bull WHO, 72, 145-54.
  9. Hohenstein P, Kielman MF, Breukel C, et al (2001). A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage. Oncogene, 20, 2544-50. https://doi.org/10.1038/sj.onc.1204363
  10. Holloway SM, Sofaer JA (1990). Coefficients of relationship by isonymy among the parents of Scottish twins: a test of familial aggregation. Hum Biol, 62, 429-35.
  11. Khlat M, Khoury M (1991). Inbreeding and diseases: demographic, genetic, and epidemiologic perspectives. Epidemiol Rev, 13, 28-41.
  12. Liascovich R, Rittler M, Castilla EE (2001). Consanguinity in South America: demographic aspects. Hum Hered, 51, 27-34. https://doi.org/10.1159/000022956
  13. Maalej M, Hentati D, Messai T, et al (2008). Breast cancer in Tunisia in 2004: a comparative clinical and epidemiological study. Bull Cancer, 95, 5-9.
  14. Moore MA (2013). Overview of cancer registration research in the Asian Pacific from 2008-2013. Asian Pac J Cancer Prev, 14, 4461-84. https://doi.org/10.7314/APJCP.2013.14.8.4461
  15. Moore MA, Sangrajrang S, Bray F (2014). Asian Cancer Registry Forum 2014 - regional cooperation for cancer registration: priorities and challenges. Asian Pac J Cancer Prev, 15, 1891-4. https://doi.org/10.7314/APJCP.2014.15.5.1891
  16. Smith MT (2001). Estimates of cousin marriage and mean inbreeding in the United Kingdom from 'birth briefs'. J Biosoc Sci, 33, 55-66. https://doi.org/10.1017/S0021932001000554
  17. Troudi W, Uhrhammer N, Sibille C, et al (2007). Contribution of the BRCA1 and BRCA2 mutations to breast cancer in Tunisia. J Hum Genet, 52, 915-20. https://doi.org/10.1007/s10038-007-0195-5
  18. Williams CK, Cristina Stefan D, Rawlinson F, et al (2014). The African Organisation for Research and Training in Cancer and its conferences: a historical perspective and highlights of the Ninth International Conference, Durban, South Africa, 21-24 November 2013. Ecancermedicalscience, 8, 396.

Cited by

  1. Breast cancer protection by genomic imprinting in close kin families vol.18, pp.1, 2017, https://doi.org/10.1186/s12881-017-0498-0
  2. A meta-analysis of consanguinity and breast cancer vol.187, pp.4, 2018, https://doi.org/10.1007/s11845-018-1791-4
  3. A genome wide SNP genotyping study in the Tunisian population: specific reporting on a subset of common breast cancer risk loci vol.18, pp.1, 2018, https://doi.org/10.1186/s12885-018-5133-8