Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Depression and the Risk of Breast Cancer: A Meta-Analysis of Cohort Studies

  • Sun, Hui-Lian (School of Public Health, Tongji Medical College, Huazhong University of Science and Technology) ;
  • Dong, Xiao-Xin (School of Public Health, Tongji Medical College, Huazhong University of Science and Technology) ;
  • Cong, Ying-Jie (School of Public Health, Tongji Medical College, Huazhong University of Science and Technology) ;
  • Gan, Yong (School of Public Health, Tongji Medical College, Huazhong University of Science and Technology) ;
  • Deng, Jian (School of Public Health, Tongji Medical College, Huazhong University of Science and Technology) ;
  • Cao, Shi-Yi (School of Public Health, Tongji Medical College, Huazhong University of Science and Technology) ;
  • Lu, Zu-Xun (School of Public Health, Tongji Medical College, Huazhong University of Science and Technology)
  • Published : 2015.04.29
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Abstract

Background: Whether depression causes increased risk of the development of breast cancer has long been debated. We conducted an updated meta-analysis of cohort studies to assess the association between depression and risk of breast cancer. Materials and Methods: Relevant literature was searched from Medline, Embase, Web of Science (up to April 2014) as well as manual searches of reference lists of selected publications. Cohort studies on the association between depression and breast cancer were included. Data abstraction and quality assessment were conducted independently by two authors. Random-effect model was used to compute the pooled risk estimate. Visual inspection of a funnel plot, Begg rank correlation test and Egger linear regression test were used to evaluate the publication bias. Results: We identified eleven cohort studies (182,241 participants, 2,353 cases) with a follow-up duration ranging from 5 to 38 years. The pooled adjusted RR was 1.13(95% CI: 0.94 to 1.36; $I^2=67.2%$, p=0.001). The association between the risk of breast cancer and depression was consistent across subgroups. Visual inspection of funnel plot and Begg's and Egger's tests indicated no evidence of publication bias. Regarding limitations, a one-time assessment of depression with no measure of duration weakens the test of hypothesis. In addition, 8 different scales were used for the measurement of depression, potentially adding to the multiple conceptual problems concerned with the definition of depression. Conclusions: Available epidemiological evidence is insufficient to support a positive association between depression and breast cancer.

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References

  1. Begg CB, Mazumdar M (1994). Operating characteristics of a rank correlation test for publication bias. Biometrics, 50, 1088-101. https://doi.org/10.2307/2533446
  2. Benson JR, Jatoi I (2012). The global breast cancer burden. Future Oncol, 8, 697-702. https://doi.org/10.2217/fon.12.61
  3. Buntinx F, De Lepeleire J, Heyrman J, et al (2004). Diagnosing depression: what's in a name? Eur J Gen Pract, 10, 162-5. https://doi.org/10.3109/13814780409044305
  4. Chen YH, Lin HC (2011). Increased risk of cancer subsequent to severe depression--a nationwide population-based study. J Affect Disord, 131, 200-6. https://doi.org/10.1016/j.jad.2010.12.006
  5. Dalton SO, Mellemkjaer L, Olsen JH, et al (2002). Depression and cancer risk: a register-based study of patients hospitalized with affective disorders, Denmark, 1969-1993. Am J Epidemiol, 155, 1088-95. https://doi.org/10.1093/aje/155.12.1088
  6. DerSimonian R, Laird N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88. https://doi.org/10.1016/0197-2456(86)90046-2
  7. Duval S, Tweedie R (2000). Trim and fill: A simple funnel-plotbased method of testing and adjusting for publication bias in meta-analysis. Biometrics, 56, 455-63. https://doi.org/10.1111/j.0006-341X.2000.00455.x
  8. Egger M, Smith GD, Schneider M, et al (1997). Bias in metaanalysis detected by a simple, graphical test. Bmj, 315, 629-34. https://doi.org/10.1136/bmj.315.7109.629
  9. Friberg S, Mattson S (1997). On the growth rates of human malignant tumors: implications for medical decision making. J Surg Oncol, 65, 284-97. https://doi.org/10.1002/(SICI)1096-9098(199708)65:4<284::AID-JSO11>3.0.CO;2-2
  10. Gail MH, Brinton LA, Byar DP, et al (1989). Projecting individualized probabilities of developing breast cancer for white females who are being examined annually. J Natl Cancer Inst, 81, 1879-86. https://doi.org/10.1093/jnci/81.24.1879
  11. Goldacre MJ, Wotton CJ, Yeates D, et al (2007). Cancer in people with depression or anxiety: record-linkage study. Soc Psychiatry Psychiatr Epidemiol, 42, 683-9. https://doi.org/10.1007/s00127-007-0211-2
  12. Gross AL, Gallo JJ, Eaton WW (2010). Depression and cancer risk: 24 years of follow-up of the Baltimore Epidemiologic Catchment Area sample. Cancer Causes Control, 21, 191-9. https://doi.org/10.1007/s10552-009-9449-1
  13. Hahn RC, Petitti DB (1988). Minnesota Multiphasic Personality Inventory-Rated Depression and the incidence of breast cancer. Cancer, 61, 845-8. https://doi.org/10.1002/1097-0142(19880215)61:4<845::AID-CNCR2820610434>3.0.CO;2-Q
  14. Higgins JP, Thompson SG, Deeks JJ, et al (2003). Measuring inconsistency in meta-analyses. Bmj, 327, 557-60. https://doi.org/10.1136/bmj.327.7414.557
  15. International Agency for Research on Cancer (2008). Breast cancer incidence, mortality and prevalence worldwide in 2008 summary [online]. available: http://globocan.iarc.fr/factsheet.asp.
  16. Jacobs JR, Bovasso GB (2000). Early and chronic stress and their relation to breast cancer. Psychol Med, 30, 669-78. https://doi.org/10.1017/S0033291799002020
  17. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  18. Kampert JB, Whittemore AS, Paffenbarger RS, et al (1988). Combined effect of childbearing, menstrual events, and body size on age-specific breast cancer risk. Am J Epidemiol, 128, 962-79.
  19. Kessler RC, Berglund P, Demler O, et al (2003). The epidemiology of major depressive disorder: results from the national comorbidity survey replication (NCS-R). JAMA, 289, 3095-105. https://doi.org/10.1001/jama.289.23.3095
  20. Kiecolt-Glaser JK, Robles TF, Heffner KL, et al (2002). Psychooncology and cancer: psychoneuroimmunology and cancer. Ann Oncol, 13, 165-9.
  21. Knekt P, Raitasalo R, Helioivaara M, et al (1996). Elevated lung cancer risk among persons with depressed mood. Am J Epidemiol, 144, 1096-103. https://doi.org/10.1093/oxfordjournals.aje.a008887
  22. Kowal SJ (1955). Emotions as a cause of cancer; 18th and 19th century contributions. Psychoanal Rev, 42, 217-27.
  23. Lemogne C, Consoli SM, Melchior M, et al (2013). Depression and the risk of cancer: A 15-year follow-up study of the GAZEL cohort. Am J Epidemiol. 178, 1712-20. https://doi.org/10.1093/aje/kwt217
  24. Liang JA, Sun LM, Muo CH, et al (2011). The analysis of depression and subsequent cancer risk in Taiwan. Cancer Epidemiol Biomarkers Prev, 20, 473-5. https://doi.org/10.1158/1055-9965.EPI-10-1280
  25. Miller AH, Spencer RL, McEwen BS, et al (1993). Depression, adrenal steroids, and the immune system. Ann Med, 25, 481-7. https://doi.org/10.3109/07853899309147316
  26. Mitchell AA, Werler MM, Shapiro S (1995). A response to the commentary "Should we consider a subject's knowledge of the etiologic hypothesis in the analysis of case-control studies"? Am J Epidemiol, 141, 297-8. https://doi.org/10.1093/aje/141.4.297
  27. Nyklicek I, Louwman WJ, Van Nierop PW, et al (2003). Depression and the lower risk for breast cancer development in middle-aged women: a prospective study. Psychol Med, 33, 1111-7. https://doi.org/10.1017/S0033291703007499
  28. Oerlemans ME, Akker M, Schuurman AG, et al (2007). A metaanalysis on depression and subsequent cancer risk. Clin Pract Epidemiol Ment Health, 3, 29-40. https://doi.org/10.1186/1745-0179-3-29
  29. Penninx B, Guralnik JM, Pahor M, et al(1998). Chronically depressed mood and cancer risk in older persons. J Natl Cancer Inst, 90, 1888-93. https://doi.org/10.1093/jnci/90.24.1888
  30. Reiche EM, Morimoto HK, Nunes SM (2005). Stress and depression-induced immune dysfunction: implications for the development and progression of cancer. Int Rev Psychiatry, 17, 515-27. https://doi.org/10.1080/02646830500382102
  31. Schuurman A, Akker M, Ensinck KTJL, et al (2001). Dose depression induce susceptibilitu for somatic disease? NWOreport. Res Institute ExTra.
  32. Slattery ML, Kerber RA (1993). A comprehensive evaluation of family history and breast cancer risk. the utah population database. JAMA, 270, 1563-8. https://doi.org/10.1001/jama.1993.03510130069033
  33. Son BK, Markovitz JH, Winders S, et al (1997). Smoking, nicotine dependence, and depressive symptoms in the CARDIA Study. Effects of educational status. Am J Epidemiol, 145, 110-6. https://doi.org/10.1093/oxfordjournals.aje.a009081
  34. Soygur H, Palaoglu O, Akarsu ES, et al (2007). Interleukin-6 levels and HPA axis activation in breast cancer patients with major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry, 31, 1242-7. https://doi.org/10.1016/j.pnpbp.2007.05.001
  35. Spratt JS, Meyer JS, Spratt JA (1996). Rates of growth of human neoplasms: Part II. J Surg Oncol, 61, 68-83. https://doi.org/10.1002/1096-9098(199601)61:1<68::AID-JSO2930610102>3.0.CO;2-E
  36. Strine TW, Mokdad AH, Dube SR, et al (2008). The association of depression and anxiety with obesity and unhealthy behaviors among community-dwelling US adults. Gen Hosp Psychiatry, 30, 127-37. https://doi.org/10.1016/j.genhosppsych.2007.12.008
  37. Wallace BC, Schmid CH, Lau J, et al (2009). Meta-Analyst:software for meta-analysis of binary, continuous and diagnostic data. BMC Med Res Methodol, 9, 80. https://doi.org/10.1186/1471-2288-9-80
  38. Wells GA, Shea B, O'Connell D, et al(2006). The newcastleottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. http://www.ohri.ca/programs/clinical_epidemiology/oxford_web.ppt. Accesssed July 12, 2006
  39. World Health Organization (2008). The global burden of disease 2004 update [Online]. Available: http://www.who.int/healthinfo/globalburdendisease/GBDreport2004updatefull.pdf Accessed 16.6.2012.

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