대한의생명과학회지 (Biomedical Science Letters)

  • 제21권3호
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  • Pages.160-163
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  • 2015
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  • 1738-3226(pISSN)
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  • 2288-7415(eISSN)
대한의생명과학회 (The Korean Society for Biomedical Laboratory Sciences)
권호 표지
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Short-term Hypothermia Induces Beta-catenin-interacting Protein 1 Gene Expression in PC12 Cells

  • Kwon, Kisang (Department of Biomedical Laboratory Science, College of Health & Welfare, Kyungwoon University) ;
  • Yoo, Bo-Kyung (Department of Anatomy, College of Medicine, Chungnam National University) ;
  • Lee, Eun Ryeong (Department of Biomedical Laboratory Science, College of Health & Welfare, Kyungwoon University) ;
  • Kim, Seung-Whan (Department of Emergency Medicine, Chungnam National University Hospital) ;
  • Yu, Kweon (Korea Research Institute of Bioscience & Biotechnology) ;
  • Kwon, O-Yu (Department of Anatomy, College of Medicine, Chungnam National University)
  • 투고 : 2015.08.10
  • 심사 : 2015.09.18
  • 발행 : 2015.09.30
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초록

The effects of hypothermic treatment ($32^{\circ}C$) on recovery from ischemia are controversial because the precise mechanisms of hypothermia remain unclear. We demonstrated previously that hypothermia induces beta-catenin-interacting protein 1 (CTNNBIP1) gene expression in vitro. In this study, we evaluated the effects of various hypothermic conditions, including lithium chloride treatment, on CTNNBIP1 gene expression. The results show that short-term hypothermic treatment resulted in relatively higher CTNNBIP1 gene expression than that of a longer treatment. These findings indicate that hypothermia controls CTNNBIP1 gene expression, which may provide clues to develop treatments to recover from and diagnose ischemia.

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참고문헌

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