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Ovarian Cancer in Children and Adolescents: Treatment and Reproductive Outcomes

  • Chaopotong, Pattama (Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University) ;
  • Therasakvichya, Suwanit (Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University) ;
  • Leelapatanadit, Chairat (Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University) ;
  • Jaishuen, Atthapon (Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University) ;
  • Kuljarusnont, Sompop (Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University)
  • 발행 : 2015.06.26

초록

Objective: To review ovarian cancer cases in children and adolescents in Siriraj Hospital and assess the prognosis, recurrence of disease, and reproductive outcomes after treatment. Materials and Methods: A retrospective descriptive study was conducted in ovarian cancer patients 21 years and younger who had been treated at Siriraj Hospital between January 1990 and December 2009. Medical records were reviewed and relevant data were recorded. Results: A total of 48 cases met the criteria; their mean age was 16.4 years. Abdominal distension was the major symptom. 91.6% were germ cell tumors and the remaining cases were sex cord-stromal and epithelial tumors. More than half (25/48 cases) presented with stage I disease. The most common used chemotherapy regimen for germ cell tumors was BEP (bloemycin, etoposide, cisplatin). Most of patients had favorable outcomes; 46/48 cases had complete remission and retained their good health at the time of the review. We had only one recurrent case and one dead case. Ten of contacted patients had married and 3 of them had successful full-term pregnancies. Conclusions: Ovarian malignancy in children and adolescents is a rare disease. The authors reported 48 cases in 20 year-period of work. Most of them have favorable outcomes. Return of ovarian function and fertility are the topics of interest.

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참고문헌

  1. Aletti GD, Gallenberg MM, Cliby WA, et al (2007). Current management strategies for ovarian cancer. Mayo Clin Proc, 82, 751-70. https://doi.org/10.1016/S0025-6196(11)61196-8
  2. Berek JS, Natarajan S (2007). Ovarian and fallopian tube cancer. in 'Berek & Novak's Gynecology, 14th ed', Ed Berek JS. Lippincott Williams & Wilkins, p.1457-549.
  3. Bhurgri Y, Shaheen Y, Kayani N, et al (2011). Incidence, trends and morphology of ovarian cancer in Karachi (1995-2002). Asian Pac J Cancer Prev, 12, 1567-71.
  4. Billmire D, Vinocur C, Rescorla F, et al (2004). Outcome and staging evaluation in malignant germ cell tumors of the ovary in children and adolescents: an intergroup study. J Pediatr Surg, 39, 424-9. https://doi.org/10.1016/j.jpedsurg.2003.11.027
  5. Brookfield KF, Cheung MC, Koniaris LG, et al (2009). A population-based analysis of 1037 malignant ovarian tumors in the pediatric population. J Surg Res, 156, 45-9. https://doi.org/10.1016/j.jss.2009.03.069
  6. Deprest J, Moerman P, Corneillie P, et al (1992). Ovarian borderline mucinous tumor in a premenarchal girl: review on ovarian epithelial cancer in young girls. Gynecol Oncol, 45, 219-24. https://doi.org/10.1016/0090-8258(92)90290-Y
  7. El-Lamie IK, Shehata NA, Abou-Loz SK, et al (2000). Conservative surgical management of malignant ovarian germ cell tumors: the experience of the Gynecologic Oncology Unit at Ain Shams University. Eur J Gynaecol Oncol, 21, 605-9.
  8. Haddy TB, Mosher RB, Dinndorf PA, et al (2004). Second neoplasms in survivors of childhood and adolescent cancer are often treatable. J Adolesc Health, 34, 324-9.
  9. Haroon S, Idrees R, Zia A, et al (2014). Ovarian sex cord stromal tumours in children and young girls-a more than two decade clinicopathological experience in a developing country, Pakistan. Asian Pac J Cancer Prev, 15, 1351-5. https://doi.org/10.7314/APJCP.2014.15.3.1351
  10. Hassan E, Creatsas G, Deligeorolgou E, et al (1999). Ovarian tumors during childhood and adolescence. A clinicopathological study. Eur J Gynaecol Oncol, 20, 124-6.
  11. Johnston RJ, Wallace WH (2009). Normal ovarian function and assessment of ovarian reserve in the survivor of childhood cancer. Pediatr Blood Cancer, 53, 296-302. https://doi.org/10.1002/pbc.22012
  12. Kavanagh JJ, Pecorelli S, Benedet J, et al (2006). Cancer of the ovary. in 'staging classifications and clinical practice guidelines for gynaecological cancers', Eds. Benedet J, Pecorelli S, Ngan HY, Hacker NF. Elsevier, p.95-121.
  13. Major T, Borsos A, Lampe L, et al (1995). Ovarian malignancies in childhood and adolescence. Eur J Obstet Gynecol Reprod Biol, 63, 65-8. https://doi.org/10.1016/0301-2115(95)02231-U
  14. Nichols CR, Breeden ES, Loehrer PJ, et al (1993). Secondary leukemia associated with a conventional dose of etoposide: review of serial germ cell tumor protocols. J Natl Cancer Inst, 85, 36-40. https://doi.org/10.1093/jnci/85.1.36
  15. von Allmen D (2005). Malignant lesions of the ovary in childhood. Semin Pediatr Surg, 14, 100-5. https://doi.org/10.1053/j.sempedsurg.2005.01.005

피인용 문헌

  1. A case report of a young girl with mucinous borderline tumor of the ovary vol.59, pp.4, 2016, https://doi.org/10.5468/ogs.2016.59.4.333