Asian Pacific Journal of Cancer Prevention

  • 제16권15호
  • /
  • Pages.6225-6229
  • /
  • 2015
  • /
  • 1513-7368(pISSN)
  • /
  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
권호 표지
DOI QR코드

DOI QR Code

Effects of Two Traditional Chinese Cooking Oils, Canola and Pork, on pH and Cholic Acid Content of Faeces and Colon Tumorigenesis in Kunming Mice

  • He, Xiao-Qiong (School of Public Health, Kunming Medical University, Yunnan Province) ;
  • Duan, Jia-Li (School of Public Health, Kunming Medical University, Yunnan Province) ;
  • Zhou, Jin (School of Public Health, Kunming Medical University, Yunnan Province) ;
  • Song, Zhong-Yu (School of Public Health, Kunming Medical University, Yunnan Province) ;
  • Cichello, Simon Angelo (School of Public Health, Kunming Medical University, Yunnan Province)
  • 발행 : 2015.10.06
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Faecal pH and cholate are two important factors that can affect colon tumorigenesis, and can be modified by diet. In this study, the effects of two Chinese traditional cooking oils (pork oil and canola/rapeseed oil) on the pH and the cholic acid content in feces, in addition to colon tumorigenesis, were studied in mice. Kunming mice were randomized into various groups; negative control group (NCG), azoxymethane control group (ACG), pork oil group (POG), and canola oil Ggroup (COG). Mice in the ACG were fed a basic rodent chow; mice in POG and COG were given 10% cooking oil rodent chow with the respective oil type. All mice were given four weekly AOM (azoxymethane) i.p. injections (10mg/kg). The pH and cholic acid of the feces were examined every two weeks. Colon tumors, aberrant crypt foci and organ weights were examined 32 weeks following the final AOM injection. The results showed that canola oil significantly decreased faecal pH in female mice (P<0.05), but had no influence on feces pH in male mice (P>0.05). Pork oil significantly increased the feces pH in both male and female mice (P<0.05). No significant change was found in feces cholic acid content when mice were fed 10% pork oil or canola oil compared with the ACG. Although Kunming mice were not susceptible to AOM-induced tumorigenesis in terms of colon tumor incidence, pork oil significantly increased the ACF number in male mice. Canola oil showed no influence on ACF in either male or female mice. Our results indicate that cooking oil effects faecal pH, but does not affect the faecal cholic acid content and thus AOM-induced colon neoplastic ACF is modified by dietary fat.

키워드

참고문헌

  1. Bartoli R, Fernandez-Banares F, Navarro E, et al (2000). Effect of olive oil on early and late events of colon carcinogenesis in rats: modulation of arachidonic acid metabolism and local prostaglandin E (2) synthesis. Gut, 46, 191-9. https://doi.org/10.1136/gut.46.2.191
  2. Bartram HP, Gostner A, Scheppach W, et al (1995). Modification of fecal bile acid excretion by fish oil in healthy probands. Z Ernahrungswiss, 34, 231-5. https://doi.org/10.1007/BF01623163
  3. Cardeno A, Sanchez-Hidalgo M, Cortes-Delgado A, et al (2013). Mechanisms involved in the antiproliferative and proapoptotic effects of unsaponifiable fraction of extra virgin olive oil on HT-29 cancer cells. Nutr Cancer, 65, 908-18. https://doi.org/10.1080/01635581.2013.806674
  4. Coleman LJ, Landstrom EK, Royle PJ, et al (2002) A diet containing alpha-cellulose and fish oil reduces aberrant crypt foci formation and modulates other possible markers for colon cancer risk in azoxymethane-treated rats. J Nutr, 132, 2312-8.
  5. Davis PA, Iwahashi CK (2001). Whole almonds and almond fractions reduce aberrant crypt foci in a rat model of colon carcinogenesis. Cancer Lett, 165, 27-33. https://doi.org/10.1016/S0304-3835(01)00425-6
  6. Franca Fda S, Bodack C, Costa A, et al (2014). The effect of dietary oils on the development of aberrant crypt foci, bifidobacteria and fecal pH. In Vivo, 28, 197-203.
  7. Fujise T, Iwakiri R, Kakimoto T, et al (2007). Long-term feeding of various fat diets modulates azoxymethane-induced colon carcinogenesis through Wnt/beta-catenin signaling in rats. Am J Physiol Gastrointest Liver Physiol, 292, G1150-6.
  8. Galeone C, Talamini R, Levi F, et al (2007). Franceschi S, La Vecchia C. Fried foods, olive oil and colorectal cancer. Ann Oncol, 18, 36-9.
  9. Geter DR, George MH, Moore TM, et al (2004). The effects of a high animal fat diet on the induction of aberrant crypt foci in the colons of male F344/N rats exposed to trihalomethanes in the drinking water. Toxicol Lett, 147, 245-52. https://doi.org/10.1016/j.toxlet.2003.11.006
  10. He XQ, Cichello SA, Duan JL, et al (2014). Canola oil influence on azoxymethane-induced colon carcinogenesis, hypertriglyceridemia and hyperglycemia in Kunming mice. Asian Pac J Cancer Prev, 15, 2477-83. https://doi.org/10.7314/APJCP.2014.15.6.2477
  11. Hakim L, Alias E, Makpol S, et. al (2014). Gelam honey and ginger potentiate the anti cancer effect of 5-FU against HCT 116 colorectal cancer cells. Asian Pac J Cancer Prev, 15, 4651-7. https://doi.org/10.7314/APJCP.2014.15.11.4651
  12. Kaneko R, Nakazaki N, Tagawa T, et al (2014). A new index of abdominal obesity which effectively predicts risk of colon tumor development in female Japanese. Asian Pac J Cancer Prev, 15, 1005-10. https://doi.org/10.7314/APJCP.2014.15.2.1005
  13. Kim ER, Chang DK. (2014). Colorectal cancer in inflammatory bowel disease: the risk, pathogenesis, prevention and diagnosis. World J Gastroenterol, 20, 9872-81. https://doi.org/10.3748/wjg.v20.i29.9872
  14. Kohno H, Suzuki R, Yasui Y, et al (2004). Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats. Cancer Sci, 95, 481-6. https://doi.org/10.1111/j.1349-7006.2004.tb03236.x
  15. Kohno H, Yasui Y, Suzuki R, et al (2004). Dietary seed oil rich in conjugated linolenic acid from bitter melon inhibits azoxymethane-induced rat colon carcinogenesis through elevation of colonic PPARgamma expression and alteration of lipid composition. Int J Cancer, 110, 896-901. https://doi.org/10.1002/ijc.20179
  16. Liang Z, Guo YT, Yi YJ, et al (2014). Ganoderma lucidum polysaccharides target a Fas/caspase dependent pathway to induce apoptosis in human colon cancer cells. Asian Pac J Cancer Prev, 15, 3981-6. https://doi.org/10.7314/APJCP.2014.15.9.3981
  17. McLellan E, Bird RP. (1991). Effect of disulfiram on 1, 2-dimethylhydrazine- and azoxymethane-induced aberrant crypt foci. Carcinogenesis, 12, 969-72. https://doi.org/10.1093/carcin/12.6.969
  18. Moreira AP, Sabarense CM, Dias CM, et al (2009). Fish oil ingestion reduces the number of aberrant crypt foci and adenoma in 1, 2-dimethylhydrazine-induced colon cancer in rats. Braz J Med Biol Res, 42, 1167-72. https://doi.org/10.1590/S0100-879X2009001200008
  19. Pandurangan AK, Esa NM. (2014). Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review. Asian Pac J Cancer Prev, 15, 5501-8. https://doi.org/10.7314/APJCP.2014.15.14.5501
  20. Parnaud G, Peiffer G, Tache S, et al. (1998). Effect of meat (beef, chicken, and bacon) on rat colon carcinogenesis. Nutr Cancer, 32, 165-73. https://doi.org/10.1080/01635589809514736
  21. Pierre F, Santarelli R, Tache S, et al (2008). Beef meat promotion of dimethylhydrazine-induced colorectal carcinogenesis biomarkers is suppressed by dietary calcium. Br J Nutr, 99, 1000-6.
  22. Quassinti L, Maggi F, Barboni L, et al (2014). Wild celery (Smyrnium olusatrum L.) oil and isofuranodiene induce apoptosis in human colon carcinoma cells. Fitoterapia, 97, 133-41. https://doi.org/10.1016/j.fitote.2014.06.004
  23. Rao CV, Hirose Y, Indranie C, et al (2001). Modulation of experimental colon tumorigenesis by types and amounts of dietary fatty acids. Cancer Res, 61, 1927-33.
  24. Rogers KJ, Pegg AE (1977). Formation of O6-methylguanine by alkylation of rat liver, colon, and kidney DNA following administration of 1, 2-dimethylhydrazine. Cancer Res, 37, 4082-7.
  25. Rosa DD, Lourenco FC, da Fonseca AC, et al (2012). Fish oil improves the lipid profile and reduces inflammatory cytokines in Wistar rats with precancerous colon lesions. Nutr Cancer, 64, 569-79. https://doi.org/10.1080/01635581.2012.665563
  26. Salim EI, Abou-Shafey AE, Masoud AA, et al (2011). Cancer chemopreventive potential of the Egyptian flaxseed oil in a rat colon carcinogenesis bioassay-implications for its mechanism of action. Asian Pac J Cancer Prev, 12, 2385-92.
  27. Slattery ML, Lundgreen A, Wolff RK (2013). Dietary influence on MAPK-signaling pathways and risk of colon and rectal cancer. Nutr Cancer, 65, 729-38. https://doi.org/10.1080/01635581.2013.795599
  28. Somchit M, Changtam C, Kimseng R, et al (2014). Demethoxycurcumin from curcuma longa rhizome suppresses iNOS induction in an in vitro inflamed human intestinal mucosa model. Asian Pac J Cancer Prev, 15, 1807-10. https://doi.org/10.7314/APJCP.2014.15.4.1807
  29. Sung JJ, Lau JY, Goh KL, et al (2005). Asia pacific working group on colorectal cancer. Increasing incidence of colorectal cancer in Asia: implications for screening. Lancet Oncol, 6, 871-6. https://doi.org/10.1016/S1470-2045(05)70422-8
  30. van Beelen VA, Spenkelink B, Mooibroek H, et al (2009). An n-3 PUFA-rich microalgal oil diet protects to a similar extent as a fish oil-rich diet against AOM-induced colonic aberrant crypt foci in F344 rats. Food Chem Toxicol, 47, 316-20. https://doi.org/10.1016/j.fct.2008.11.014
  31. Williams D, Verghese M, Walker LT, et al (2007). Flax seed oil and flax seed meal reduce the formation of aberrant crypt foci (ACF) in azoxymethane-induced colon cancer in Fisher 344 male rats via increased Glutathione-S-transferase activities and presumed anti-oxidant activity. Food Chem Toxicol, 45, 153-9. https://doi.org/10.1016/j.fct.2006.08.014
  32. Wu B, Iwakiri R, Ootani A, et al (2004). Dietary corn oil promotes colon cancer by inhibiting mitochondria-dependent apoptosis in azoxymethane-treated rats. Exp Biol Med Maywood, 229, 1017-25.