Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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p16 Expression as a Surrogate Marker for HPV Infection in Esophageal Squamous Cell Carcinoma can Predict Response to Neo-Adjuvant Chemotherapy

  • Kumar, Rajeev (Cachar Cancer Hospital & Research Centre, Assam University) ;
  • Ghosh, Sankar Kumar (Department of Biotechnology, Assam University) ;
  • Verma, Akalesh Kumar (Cachar Cancer Hospital & Research Centre, Assam University) ;
  • Talukdar, Anuradha (Cachar Cancer Hospital & Research Centre, Assam University) ;
  • Deka, Monoj Kumar (Silchar Medical College & Hospital) ;
  • Wagh, Mira (Cachar Cancer Hospital & Research Centre, Assam University) ;
  • Bahar, H.M. Iqbal (Cachar Cancer Hospital & Research Centre, Assam University) ;
  • Tapkire, Ritesh (Cachar Cancer Hospital & Research Centre, Assam University) ;
  • Chakraborty, Kali Pankaj (Cachar Cancer Hospital & Research Centre, Assam University) ;
  • Kannan, R. Ravi (Cachar Cancer Hospital & Research Centre, Assam University)
  • Published : 2015.11.04
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Abstract

Background: Esophageal squamous cell carcinoma (ESCC) is a common cancer in the north east of India. The present study concerned the prevalence of human papilloma virus (HPV) in the ESCC in north eastern India and its impact on response to chemotherapy. Materials and Methods: p16 expression, a surrogate marker for HPV infection was assessed in 101 pre-treatment biopsies of locally advanced ESCC, reported from a comprehensive cancer centre in north east India, using immunohistochemistry. All patients received neo-adjuvant chemotherapy. Response was assessed clinically and histopathologically with attention to p16 expression. Results: p16 was expressed in 22% of ESCC (22 out of 101) and was more prevalent in patients who were more than 45 years of age (P=0.048). p16 positive tumors appeared more commonly in the upper 2/3 of the thoracic esophagus (18 in 22). Nine of the 22 (41%) p16 positive tumors achieved pathologic complete response following neo-adjuvant chemotherapy (P=0.008). There was a trend towards reduced mortality in this group (P=0.048). Some 9 of the 20 (45%) patients who achieved pathologic complete response were p16 positive. Conclusions: Expression of p16 in ESCC correlates with higher rate of pathologic complete remission in patients undergoing neo adjuvant chemotherapy and could be a predictive marker for response assessment.

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References

  1. Ali I, Wani WA, Saleem, K (2011). Cancer scenario in India with future perspectives. Cancer Ther, 8, 56-70.
  2. Ang KK, Harris J, Wheeler R, et al (2010). Human papillomavirus and survival of patients with oropharyngeal cancer. N England J Med, 363, 24-35. https://doi.org/10.1056/NEJMoa0912217
  3. Cao F, Zhang W, Zhang F, et al (2014). Prognostic significance of high-risk human papillomavirus and p16INK4A in patients with esophageal squamous cell carcinoma. Int J Clin Exp Med, 7, 3430-8.
  4. Cao F, Han H, Zhang F, et al (2014). HPV infection in esophageal squamous cell carcinoma and its relationship to the prognosis of patients in northern China. Scientific World J, 2014, 1-9.
  5. Chung CS, Lee YC, Wang CP, et al (2010). Secondary prevention of esophageal squamous cell carcinoma in areas where smoking, alcohol, and betel quid chewing are prevalent. J Formos Med Assoc, 109, 408-21. https://doi.org/10.1016/S0929-6646(10)60072-1
  6. de Villiers EM, Lavergne D, Chang F, et al (1999). An interlaboratory study to determine the presence of human papillomavirus DNA in esophageal carcinoma from China. Int J Cancer, 81, 225-8. https://doi.org/10.1002/(SICI)1097-0215(19990412)81:2<225::AID-IJC10>3.0.CO;2-0
  7. El-Naggar AK, Westra WH (2012). p16 expression as a surrogate marker for HPV-related oropharyngeal carcinoma: a guide for interpretative relevance and consistency. Head Neck, 34, 459-61. https://doi.org/10.1002/hed.21974
  8. Fischer CA, Kampmann M, Zlobec I, et al (2010). p16 expression in oropharyngeal cancer: its impact on staging and prognosis compared with the conventional clinical staging parameters. Ann Oncol, 21, 1961-6. https://doi.org/10.1093/annonc/mdq210
  9. Hardefeldt HA, Cox MR, Eslick GD (2014). Association between human papillomavirus (HPV) and oesophageal squamous cell carcinoma: a meta-analysis. Epidemiol Infection, 142, 1119-37. https://doi.org/10.1017/S0950268814000016
  10. International Agency for Research on Cancer (2014). Available: http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx.
  11. Kalof AN, Cooper K (2006). p16INK4a immunoexpression: surrogate marker of high-risk HPV and high-grade cervical intraepithelial neoplasia. Adv Anat Pathol, 13, 190-4. https://doi.org/10.1097/00125480-200607000-00006
  12. Katiyar S, Hedau S, Jain N, Kar, et al (2005). p53 gene mutation and human papillomavirus (HPV) infection in esophageal carcinoma from three different endemic geographic regions of India. Cancer Lett, 218, 69-79. https://doi.org/10.1016/j.canlet.2004.09.003
  13. Lagergren J, Lagergren P (2010). Oesophageal cancer. BMJ, 21, 341-6280.
  14. Liyanage SS, Rahman B, Ridda I, et al (2013). The aetiological role of human papillomavirus in oesophageal squamous cell carcinoma: a meta-analysis. Plos One, 8, 1-12.
  15. Ma YY, Ye F, Chen XD, et al (2010). Evaluation of P16($INK4{\alpha}$) expression in Thinprep cervical specimens for the predication of high-grade cervical intraepithelial neoplasia. Zhonghua Yi Xue Za Zhi, 90, 3040-4.
  16. Mohiuddin MK, Chava S, Upendrum P, et al (2013). Role of human papilloma virus infection and altered methylation of specific genes in esophageal cancer. Asian Pac J Cancer Prev, 14, 4187-93. https://doi.org/10.7314/APJCP.2013.14.7.4187
  17. Murthy NS, Chaudhry K, Rath GK (2008). Burden of cancer and projections for 2016, Indian scenario: gaps in the availability of radiotherapy treatment facilities. Asian Pac J Cancer Prev, 9, 671-77.
  18. Murthy NS, Nandakumar BS, Shivaraj NS, et al (2010). Cancer registration: its relevance for health care planning in india. Indian J Prev Soc Med, 41, 75-87.
  19. National Cancer Registry Program (2013). Available at http://www.ncrpindia.org/Annual_Reports.aspx
  20. Petrick JL, Wyss AB, Butler AM, et al (2014). Prevalence of human papillomavirus among oesophageal squamous cell carcinoma cases: systematic review and meta-analysis. BR J Cancer, 110, 2369-77. https://doi.org/10.1038/bjc.2014.96
  21. Pramesh CS, Karimundackal G, Jiwnani S (2015). Squamous cell carcinoma of the oesophagus. in 'esophageal squamous cell carcinoma', Springer Japan, 279-303.
  22. Sanne Hoxbroe Michaelsen, Christian Gronhoj Larsen, Christian von Buchwald (2014). Human papillomavirus shows highly variable prevalence in esophageal squamous cell carcinoma and no significant correlation to p16ink4a overexpression a systematic review. J Thorac Oncol, 9, 865-71. https://doi.org/10.1097/JTO.0000000000000166
  23. Shukla S, Bharti AC, Mahata S, et al (2009). Infection of human papillomaviruses in cancers of different human organ sites. Indian J Med Res, 130, 222-33.
  24. Souza GD, Kreimer AR, Viscidi R, et al (2007). Case-control study of human papillomavirus and oropharyngeal cancer. N England J Med, 356, 1944-56. https://doi.org/10.1056/NEJMoa065497
  25. Syrjanen K, Pyrhonen S, Aukee S, Koskela E (1982). Squamous cell papilloma of the esophagus: a tumour probably caused by human papilloma virus (HPV). Diagn Histopathol, 5, 291-6.
  26. Syrjanen KJ (2002). HPV infections and oesophageal cancer. J Clin Pathol, 55, 721-8. https://doi.org/10.1136/jcp.55.10.721
  27. Takiar R, Nadayil D, Nandakumar A (2010). Projections of number of cancer cases in India (2010-2020) by cancer groups. Asian Pac J Cancer Prev, 11, 1045-49.
  28. Vaiphei K, Kochhar R, Bhardawaj S, et al (2013). High prevalence of human papillomavirus in esophageal squamous cell carcinoma: a study in paired samples. Dis Esophagus, 26, 282-7. https://doi.org/10.1111/j.1442-2050.2012.01365.x
  29. Walboomers JM, Jacobs MV, Manos MM, et al (1999). Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol, 189, 12-9. https://doi.org/10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F
  30. Zhang SK, Guo LW, Chen Q, et al (2014). Prevalence of human papillomavirus 16 in esophageal cancer among the Chinese population: a systematic review and meta-analysis. Asian Pac J Cancer Prev, 15, 10143-49.
  31. Zur Hausen H (2009). Papillomaviruses in the causation of human cancers - a brief historical account. Virol, 384, 260-5. https://doi.org/10.1016/j.virol.2008.11.046

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